Vitamin C boosts DNA demethylation in TET2 germline mutation carriers

TET2 mutations are associated with hypermethylation at key regulatory enhancers in normal and malignant hematopoiesis

(2021) Morten Tulstrup et al.   Nature Communications

Germline TET2 Loss-Of-Function Causes Childhood Immunodeficiency And Lymphoma

(2020) Jarmila Stremenova Spegarova et al.   BLOOD

Context dependent effects of ascorbic acid treatment in TET2 mutant myeloid neoplasia

(2020) Yihong Guan et al.   Communications Biology

Functionally distinct roles for TET-oxidized 5-methylcytosine bases in somatic reprogramming to pluripotency

(2020) Blake A. Caldwell et al.   MOLECULAR CELL

Determining cell type abundance and expression from bulk tissues with digital cytometry

(2019) Aaron M. Newman et al.   NATURE BIOTECHNOLOGY

Clinical remission following ascorbate treatment in a case of acute myeloid leukemia with mutations in TET2 and WT1

(2019) Andrew B. Das et al.   Blood Cancer Journal

Oral vitamin C supplementation to patients with myeloid cancer on azacitidine treatment: Normalization of plasma vitamin C induces epigenetic changes

(2019) Linn Gillberg et al.   Clinical Epigenetics

Familial myeloid malignancies with germline TET2 mutation

(2019) Nicolas Duployez et al.   LEUKEMIA

Minimap2: pairwise alignment for nucleotide sequences

(2018) Heng Li   BIOINFORMATICS

NanoPack: visualizing and processing long-read sequencing data

(2018) Wouter De Coster et al.   BIOINFORMATICS

Transcription Factors Drive Tet2-Mediated Enhancer Demethylation to Reprogram Cell Fate

(2018) Jose Luis Sardina et al.   Cell Stem Cell

Ascorbate regulates haematopoietic stem cell function and leukaemogenesis

(2017) Michalis Agathocleous et al.   NATURE

Detecting DNA cytosine methylation using nanopore sequencing

(2017) Jared T Simpson et al.   NATURE METHODS

The Encyclopedia of DNA elements (ENCODE): data portal update

(2017) Carrie A Davis et al.   NUCLEIC ACIDS RESEARCH

Dysregulation of TET2 in hematologic malignancies

(2016) Shigeru Chiba   INTERNATIONAL JOURNAL OF HEMATOLOGY

Tet2 Catalyzes Stepwise 5-Methylcytosine Oxidation by an Iterative and de novo Mechanism

(2016) Daniel J. Crawford et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mutations along a TET2 active site scaffold stall oxidation at 5-hydroxymethylcytosine

(2016) Monica Yun Liu et al.   Nature Chemical Biology

Active DNA demethylation at enhancers during the vertebrate phylotypic period

(2016) Ozren Bogdanović et al.   NATURE GENETICS

TET2 Mutations Affect Non-CpG Island DNA Methylation at Enhancers and Transcription Factor-Binding Sites in Chronic Myelomonocytic Leukemia

(2015) J. Yamazaki et al.   CANCER RESEARCH

Loss ofTET2in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis

(2015) Kasper D. Rasmussen et al.   GENES & DEVELOPMENT

Integrative analysis of 111 reference human epigenomes

(2015) Anshul Kundaje et al.   NATURE

TET proteins and the control of cytosine demethylation in cancer

(2015) Laurianne Scourzic et al.   Genome Medicine

5mC Oxidation by Tet2 Modulates Enhancer Activity and Timing of Transcriptome Reprogramming during Differentiation

(2014) Gary C. Hon et al.   MOLECULAR CELL

Single-base resolution analysis of active DNA demethylation using methylase-assisted bisulfite sequencing

(2014) Hao Wu et al.   NATURE BIOTECHNOLOGY

Ascorbate Induces Ten-Eleven Translocation (Tet) Methylcytosine Dioxygenase-mediated Generation of 5-Hydroxymethylcytosine

(2013) Emily A. Minor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ascorbic Acid Enhances Tet-Mediated 5-Methylcytosine Oxidation and Promotes DNA Demethylation in Mammals

(2013) Ruichuan Yin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Ten-Eleven Translocation-2 (TET2) gene in hematopoiesis and hematopoietic diseases

(2013) E Solary et al.   LEUKEMIA

Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells

(2013) Kathryn Blaschke et al.   NATURE

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

The SLC23 family of ascorbate transporters: ensuring that you get and keep your daily dose of vitamin C

(2011) James M May   BRITISH JOURNAL OF PHARMACOLOGY

Replication-Dependent Loss of 5-Hydroxymethylcytosine in Mouse Preimplantation Embryos

(2011) A. Inoue et al.   SCIENCE

Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression of myeloproliferative neoplasms

(2010) F. X. Schaub et al.   BLOOD

Chromatin Signatures in Multipotent Human Hematopoietic Stem Cells Indicate the Fate of Bivalent Genes during Differentiation

(2009) Kairong Cui et al.   Cell Stem Cell