标题
Principles of antibody-mediated TNF receptor activation
作者
关键词
-
出版物
CELL DEATH AND DIFFERENTIATION
Volume 22, Issue 11, Pages 1727-1741
出版商
Springer Nature
发表日期
2015-08-21
DOI
10.1038/cdd.2015.109
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- The tetravalent anti-DR5 antibody without cross-linking direct induces apoptosis of cancer cells
- (2015) Fengtao Liu et al. BIOMEDICINE & PHARMACOTHERAPY
- Conformation of the Human Immunoglobulin G2 Hinge Imparts Superagonistic Properties to Immunostimulatory Anticancer Antibodies
- (2015) Ann L. White et al. CANCER CELL
- Unexpected hepatotoxicity in a phase I study of TAS266, a novel tetravalent agonistic Nanobody® targeting the DR5 receptor
- (2015) Kyriakos P. Papadopoulos et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Structure of FcγRI in complex with Fc reveals the importance of glycan recognition for high-affinity IgG binding
- (2015) Jinghua Lu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Principles and mechanisms of CD95 activation
- (2014) Harald Wajant BIOLOGICAL CHEMISTRY
- Apo2L/TRAIL and the Death Receptor 5 Agonist Antibody AMG 655 Cooperate to Promote Receptor Clustering and Antitumor Activity
- (2014) Jonathan D. Graves et al. CANCER CELL
- Getting TRAIL back on track for cancer therapy
- (2014) J Lemke et al. CELL DEATH AND DIFFERENTIATION
- OX40 engagement depletes intratumoral Tregs via activating FcγRs, leading to antitumor efficacy
- (2014) Yannick Bulliard et al. IMMUNOLOGY AND CELL BIOLOGY
- Dominant Negative Effects of Tumor Necrosis Factor (TNF)-related Apoptosis-inducing Ligand (TRAIL) Receptor 4 on TRAIL Receptor 1 Signaling by Formation of Heteromeric Complexes
- (2014) Simon Neumann et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Galectin-9 controls the therapeutic activity of 4-1BB–targeting antibodies
- (2014) Shravan Madireddi et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Fcγ Receptor Dependency of Agonistic CD40 Antibody in Lymphoma Therapy Can Be Overcome through Antibody Multimerization
- (2014) Ann L. White et al. JOURNAL OF IMMUNOLOGY
- Multivalent nanobodies targeting death receptor 5 elicit superior tumor cell killing through efficient caspase induction
- (2014) Heather A Huet et al. mAbs
- Type I and type II Fc receptors regulate innate and adaptive immunity
- (2014) Andrew Pincetic et al. NATURE IMMUNOLOGY
- TRAIL-R2-specific antibodies and recombinant TRAIL can synergise to kill cancer cells
- (2014) M H Tuthill et al. ONCOGENE
- HIV-1 Adenoviral Vector Vaccines Expressing Multi-Trimeric BAFF and 4-1BBL Enhance T Cell Mediated Anti-Viral Immunity
- (2014) Saravana Kanagavelu et al. PLoS One
- Mechanistic Basis for Functional Promiscuity in the TNF and TNF Receptor Superfamilies: Structure of the LIGHT:DcR3 Assembly
- (2014) Weifeng Liu et al. STRUCTURE
- Nuclear Factor κB is Required for Tumor Growth Inhibition Mediated by Enavatuzumab (PDL192), a Humanized Monoclonal Antibody to TweakR
- (2014) James W. Purcell et al. Frontiers in Immunology
- TNF Receptor-Associated Factor 1 is a Major Target of Soluble TWEAK
- (2014) José Antonio Carmona Arana et al. Frontiers in Immunology
- Structure of the extracellular domains of human andXenopusFn14: implications in the evolution of TWEAK and Fn14 interactions
- (2013) Maria Pellegrini et al. FEBS Journal
- Safety, pharmacokinetics, and pharmacodynamics of the DR5 antibody LBY135 alone and in combination with capecitabine in patients with advanced solid tumors
- (2013) Sunil Sharma et al. INVESTIGATIONAL NEW DRUGS
- Fibroblast Growth Factor Inducible (Fn14)-specific Antibodies Concomitantly Display Signaling Pathway-specific Agonistic and Antagonistic Activity
- (2013) Steffen Salzmann et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies
- (2013) Yannick Bulliard et al. JOURNAL OF EXPERIMENTAL MEDICINE
- A novel llama antibody targeting Fn14 exhibits anti-metastatic activity in vivo
- (2013) Johannes Trebing et al. mAbs
- An engineered Fc variant of an IgG eliminates all immune effector functions via structural perturbations
- (2013) Omid Vafa et al. METHODS
- Tetravalent Antibody-scTRAIL Fusion Proteins with Improved Properties
- (2013) O. Seifert et al. MOLECULAR CANCER THERAPEUTICS
- APG350 Induces Superior Clustering of TRAIL Receptors and Shows Therapeutic Antitumor Efficacy Independent of Cross-Linking via Fc Receptors
- (2013) C. Gieffers et al. MOLECULAR CANCER THERAPEUTICS
- Dimerization of LT R by LT 1 2 is necessary and sufficient for signal transduction
- (2013) J. Sudhamsu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Antitumor activities of agonistic anti-TNFR antibodies require differential Fc RIIB coengagement in vivo
- (2013) F. Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CD95 in cancer: tool or target?
