Should we be measuring DNA damage in human spermatozoa? New light on an old question

The impact of parental psychopathology and sociodemographic factors in selective mutism - a nationwide population-based study

(2020) Miina Koskela et al.   BMC Psychiatry

Advanced paternal age is associated with an increased risk of spontaneous miscarriage: a systematic review and meta-analysis

(2020) Nadia A du Fossé et al.   HUMAN REPRODUCTION UPDATE

Parental Age Effects on Neonatal White Matter Development

(2020) Oliver Gale-Grant et al.   NeuroImage-Clinical

Protective effect of the superoxide dismutase mimetic MnTBAP during sperm vitrification process

(2020) Pamela Uribe et al.   ANDROLOGIA

The Sins of Our Forefathers: Paternal Impacts on De Novo Mutation Rate and Development

(2020) R. John Aitken et al.   Annual Review of Genetics

Relationships between the age of 25,445 men attending infertility clinics and sperm chromatin structure assay (SCSA®) defined sperm DNA and chromatin integrity

(2020) Donald P. Evenson et al.   FERTILITY AND STERILITY

Whole‐body heat exposure causes developmental stage‐specific apoptosis of male germ cells

(2020) Jungbin Yoon et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Free circulating DNA and DNase activity in the ejaculates of men with spinal cord injury

(2020) Javier Bartolomé-Nebreda et al.   SPINAL CORD

Birth prevalence of achondroplasia: A systematic literature review and meta‐analysis

(2020) Pamela K. Foreman et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

DNA fragmentation of sperm: a radical examination of the contribution of oxidative stress and age in 16 945 semen samples

(2020) D A Vaughan et al.   HUMAN REPRODUCTION

Association between paternal age and offspring's under‐5 mortality: Data from 159 surveys in 67 low‐ to middle‐income countries

(2020) Han Wu et al.   JOURNAL OF PAEDIATRICS AND CHILD HEALTH

Sperm chromatin condensation and single‐ and double‐stranded DNA damage as important parameters to define male factor related recurrent miscarriage

(2020) Jordi Ribas‐Maynou et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Genetic Instability and Chromatin Remodeling in Spermatids

(2019) Tiphanie Cavé et al.   Genes

Association of four imprinting disorders and ART

(2019) Hiromitsu Hattori et al.   Clinical Epigenetics

What are the effects of vitamin C on sperm functional properties during direct swim-up procedure?

(2019) Georges Raad et al.   ZYGOTE

Maternal, Infant and Childhood Risks Associated with Advanced Paternal Age: The Need for Comprehensive Counseling for Men

(2019) N Phillips et al.   MATURITAS

Parental Age and Differential Estimates of Risk for Neuropsychiatric Disorders: Findings From the Danish Birth Cohort

(2019) Magdalena Janecka et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

Overlooked roles of DNA damage and maternal age in generating human germline mutations

(2019) Ziyue Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Determination of leucocyte extracellular traps (ETs) in seminal fluid (ex vivo ) in infertile patients—A pilot study

(2019) Mabel Schulz et al.   ANDROLOGIA

How 1 h of abstinence improves sperm quality and increases embryo euploidy rate after PGT-A: a study on 106 sibling biopsied blastocysts

(2019) Filomena Scarselli et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Paternal impacts on development: identification of genomic regions vulnerable to oxidative DNA damage in human spermatozoa

(2019) M J Xavier et al.   HUMAN REPRODUCTION

Male ageing is negatively associated with the chance of live birth in IVF/ICSI cycles for idiopathic infertility

(2019) F Horta et al.   HUMAN REPRODUCTION

Melatonin and Caffeine Supplementation Used, Respectively, as Protective and Stimulating Agents in the Cryopreservation of Human Sperm Improves Survival, Viability, and Motility after Thawing compared to Traditional TEST-Yolk Buffer

(2019) Juliana R. Pariz et al.   Oxidative Medicine and Cellular Longevity

Paternal age at birth and metabolic risk factors in adolescents: a nationwide survey

(2019) H.Y. Ahn et al.   PUBLIC HEALTH

Mito-Tempo alleviates cryodamage by regulating intracellular oxidative metabolism in spermatozoa from asthenozoospermic patients

(2019) Xuelian Zhang et al.   CRYOBIOLOGY

Paternal Smoking Before Conception and During Pregnancy Is Associated With an Increased Risk of Childhood Acute Lymphoblastic Leukemia

(2019) Yue Cao et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

Use of testicular sperm for intracytoplasmic sperm injection in men with high sperm DNA fragmentation: a SWOT analysis

(2018) SandroC Esteves et al.   ASIAN JOURNAL OF ANDROLOGY

Advanced parental age as risk factor for childhood acute lymphoblastic leukemia: results from studies of the Childhood Leukemia International Consortium

(2018) Eleni Th. Petridou et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Whole genome sequencing and mutation rate analysis of trios with paternal dioxin exposure

(2018) Nguyen Dang Ton et al.   HUMAN MUTATION

Accuracy of human sperm DNA oxidation quantification and threshold determination using an 8-OHdG immuno-detection assay

