DNA damage in testicular germ cells and spermatozoa. When and how is it induced? How should we measure it? What does it mean?

Peroxiredoxin 6 Peroxidase and Ca2+-Independent Phospholipase A2 Activities Are Essential to Support Male-Mouse Fertility

(2022) Edrian Bumanlag et al.   Antioxidants

Male Infertility and Oxidative Stress: A Focus on the Underlying Mechanisms

(2022) Robert John Aitken et al.   Antioxidants

Vitamin C and E supplementation can ameliorate NaF mediated testicular and spermatozoal DNA damages in adult Wistar rats

(2022) Priyankar Pal et al.   BIOMARKERS

De novo mutations in children born after medical assisted reproduction

(2022) R M Smits et al.   HUMAN REPRODUCTION

Role of sperm DNA damage in creating de-novo mutations in human offspring: the ‘post-meiotic oocyte collusion’ hypothesis

(2022) Robert John Aitken   REPRODUCTIVE BIOMEDICINE ONLINE

Potential protective effect of beta-caryophyllene against cadmium chloride-induced damage to the male reproductive system in mouse

(2022) Beatriz A. Espinosa-Ahedo et al.   REPRODUCTIVE TOXICOLOGY

Silymarin abrogates acrylamide‐induced oxidative stress‐mediated testicular toxicity via modulation of antioxidant mechanism, DNA damage, endocrine deficit and sperm quality in rats

(2022) Hissah Ahmed Alturki et al.   ANDROLOGIA

Molecular mechanism behind methamphetamine‐induced damages in testicular tissue: Evidences for oxidative stress, autophagy, and apoptosis

(2022) Tahmineh Peirouvi et al.   ANDROLOGIA

Polystyrene microplastics induce apoptosis and necroptosis in swine testis cells via ROS / MAPK / HIF1α pathway

(2022) Xu Wang et al.   ENVIRONMENTAL TOXICOLOGY

Small Noncoding RNAs Contribute to Sperm Oxidative Stress-Induced Programming of Behavioral and Metabolic Phenotypes in Offspring

(2022) Li Ren et al.   Oxidative Medicine and Cellular Longevity

Dimethyl Sulfoxide Attenuates Radiation-Induced Testicular Injury through Facilitating DNA Double-Strand Break Repair

(2022) Zeze Huang et al.   Oxidative Medicine and Cellular Longevity

Juvenile Exposure and Adult Risk Assessment with Single versus Repeated Exposure of Melphalan in the Germ Cells of Male SD Rat: Deciphering the Molecular Mechanisms

(2022) Archna Panghal et al.   REPRODUCTIVE TOXICOLOGY

The effects and molecular mechanism of heat stress on spermatogenesis and the mitigation measures

(2022) Yuanyuan Gao et al.   Systems Biology in Reproductive Medicine

The protective effect of curcumin on testicular tissue in a cryptorchid rat model

(2022) Shaoguang Feng et al.   Journal of Pediatric Urology

Lutein Can Alleviate Oxidative Stress, Inflammation, and Apoptosis Induced by Excessive Alcohol to Ameliorate Reproductive Damage in Male Rats

(2022) Yebing Zhang et al.   Nutrients

Sub‐chronic restraint stress exposure in adult rats: An insight into possible inhibitory mechanism on testicular function in relation to germ cell dynamics

(2022) Anupam Yadav et al.   ANDROLOGIA

Oxidative Stress Markers and Sperm DNA Fragmentation in Men Recovered from COVID-19

(2022) Anastasiia D. Shcherbitskaia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dietary zinc deficient condition increases the Bisphenol A toxicity in diabetic rat testes

(2022) Chittaranjan Sahu et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Ameliorate effects of resveratrol and l-carnitine on the testicular tissue and sex hormones level in busulfan induced azoospermia rats

(2022) Hananeh Hafezi et al.   THERIOGENOLOGY

Correlations between elevated basal sperm DNA fragmentation and the clinical outcomes in women undergoing IUI

(2022) Chunhui Zhu et al.   Frontiers in Endocrinology

Dynamic regulation of P-TEFb by 7SK snRNP is integral to the DNA damage response to regulate chemotherapy sensitivity

(2022) Yin Fang et al.   iScience

Lactoferrin alleviates spermatogenesis dysfunction caused by bisphenol A and cadmium via ameliorating disordered autophagy, apoptosis and oxidative stress

(2022) Huanshan He et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Should we be measuring DNA damage in human spermatozoa? New light on an old question

(2021) R John Aitken et al.   HUMAN REPRODUCTION

Elevated sperm DNA fragmentation does not predict recurrent implantation failure

(2021) Jordan C. Best et al.   ANDROLOGIA

Differential impact of four sperm preparation techniques on sperm motility, morphology, DNA fragmentation, acrosome status, oxidative stress and mitochondrial activity: a prospective study