- (2013) Ana Martin-Villalba et al. TRENDS IN MOLECULAR MEDICINE
- S-SAD phasing study of death receptor 6 and its solution conformation revealed by SAXS
- (2012) Heng Ru et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Properties of mouse and human IgG receptors and their contribution to disease models
- (2012) P. Bruhns BLOOD
- Signaling Active CD95 Receptor Molecules Trigger Co-translocation of Inactive CD95 Molecules into Lipid Rafts
- (2012) Isabell Lang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Crystal Structure of Human RANKL Complexed with Its Decoy Receptor Osteoprotegerin
- (2012) X. Luan et al. JOURNAL OF IMMUNOLOGY
- A Death Effector Domain Chain DISC Model Reveals a Crucial Role for Caspase-8 Chain Assembly in Mediating Apoptotic Cell Death
- (2012) Laura S. Dickens et al. MOLECULAR CELL
- Stoichiometry of the CD95 Death-Inducing Signaling Complex: Experimental and Modeling Evidence for a Death Effector Domain Chain Model
- (2012) Kolja Schleich et al. MOLECULAR CELL
- Apoptotic and antitumor activity of death receptor antibodies require inhibitory Fc receptor engagement
- (2012) F. Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cellular Inhibitors of Apoptosis Are Global Regulators of NF- B and MAPK Activation by Members of the TNF Family of Receptors
- (2012) E. Varfolomeev et al. Science Signaling
- RANKL Employs Distinct Binding Modes to Engage RANK and the Osteoprotegerin Decoy Receptor
- (2012) Christopher A. Nelson et al. STRUCTURE
- An Fcγ Receptor-Dependent Mechanism Drives Antibody-Mediated Target-Receptor Signaling in Cancer Cells
- (2011) Nicholas S. Wilson et al. CANCER CELL
- Engineering death receptor ligands for cancer therapy
- (2011) Harald Wajant et al. CANCER LETTERS
- Antibody-based fusion proteins to target death receptors in cancer
- (2011) Marco de Bruyn et al. CANCER LETTERS
- Structural basis for improved efficacy of therapeutic antibodies on defucosylation of their Fc glycans
- (2011) Tsunehiro Mizushima et al. GENES TO CELLS
- Studies of Binding of Tumor Necrosis Factor (TNF)-like Weak Inducer of Apoptosis (TWEAK) to Fibroblast Growth Factor Inducible 14 (Fn14)
- (2011) Andrea Fick et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Crystallographic and Mutational Analysis of the CD40-CD154 Complex and Its Implications for Receptor Activation
- (2011) Hyun-Jung An et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Smac Mimetics Activate the E3 Ligase Activity of cIAP1 Protein by Promoting RING Domain Dimerization
- (2011) Rebecca Feltham et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structural Basis for Fc RIIa Recognition of Human IgG and Formation of Inflammatory Signaling Complexes
- (2011) P. A. Ramsland et al. JOURNAL OF IMMUNOLOGY
- Interaction with Fc RIIB Is Critical for the Agonistic Activity of Anti-CD40 Monoclonal Antibody
- (2011) A. L. White et al. JOURNAL OF IMMUNOLOGY
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- (2011) Miriam Kuester et al. JOURNAL OF MOLECULAR BIOLOGY
- Development of an Fn14 agonistic antibody as an anti-tumor agent
- (2011) Jennifer S. Michaelson et al. mAbs
- Expression and Purification of a Natural N-Terminal Pre-ligand Assembly Domain of Tumor Necrosis Factor Receptor 1 (TNFR1 PLAD) and Preliminary Activity Determination
- (2011) Jin Cao et al. PROTEIN JOURNAL
- Antagonists Induce a Conformational Change in cIAP1 That Promotes Autoubiquitination
- (2011) E. C. Dueber et al. SCIENCE
- Inhibitory Fc Receptor Engagement Drives Adjuvant and Anti-Tumor Activities of Agonistic CD40 Antibodies
- (2011) F. Li et al. SCIENCE
- Decoy Strategies: The Structure of TL1A:DcR3 Complex
- (2011) Chenyang Zhan et al. STRUCTURE
- Soluble multi-trimeric TNF superfamily ligand adjuvants enhance immune responses to a HIV-1 Gag DNA vaccine
- (2011) Saravana K. Kanagavelu et al. VACCINE
- LBY135, a novel anti-DR5 agonistic antibody induces tumor cell-specific cytotoxic activity in human colon tumor cell lines and xenografts
- (2010) Jing Li et al. DRUG DEVELOPMENT RESEARCH
- Soluble and Transmembrane TNF-Like Weak Inducer of Apoptosis Differentially Activate the Classical and Noncanonical NF- B Pathway
- (2010) C. Roos et al. JOURNAL OF IMMUNOLOGY
- Structural and Functional Insights of RANKL-RANK Interaction and Signaling
