NVP-LDE225, a Potent and Selective SMOOTHENED Antagonist Reduces Melanoma Growth In Vitro and In Vivo

Dual Suppression of the Cyclin-Dependent Kinase Inhibitors CDKN2C and CDKN1A in Human Melanoma

(2012) Ahmad Jalili et al.   JNCI-Journal of the National Cancer Institute

Polo-Like Kinase 1 Is a Potential Therapeutic Target in Human Melanoma

(2011) Ahmad Jalili et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Topical Treatment of Basal Cell Carcinomas in Nevoid Basal Cell Carcinoma Syndrome with a Smoothened Inhibitor

(2011) Hans Skvara et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Resistance to BRAF Inhibition in Melanomas

(2011) David B. Solit et al.   NEW ENGLAND JOURNAL OF MEDICINE

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

(2011) Paul B. Chapman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Acquired Resistance to BRAF Inhibitors Mediated by a RAF Kinase Switch in Melanoma Can Be Overcome by Cotargeting MEK and IGF-1R/PI3K

(2010) Jessie Villanueva et al.   CANCER CELL

Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF

(2010) Sonja J. Heidorn et al.   CELL

Clinical Correlates of NRAS and BRAF Mutations in Primary Human Melanoma

(2010) J. A. Ellerhorst et al.   CLINICAL CANCER RESEARCH

Smoothened as a new therapeutic target for human osteosarcoma

(2010) Masataka Hirotsu et al.   Molecular Cancer

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

(2010) Georgia Hatzivassiliou et al.   NATURE

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

(2010) Cory M. Johannessen et al.   NATURE

Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

(2010) Ramin Nazarian et al.   NATURE

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

(2010) Keith T. Flaherty et al.   NEW ENGLAND JOURNAL OF MEDICINE

Computational Prediction and Experimental Verification of New MAP Kinase Docking Sites and Substrates Including Gli Transcription Factors

(2010) Thomas C. Whisenant et al.   PLoS Computational Biology

Increasing Burden of Melanoma in the United States

(2009) Eleni Linos et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

1-Amino-4-benzylphthalazines as Orally Bioavailable Smoothened Antagonists with Antitumor Activity

(2009) Karen Miller-Moslin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Regulation of the hedgehog signaling by the mitogen-activated protein kinase cascade in gastric cancer

(2009) Motoko Seto et al.   MOLECULAR CARCINOGENESIS

The Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase Inhibitor AZD6244 (ARRY-142886) Induces Growth Arrest in Melanoma Cells and Tumor Regression When Combined with Docetaxel

(2008) N. K. Haass et al.   CLINICAL CANCER RESEARCH

Melanoma Genetics and Therapeutic Approaches in the 21st Century: Moving from the Benchside to the Bedside

(2008) Thomas L. Hocker et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Gene Expression Changes in an Animal Melanoma Model Correlate with Aggressiveness of Human Melanoma Metastases

(2008) L. Xu et al.   MOLECULAR CANCER RESEARCH

Epidemiology and clinical characteristics of ulcerative colitis in Chinese population: Experience from a single center in Hong Kong

(2007) Ka-Ho Lok et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY