Article
Biochemistry & Molecular Biology
Bang-Xu Nie, Gang Zhao, Xiao-Feng Yuan, Lin-Xin Yu, Jin Zhang, Yong Yuan, Yao Liu, Jun Hu, En Song, Yu-Cheng Zhou, Jun Shu
Summary: The study in rat models found that downregulation of CDK1 inhibited the activation of anterior horn astrocytes and microglia, promoted the repair of motor neurons, and suppressed neuronal apoptosis and autophagy, leading to the recovery of motor function after spinal cord injury.
JOURNAL OF CHEMICAL NEUROANATOMY
(2022)
Article
Cell Biology
Yilin Pang, Xinjie Liu, Xu Wang, Xuelian Shi, Lei Ma, Yan Zhang, Tiangang Zhou, Chenxi Zhao, Xu Zhang, Baoyou Fan, Jian Hao, Wenxiang Li, Xiaoqing Zhao, Rong Zhang, Songlin Zhou, Xiaohong Kong, Shiqing Feng, Xue Yao
Summary: Edaravone, an FDA-approved drug, has a neuroprotective effect on spinal cord injury and other central nervous system diseases. It exerts this effect by inhibiting ferroptosis and reducing neuroinflammation. The mechanism may be applicable to other neurological diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mohammad-Masoud Zavvarian, James Hong, Mohamad Khazaei, Jonathon Chon Teng Chio, Jian Wang, Anna Badner, Michael G. Fehlings
Summary: This study demonstrated that intraperitoneal injection of midostaurin in injured rats led to alterations in local inflammasome and gene expression, resulting in enhanced recovery and improved coordination between forelimbs and hindlimbs after injury. Histological analysis also indicated improved tissue preservation and functionality in treated animals during the chronic phase of injury. Overall, systemic administration of midostaurin proved to be an effective strategy for mitigating cervical secondary SCI damage.
Article
Biochemistry & Molecular Biology
Alessia Filippone, Deborah Mannino, Laura Cucinotta, Irene Paterniti, Emanuela Esposito, Michela Campolo
Summary: This study aimed to investigate the role of PF06447475 as a pharmacological LRRK2 antagonist in counteracting the pathological consequences of spinal cord trauma. By using an in vivo model of SCI induced by extradural compression, it was found that treatment with PF-475 significantly reduced spinal cord tissue injury, glycogen accumulation, and demyelination of neurons associated with trauma. Additionally, LRRK2 antagonist treatment decreased oxidative stress and cytokine expression levels, suggesting that targeting LRRK2 activity could have direct effects on intervening in neuroinflammatory disorders.
Article
Clinical Neurology
Zhihua Wang, Zhiwu Wu, Zhiping Xie, Wu Zhou, Meihua Li
Summary: This study found that Met can have a neuroprotective effect on the repair of traumatic spinal cord injury by inhibiting ferroptosis, improving long-term outcomes and reducing locomotor deficits.
WORLD NEUROSURGERY
(2022)
Article
Medicine, Research & Experimental
Bo Xu, Jiaqi Fang, Jianguang Wang, Xuehan Jin, Shengfu Liu, Kaihang Song, Ping Wang, Junjian Liu, Shuhao Liu
Summary: This study investigated the protective effect of edaravone on blood spinal cord barrier (BSCB) disruption after spinal cord injury (SCI). The results showed that edaravone treatment promoted functional recovery, improved vascular damage, and up-regulated BSCB-associated proteins in rats with SCI. In vitro experiments also demonstrated that edaravone improved cell viability, restored intercellular junctions, and promoted angiogenic activities. The underlying mechanism may involve the improvement of autophagy and the phosphorylation of RIP1/RIP3/MLKL. Overall, edaravone can be a potential treatment option for SCI.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Zhiyang Huang, Jiahong Gong, Wen Lin, Zhiyi Feng, Yirou Ma, Yurong Tu, Xiong Cai, Jianhua Liu, Chang Lv, Xinru Lv, Qiuji Wu, Wenjie Lu, Juan Zhao, Yibo Ying, Shengcun Li, Wenfei Ni, Haili Chen
Summary: CAT can inhibit neuronal apoptosis in SCI by reducing endoplasmic reticulum stress and activating the Caspase3/Bax/Bcl-2 pathway, and it has the potential to be a therapeutic drug for SCI.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
May-Jywan Tsai, Li-Yu Fay, Dann-Ying Liou, Yi Chen, Ya-Tzu Chen, Meng-Jen Lee, Tsung-Hsi Tu, Wen-Cheng Huang, Henrich Cheng