(2021) Georges Raad et al.   Andrology

Aging and oxidative stress alter DNA repair mechanisms in male germ cells of superoxide dismutase-1 null mice

(2021) Paulina Nguyen-Powanda et al.   BIOLOGY OF REPRODUCTION

The paternal toolbox for embryo development and health

(2021) Nicoletta Tarozzi et al.   MOLECULAR HUMAN REPRODUCTION

Protective effect of saponin on sperm DNA fragmentation of mice treated with cyclophosphamide

(2021) Mojgan Timar et al.   ANDROLOGIA

Duplications in the G3 domain or switch II region in HRAS identified in patients with Costello syndrome

(2021) Koki Nagai et al.   HUMAN MUTATION

All you need to know about sperm RNAs

(2021) Joana Santiago et al.   HUMAN REPRODUCTION UPDATE

Birth prevalence of achondroplasia: A systematic literature review and meta‐analysis

(2020) Pamela K. Foreman et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Sperm DNA fragmentation is a novel biomarker for early pregnancy loss

(2020) Lesley Haddock et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Diagnosis and treatment of infertility in men: AUA/ASRM guideline part I

(2020) Peter N. Schlegel et al.   FERTILITY AND STERILITY

Effects of Diabetes Mellitus on Sperm Quality in the Db/Db Mouse Model and the Role of the FoxO1 Pathway

(2020) Jisheng Wang et al.   MEDICAL SCIENCE MONITOR

Semen quality and sperm DNA damage associa –revised – final-finalted with oxidative stress in relation to exposure to polycyclic aromatic hydrocarbons

(2019) Hueiwang Anna C. Jeng et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING

What are the effects of vitamin C on sperm functional properties during direct swim-up procedure?

(2019) Georges Raad et al.   ZYGOTE

The association between sperm DNA fragmentation and reproductive outcomes following intrauterine insemination, a meta analysis

(2019) Qing Chen et al.   REPRODUCTIVE TOXICOLOGY

Overlooked roles of DNA damage and maternal age in generating human germline mutations

(2019) Ziyue Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Paternal impacts on development: identification of genomic regions vulnerable to oxidative DNA damage in human spermatozoa

(2019) M J Xavier et al.   HUMAN REPRODUCTION

Proteomic Analysis Reveals that Topoisomerase 2A is Associated with Defective Sperm Head Morphology

(2019) Jacob Netherton et al.   MOLECULAR & CELLULAR PROTEOMICS

Use of testicular sperm for intracytoplasmic sperm injection in men with high sperm DNA fragmentation: a SWOT analysis

(2018) SandroC Esteves et al.   ASIAN JOURNAL OF ANDROLOGY

Accuracy of human sperm DNA oxidation quantification and threshold determination using an 8-OHdG immuno-detection assay

(2018) S Vorilhon et al.   HUMAN REPRODUCTION

Spatiotemporal distribution of small ubiquitin-like modifiers during human placental development and in response to oxidative and inflammatory stress

(2018) Dora Baczyk et al.   JOURNAL OF PHYSIOLOGY-LONDON

Selfish mutations dysregulating RAS-MAPK signaling are pervasive in aged human testes

(2018) Geoffrey J. Maher et al.   GENOME RESEARCH

Reproductive outcomes of testicular versus ejaculated sperm for intracytoplasmic sperm injection among men with high levels of DNA fragmentation in semen: systematic review and meta-analysis

(2017) Sandro C. Esteves et al.   FERTILITY AND STERILITY

Pathogenetics of the RASopathies

(2016) William E. Tidyman et al.   HUMAN MOLECULAR GENETICS

A novel antioxidant formulation designed to treat male infertility associated with oxidative stress: promising preclinical evidence from animal models

(2016) P. Gharagozloo et al.   HUMAN REPRODUCTION

In vitro exposure of human spermatozoa to bisphenol A induces pro-oxidative/apoptotic mitochondrial dysfunction

(2016) Arcangelo Barbonetti et al.   REPRODUCTIVE TOXICOLOGY

Nonylphenol induced apoptosis and autophagy involving the Akt/mTOR pathway in prepubertal Sprague-Dawley male rats in vivo and in vitro

(2016) Wenting Huang et al.   TOXICOLOGY

Tobacco Use Increases Oxidative DNA Damage in Sperm - Possible Etiology of Childhood Cancer

(2015) Shiv Basant Kumar et al.   Asian Pacific Journal of Cancer Prevention

Fertilization stimulates 8-hydroxy-2′-deoxyguanosine repair and antioxidant activity to prevent mutagenesis in the embryo

(2015) Tessa Lord et al.   DEVELOPMENTAL BIOLOGY

Luminal fluid of epididymis and vas deferens contributes to sperm chromatin fragmentation