- (2010) C. Liu et al. JOURNAL OF IMMUNOLOGY
- Asymmetric Recruitment of cIAPs by TRAF2
- (2010) Peter D. Mace et al. JOURNAL OF MOLECULAR BIOLOGY
- Dimers and multimers of monoclonal IgG1 exhibit higher in vitro binding affinities to Fcγ receptors
- (2010) Yin Luo et al. mAbs
- Crystal Structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 Complexes: Affinity, Specificity, and Regulation
- (2010) Chao Zheng et al. MOLECULAR CELL
- Structural and functional insights into 5′-ppp RNA pattern recognition by the innate immune receptor RIG-I
- (2010) Yanli Wang et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Structure-based development of a receptor activator of nuclear factor- B ligand (RANKL) inhibitor peptide and molecular basis for osteopetrosis
- (2010) H. M. Ta et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Solution structure of the cysteine-rich domain in Fn14, a member of the tumor necrosis factor receptor superfamily
- (2010) Fahu He et al. PROTEIN SCIENCE
- Solution of the Structure of the TNF-TNFR2 Complex
- (2010) Y. Mukai et al. Science Signaling
- Solution NMR Investigation of the CD95/FADD Homotypic Death Domain Complex Suggests Lack of Engagement of the CD95 C Terminus
- (2010) Diego Esposito et al. STRUCTURE
- 1.8 Å structure of murine GITR ligand dimer expressed inDrosophila melanogasterS2 cells
- (2009) Kausik Chattopadhyay et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Biochemical and Structural Characterization of the Human TL1A Ectodomain,
- (2009) Chenyang Zhan et al. BIOCHEMISTRY
- TNF-like weak inducer of apoptosis inhibits proinflammatory TNF receptor-1 signaling
- (2009) A Wicovsky et al. CELL DEATH AND DIFFERENTIATION
- Oligomerized tumor necrosis factor-related apoptosis inducing ligand strongly induces cell death in myeloma cells, but also activates proinflammatory signaling pathways
- (2009) Daniela Berg et al. FEBS Journal
- The Structure of the Trimer of Human 4-1BB Ligand Is Unique among Members of the Tumor Necrosis Factor Superfamily
- (2009) Eun-Young Won et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Membrane Tumor Necrosis Factor (TNF) Induces p100 Processing via TNF Receptor-2 (TNFR2)
- (2009) Hilka Rauert et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Biological Activity of Ectodysplasin A Is Conditioned by Its Collagen and Heparan Sulfate Proteoglycan-binding Domains
- (2009) Lee Kim Swee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Trimer Stabilization, Oligomerization, and Antibody-Mediated Cell Surface Immobilization Improve the Activity of Soluble Trimers of CD27L, CD40L, 41BBL, and Glucocorticoid-Induced TNF Receptor Ligand
- (2009) A. Wyzgol et al. JOURNAL OF IMMUNOLOGY
- Molecular and Structural Insight into proNGF Engagement of p75NTR and Sortilin
- (2009) Dan Feng et al. JOURNAL OF MOLECULAR BIOLOGY
- The Fas–FADD death domain complex structure unravels signalling by receptor clustering
- (2009) Fiona L. Scott et al. NATURE
- Membrane-bound Fas ligand only is essential for Fas-induced apoptosis
- (2009) Lorraine A. O’ Reilly et al. NATURE
- A novel humanized anti-human death receptor 5 antibody CS-1008 induces apoptosis in tumor cells without toxicity in hepatocytes
- (2008) A. Yada et al. ANNALS OF ONCOLOGY
- Specificity and affinity of human Fc receptors and their polymorphic variants for human IgG subclasses
- (2008) P. Bruhns et al. BLOOD
- Activity of soluble OX40 ligand is enhanced by oligomerization and cell surface immobilization
- (2008) Nicole Müller et al. FEBS Journal
- TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1–TRAF2 complex to sensitize tumor cells to TNFα
- (2008) James E. Vince et al. JOURNAL OF CELL BIOLOGY
- Death receptor 5 mediated-apoptosis contributes to cholestatic liver disease
- (2008) K. Takeda et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural basis for ligand-mediated mouse GITR activation
- (2008) Z. Zhou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Evolution of GITRL immune function: Murine GITRL exhibits unique structural and biochemical properties within the TNF superfamily
- (2008) K. Chattopadhyay et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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