Summary: Traumatic spinal cord injury (SCI) triggers a series of cellular and molecular events, leading to both primary and secondary injury cascades. The secondary cascade provides an opportunity for therapeutic intervention, and in this study, the effects of Growth differentiation factor 11 (GDF11) on spinal cord injury were investigated. The results showed that GDF11 increased the survival of neuronal and oligodendroglial cells and decreased microglial cells. In addition, GDF11 protected neurons from ischemic damage and improved hindlimb functional restoration in SCI rat models. These findings suggest that GDF11 infusion could be a beneficial therapeutic approach for SCI in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Youngkyung Kim, Kyu-won Park, Eunji Lee, Young Wook Yoon
Summary: Traumatic spinal cord injury causes secondary damage due to oxygen and energy deprivation. PPAR gamma, known for its role in cell survival mechanisms, has the potential for neuroprotection. However, the role of endogenous spinal PPAR gamma in SCI is not well established.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Engineering, Biomedical
Jile Xie, Jiaying Li, Jinjin Ma, Meimei Li, Xingran Wang, Xinya Fu, Yanxia Ma, Huilin Yang, Bin Li, Saijilafu
Summary: Due to the limited regenerative ability of the central nervous system, effective treatments for spinal cord injury have been lacking. The study found that a MgO/PLCL scaffold loaded with PUR and RA can reduce glial scar formation and promote neuronal differentiation of endogenous NSCs, leading to partial recovery of locomotor function in SCI mice.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Senyu Yao, Mao Pang, Yanheng Wang, Xiaokang Wang, Yaobang Lin, Yanyan Lv, Ziqi Xie, Jianfeng Hou, Cong Du, Yuan Qiu, Yuanjun Guan, Bin Liu, Jiancheng Wang, Andy Peng Xiang, Limin Rong
Summary: This study demonstrates that mitochondrial quality control plays a crucial role in regulating neuronal ferroptosis and mesenchymal stem cells can attenuate ferroptosis through mitochondrial transfer and fusion. The findings provide insights into the molecular mechanism underlying neuronal ferroptosis and suggest a potential clinical translation strategy using stem cell-mediated mitochondrial therapy.
Article
Immunology
Chenfeng Wang, Hongdao Ma, Bangke Zhang, Tong Hua, Haibin Wang, Liang Wang, Lin Han, Qisheng Li, Weiqing Wu, Yulin Sun, Haisong Yang, Xuhua Lu
Summary: This study screened out novel targets for spinal cord injury (SCI) using bioinformatics methods and verified their mechanism and therapeutic effects in a rat model. The targets CASP4, IGSF6, and IL1R1 were identified as potential diagnostic and therapeutic targets for SCI and were enriched in NF-kB and IL6-JAK-STATA3 signaling pathways. Inhibitors of IL1R1 or CASP4 improved the functional recovery of SCI rats and decreased the expression of inflammatory targets. The findings shed new light on the pathogenesis of SCI and provide potential therapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Si-Jian Huang, Lu-Yao Zhou, Fei Ren, Wang-Yuan Zou, Jian-Qin Yan, Jian-Gang Luo
Summary: Accumulating evidence suggests that nociceptive signals from inflamed tissue can increase the excitability of spinal neurons, contributing to peripheral inflammation. This study aimed to investigate the role of spinal IL-33 in a rat model of arthritis and found that it influences both peripheral inflammation and hyperalgesia. Thus, targeting IL-33 at the spinal level may be a novel therapeutic strategy for painful inflammatory disorders.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Immunology
Mingjie Xia, Yanan Zhang, Honghui Wu, Qinyang Zhang, Qiangxian Liu, Guangshen Li, Tianyu Zhao, Xuepeng Liu, Shengnai Zheng, Zhanyang Qian, Haijun Li
Summary: This study demonstrates that FTS.B effectively attenuates neuro-inflammation and secondary neuronal apoptosis by inhibition of NF-κB and p38-MAPK signaling pathways through activating Nrf2 after SCI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tao Jiang, Tao Qin, Peng Gao, Zhiwen Tao, Xiaowei Wang, Mengyuan Wu, Jun Gu, Bo Chu, Ziyang Zheng, Jiang Yi, Tao Xu, Yifan Huang, Hao Liu, Shujie Zhao, Yongxin Ren, Jian Chen, Guoyong Yin
Summary: The expression of SIRT1 in spinal cord endothelial cells is decreased after spinal cord injury (SCI). SIRT1 has the ability to reduce endothelial reactive oxygen species production and protect endothelial barrier function, indicating its potential as a therapeutic target for promoting functional recovery against blood-spinal cord barrier (BSCB) disruption following SCI.