(2015) Joanna E. Gawecka et al.   HUMAN REPRODUCTION

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(2015) Monica Muratori et al.   MOLECULAR MEDICINE

Sperm DNA oxidative damage and DNA adducts

(2015) Hueiwang Anna Jeng et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

The human transcriptome across tissues and individuals

(2015) M. Mele et al.   SCIENCE

“Selfish Spermatogonial Selection”: A Novel Mechanism for the Association Between Advanced Paternal Age and Neurodevelopmental Disorders

(2013) Anne Goriely et al.   AMERICAN JOURNAL OF PSYCHIATRY

The clinical utility of sperm DNA integrity testing: a guideline

(2013)   FERTILITY AND STERILITY

The presence of a truncated base excision repair pathway in human spermatozoa that is mediated by OGG1

(2013) T. B. Smith et al.   JOURNAL OF CELL SCIENCE

The source and significance of DNA damage in human spermatozoa; a commentary on diagnostic strategies and straw man fallacies

(2013) R. J. Aitken et al.   MOLECULAR HUMAN REPRODUCTION

Comparison of Oxidative Stress/DNA Damage in Semen and Blood of Fertile and Infertile Men

(2013) Jolanta Guz et al.   PLoS One

Paternal Age Effect Mutations and Selfish Spermatogonial Selection: Causes and Consequences for Human Disease

(2012) Anne Goriely et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Enhanced Genetic Integrity in Mouse Germ Cells1

(2012) Patricia Murphey et al.   BIOLOGY OF REPRODUCTION

The effect of sperm DNA fragmentation on miscarriage rates: a systematic review and meta-analysis

(2012) L. Robinson et al.   HUMAN REPRODUCTION

Semen apoptotic M540 body levels correlate with testis abnormalities: a study in a cohort of infertile subjects

(2012) F. Lotti et al.   HUMAN REPRODUCTION

Positive Selection for New Disease Mutations in the Human Germline: Evidence from the Heritable Cancer Syndrome Multiple Endocrine Neoplasia Type 2B

(2012) Soo-Kyung Choi et al.   PLoS Genetics

Phosphoinositide 3-kinase signalling pathway involvement in a truncated apoptotic cascade associated with motility loss and oxidative DNA damage in human spermatozoa

(2011) Adam J. Koppers et al.   BIOCHEMICAL JOURNAL

Starting a new life: Sperm PLC-zeta mobilizes the Ca2+ signal that induces egg activation and embryo development

(2011) Michail Nomikos et al.   BIOESSAYS

Attenuating effect of lycopene and ellagic acid on 2,3,7,8-tetrachlorodibenzo-p-dioxin–induced spermiotoxicity and testicular apoptosis

(2011) Mustafa Sönmez et al.   DRUG AND CHEMICAL TOXICOLOGY

Oxidative deoxyribonucleic acid damage in sperm has a negative impact on clinical pregnancy rate in intrauterine insemination but not intracytoplasmic sperm injection cycles

(2011) Laura Kelly Thomson et al.   FERTILITY AND STERILITY

Analysis of the relationships between oxidative stress, DNA damage and sperm vitality in a patient population: development of diagnostic criteria

(2010) R. J. Aitken et al.   HUMAN REPRODUCTION

DNA Damage in Human Spermatozoa Is Highly Correlated with the Efficiency of Chromatin Remodeling and the Formation of 8-Hydroxy-2′-Deoxyguanosine, a Marker of Oxidative Stress1

(2009) Geoffry N. De Iuliis et al.   BIOLOGY OF REPRODUCTION

Cryopreservation-induced human sperm DNA damage is predominantly mediated by oxidative stress rather than apoptosis

(2009) L.K. Thomson et al.   HUMAN REPRODUCTION

Epididymis seleno-independent glutathione peroxidase 5 maintains sperm DNA integrity in mice

(2009) Eléonore Chabory et al.   JOURNAL OF CLINICAL INVESTIGATION

Gpx5 protects the family jewels

(2009) R. John Aitken   JOURNAL OF CLINICAL INVESTIGATION

Mobile Phone Radiation Induces Reactive Oxygen Species Production and DNA Damage in Human Spermatozoa In Vitro

(2009) Geoffry N. De Iuliis et al.   PLoS One

DNA Damage Response During Chromatin Remodeling in Elongating Spermatids of Mice1

(2007) Frédéric Leduc et al.   BIOLOGY OF REPRODUCTION

The significance of sperm DNA oxidation in embryo development and reproductive outcome in an oocyte donation program: a new model to study a male infertility prognostic factor

(2007) Marcos Meseguer et al.   FERTILITY AND STERILITY

Sperm chromatin structure assay parameters are not related to fertilization rates, embryo quality, and pregnancy rates in in vitro fertilization and intracytoplasmic sperm injection, but might be related to spontaneous abortion rates

(2007) Ming-Huei Lin et al.   FERTILITY AND STERILITY