A novel antioxidant formulation designed to treat male infertility associated with oxidative stress: promising preclinical evidence from animal models

Are sperm capacitation and apoptosis the opposite ends of a continuum driven by oxidative stress?

(2015) RobertJ Aitken et al.   ASIAN JOURNAL OF ANDROLOGY

Curcumin and hydroxamate-derivative (PCI-34058) interfere with histone deacetylase I catalytic core Asp-His charge relay system: atomistic simulation studies

(2015) I. O. Omotuyi et al.   JOURNAL OF MOLECULAR MODELING

Oxidative stress and human spermatozoa: diagnostic and functional significance of aldehydes generated as a result of lipid peroxidation

(2015) Ryan Moazamian et al.   MOLECULAR HUMAN REPRODUCTION

Oxidative stress and male reproductive health

(2014) RobertJ Aitken et al.   ASIAN JOURNAL OF ANDROLOGY

Oxidative Stress in Mouse Sperm Impairs Embryo Development, Fetal Growth and Alters Adiposity and Glucose Regulation in Female Offspring

(2014) Michelle Lane et al.   PLoS One

Sperm DNA damage caused by oxidative stress: modifiable clinical, lifestyle and nutritional factors in male infertility

(2014) C. Wright et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Protective Effect of Resveratrol on Biomarkers of Oxidative Stress Induced by Iron/Ascorbate in Mouse Spermatozoa

(2014) María Mojica-Villegas et al.   Nutrients

The antioxidants dilemma: are they potentially immunosuppressants and carcinogens?

(2014) Soroush Seifirad et al.   Frontiers in Physiology

DNA oxidative damage in mammalian spermatozoa: where and why is the male nucleus affected?

(2013) Anais Noblanc et al.   FREE RADICAL BIOLOGY AND MEDICINE

The presence of a truncated base excision repair pathway in human spermatozoa that is mediated by OGG1

(2013) T. B. Smith et al.   JOURNAL OF CELL SCIENCE

The source and significance of DNA damage in human spermatozoa; a commentary on diagnostic strategies and straw man fallacies

(2013) R. J. Aitken et al.   MOLECULAR HUMAN REPRODUCTION

The senescence-accelerated mouse prone 8 as a model for oxidative stress and impaired DNA repair in the male germ line

(2013) T B Smith et al.   REPRODUCTION

The impact of sperm DNA damage in assisted conception and beyond: recent advances in diagnosis and treatment

(2013) Sheena E.M. Lewis et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Protective role of L-carnitine and vitamin E on the testis of atherosclerotic rats

(2013) Afrah F Salama et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Interaction of aldehydes derived from lipid peroxidation and membrane proteins

(2013) Stefania Pizzimenti et al.   Frontiers in Physiology

The lipid peroxidation product 4-hydroxy-2-nonenal: Advances in chemistry and analysis

(2013) Corinne M. Spickett   Redox Biology

Electrophilic Aldehydes Generated by Sperm Metabolism Activate Mitochondrial Reactive Oxygen Species Generation and Apoptosis by Targeting Succinate Dehydrogenase

(2012) R. John Aitken et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rate of de novo mutations and the importance of father’s age to disease risk

(2012) Augustine Kong et al.   NATURE

Epididymis Response Partly Compensates for Spermatozoa Oxidative Defects in snGPx4 and GPx5 Double Mutant Mice

(2012) Anaïs Noblanc et al.   PLoS One

Sperm DNA damage has a negative association with live-birth rates after IVF

(2012) L. Simon et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Selenium and Lycopene Attenuate Cisplatin-induced Testicular Toxicity Associated With Oxidative Stress in Wistar Rats

(2012) Emad A. Salem et al.   UROLOGY

Phosphoinositide 3-kinase signalling pathway involvement in a truncated apoptotic cascade associated with motility loss and oxidative DNA damage in human spermatozoa

(2011) Adam J. Koppers et al.   BIOCHEMICAL JOURNAL

The role of sperm oxidative stress in male infertility and the significance of oral antioxidant therapy

(2011) P. Gharagozloo et al.   HUMAN REPRODUCTION

Analysis of the relationships between oxidative stress, DNA damage and sperm vitality in a patient population: development of diagnostic criteria

(2010) R. J. Aitken et al.   HUMAN REPRODUCTION

Deficient Tryptophan Catabolism along the Kynurenine Pathway Reveals That the Epididymis Is in a Unique Tolerogenic State

(2010) Aicha Jrad-Lamine et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selection against spermatozoa with fragmented DNA after postovulatory mating depends on the type of damage

(2010) Juan D Hourcade et al.   Reproductive Biology and Endocrinology

Improvement in sperm DNA quality using an oral antioxidant therapy

(2010) Ozlem Tunc et al.   REPRODUCTIVE BIOMEDICINE ONLINE

A systematic review of the effect of oral antioxidants on male infertility

(2010) C. Ross et al.   REPRODUCTIVE BIOMEDICINE ONLINE

DNA Damage in Human Spermatozoa Is Highly Correlated with the Efficiency of Chromatin Remodeling and the Formation of 8-Hydroxy-2′-Deoxyguanosine, a Marker of Oxidative Stress1

(2009) Geoffry N. De Iuliis et al.   BIOLOGY OF REPRODUCTION

A Single, Mild, Transient Scrotal Heat Stress Causes Hypoxia and Oxidative Stress in Mouse Testes, Which Induces Germ Cell Death1

(2009) Catriona Paul et al.   BIOLOGY OF REPRODUCTION

Stimulation of mitochondrial reactive oxygen species production by unesterified, unsaturated fatty acids in defective human spermatozoa

(2009) Adam J. Koppers et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress and medical antioxidant treatment in male infertility

(2009) Francesco M Lanzafame et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Long-Term Effects of Mouse Intracytoplasmic Sperm Injection with DNA-Fragmented Sperm on Health and Behavior of Adult Offspring1

(2008) Raúl Fernández-Gonzalez et al.   BIOLOGY OF REPRODUCTION

Correlation between DNA damage and sperm parameters: a prospective study of 1,633 patients

(2008) Paul Cohen-Bacrie et al.   FERTILITY AND STERILITY

Biological and clinical significance of DNA damage in the male germ line

(2008) R. John Aitken et al.   INTERNATIONAL JOURNAL OF ANDROLOGY

Dose translation from animal to human studies revisited

(2007) Shannon Reagan-Shaw et al.   FASEB JOURNAL