Meeting Abstract
Gastroenterology & Hepatology
Elise L. Ma, David J. Loane, Marie Hanscom, Bogdan A. Stoica, Alan Faden, Terez Shea-Donohue
Meeting Abstract
Gastroenterology & Hepatology
R. Vadan, S. Iacob, B. Stoica, S. Ichim, M. Lita, T. Manuc, C. Cijevschi, A. Trifan, D. Dobru, E. Dumitru, M. Tantau, C. Brisc, M. Diculescu, C. Gheorghe, L. Gheorghe
JOURNAL OF HEPATOLOGY
(2017)
Article
Immunology
James P. Barrett, Rebecca J. Henry, Sonia Villapol, Bogdan A. Stoica, Alok Kumar, Mark P. Burns, Alan I. Faden, David J. Loane
JOURNAL OF NEUROINFLAMMATION
(2017)
Article
Immunology
Alok Kumar, Bogdan A. Stoica, David J. Loane, Ming Yang, Gelareh Abulwerdi, Niaz Khan, Asit Kumar, Stephen R. Thom, Alan I. Faden
JOURNAL OF NEUROINFLAMMATION
(2017)
Article
Critical Care Medicine
Boris Sabirzhanov, Alan I. Faden, Taryn Aubrecht, Rebecca Henry, Ethan Glaser, Bogdan A. Stoica
JOURNAL OF NEUROTRAUMA
(2018)
Article
Neurosciences
Rebecca J. Henry, Rodney M. Ritzel, James P. Barrett, Sarah J. Doran, Yun Jiao, Jennie B. Leach, Gregory L. Szeto, Junfang Wu, Bogdan A. Stoica, Alan Faden, David J. Loane
JOURNAL OF NEUROSCIENCE
(2020)
Article
Neurosciences
James P. Barrett, Rebecca J. Henry, Kari Ann Shirey, Sarah J. Doran, Oleg D. Makarevich, Rodney M. Ritzel, Victoria A. Meadows, Stefanie N. Vogel, Alan Faden, Bogdan A. Stoica, David J. Loane
JOURNAL OF NEUROSCIENCE
(2020)
Article
Immunology
Marie Hanscom, David J. Loane, Taryn Aubretch, Jenna Leser, Kara Molesworth, Nivedita Hedgekar, Rodney M. Ritzel, Gelareh Abulwerdi, Terez Shea-Donohue, Alan I. Faden
Summary: Intestinal inflammation during chronic experimental TBI causes a sustained systemic immune response and altered autonomic balance that are associated with microglial activation, increased neurodegeneration, and persistent neurological deficits.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Gastroenterology & Hepatology
Kunrong Cheng, Shannon M. Larabee, Mazen Tolaymat, Marie Hanscom, Aaron C. Shang, Alyssa Schledwitz, Shien Hu, Cinthia B. Drachenberg, Min Zhan, Ahmed Chahdi, Jean-Pierre Raufman
Summary: The study showed that beta Pix is essential for normal small intestinal epithelial cell proliferation, villus development, and mucosal resistance to injury. Rho kinase signaling mediated the developmental arrest observed in enteroids derived from beta Pix-deficient small intestinal crypts. These findings provide insights into the role Arhgef7/beta Pix plays in intestinal epithelial homeostasis.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Review
Medicine, Research & Experimental
Marie Hanscom, David J. Loane, Terez Shea-Donohue
Summary: Traumatic brain injury (TBI) is a chronic and progressive disease that not only affects neurological function, but also impacts peripheral organs like the gastrointestinal tract. The brain-gut axis plays a crucial role in shaping post-TBI gastrointestinal issues, with dysautonomia and systemic inflammation contributing to dysmotility and increased mucosal permeability. Understanding this communication is key in developing therapeutic strategies for TBI.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Proceedings Paper
Imaging Science & Photographic Technology
Hsueh-Chien Cheng, Antonio Cardone, Eric Krokos, Bogdan Stoica, Alan Faden, Amitabh Varshney
2017 24TH IEEE INTERNATIONAL CONFERENCE ON IMAGE PROCESSING (ICIP)
(2017)
Proceedings Paper
Engineering, Electrical & Electronic
Bogdan Stoica, Laura Florea, Alexandra Badeanu, Andrei Racovitcanu, Iulian Felea, Corneliu Florea
2017 INTERNATIONAL SYMPOSIUM ON SIGNALS, CIRCUITS AND SYSTEMS (ISSCS)
(2017)
Article
Immunology
Elise L. Ma, Allen D. Smith, Neemesh Desai, Lumei Cheung, Marie Hanscom, Bogdan A. Stoica, David J. Loane, Terez Shea-Donohue, Alan I. Faden
BRAIN BEHAVIOR AND IMMUNITY
(2017)
Meeting Abstract
Critical Care Medicine
Rebecca Henry, David Loane, James Barrett, Sarah Doran, Boris Sabirzhanov, Bogdan Stoica, Faden Alan
JOURNAL OF NEUROTRAUMA
(2017)
Meeting Abstract
Critical Care Medicine
Elise Ma, Allen Smith, Neemesh Desai, Lumei Cheung, Marie Hanscom, Bogdan Stoica, David Loane, Terez Shea-Donohue, Alan Faden
JOURNAL OF NEUROTRAUMA
(2017)