(2018) S Vorilhon et al.   HUMAN REPRODUCTION

The effect of paternal factors on perinatal and paediatric outcomes: a systematic review and meta-analysis

(2018) Nan B Oldereid et al.   HUMAN REPRODUCTION UPDATE

Reproductive genetics and the aging male

(2018) Alexander N. Yatsenko et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Japanese Legacy Cohorts: The Life Span Study Atomic Bomb Survivor Cohort and Survivors’ Offspring

(2018) Kotaro Ozasa et al.   JOURNAL OF EPIDEMIOLOGY

Paternal age: Negative impact on sperm genome decays and IVF outcomes after 40 years

(2018) Ismail Kaarouch et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Genomic integrity in the male germ line: evidence in support of the disposable soma hypothesis

(2018) Miguel J Xavier et al.   REPRODUCTION

Cryopreservation media differentially affect sperm motility, morphology and DNA integrity

(2018) G. Raad et al.   Andrology

Reproductive outcomes of testicular versus ejaculated sperm for intracytoplasmic sperm injection among men with high levels of DNA fragmentation in semen: systematic review and meta-analysis

(2017) Sandro C. Esteves et al.   FERTILITY AND STERILITY

Improved sperm kinematics in semen samples collected after 2 h versus 4–7 days of ejaculation abstinence

(2017) H. Alipour et al.   HUMAN REPRODUCTION

Degradation of Extracellular DNA by DNase1 Significantly Reduces Testicular Damage After Testicular Torsion in Rats

(2017) Michael Boettcher et al.   UROLOGY

Effects of Aging and Oxidative Stress on Spermatozoa of Superoxide-Dismutase 1- and Catalase-Null Mice

(2016) J. S. Selvaratnam et al.   BIOLOGY OF REPRODUCTION

Reassuring results on birth outcomes in children fathered by men treated with azathioprine/6-mercaptopurine within 3 months before conception: a nationwide cohort study

(2016) B M Nørgård et al.   GUT

A novel antioxidant formulation designed to treat male infertility associated with oxidative stress: promising preclinical evidence from animal models

(2016) P. Gharagozloo et al.   HUMAN REPRODUCTION

Tobacco Use Increases Oxidative DNA Damage in Sperm - Possible Etiology of Childhood Cancer

(2015) Shiv Basant Kumar et al.   Asian Pacific Journal of Cancer Prevention

Genetic Effect of Chemotherapy Exposure in Children of Testicular Cancer Survivors

(2015) G. V. Kryukov et al.   CLINICAL CANCER RESEARCH

Fertilization stimulates 8-hydroxy-2′-deoxyguanosine repair and antioxidant activity to prevent mutagenesis in the embryo

(2015) Tessa Lord et al.   DEVELOPMENTAL BIOLOGY

Effects of increased paternal age on sperm quality, reproductive outcome and associated epigenetic risks to offspring

(2015) Rakesh Sharma et al.   Reproductive Biology and Endocrinology

Paternal obesity negatively affects male fertility and assisted reproduction outcomes: a systematic review and meta-analysis

(2015) Jared M. Campbell et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Smoking and Male Infertility: An Evidence-Based Review

(2015) Avi Harlev et al.   World Journal of Mens Health

Influence of ejaculatory abstinence on seminal total antioxidant capacity and sperm membrane lipid peroxidation

(2014) Paul B. Marshburn et al.   FERTILITY AND STERILITY

Sperm deoxyribonucleic acid damage in normozoospermic men is related to age and sperm progressive motility

(2014) Stephanie Belloc et al.   FERTILITY AND STERILITY

Association of assisted reproductive technology (ART) treatment and parental infertility diagnosis with autism in ART-conceived children

(2014) D. M. Kissin et al.   HUMAN REPRODUCTION

8-oxoguanine causes spontaneous de novo germline mutations in mice

(2014) Mizuki Ohno et al.   Scientific Reports

Genetic counseling for susceptibility loci and neurodevelopmental disorders: The del15q11.2 as an example

(2013) Veerle De Wolf et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

The clinical utility of sperm DNA integrity testing: a guideline

(2013)   FERTILITY AND STERILITY

Functional deletion of Txndc2 and Txndc3 increases the susceptibility of spermatozoa to age-related oxidative stress

(2013) T.B. Smith et al.   FREE RADICAL BIOLOGY AND MEDICINE

High prevalence of isolated sperm DNA damage in infertile men with advanced paternal age

(2013) Mausumi Das et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

The presence of a truncated base excision repair pathway in human spermatozoa that is mediated by OGG1

(2013) T. B. Smith et al.   JOURNAL OF CELL SCIENCE

The source and significance of DNA damage in human spermatozoa; a commentary on diagnostic strategies and straw man fallacies

(2013) R. J. Aitken et al.   MOLECULAR HUMAN REPRODUCTION

The senescence-accelerated mouse prone 8 as a model for oxidative stress and impaired DNA repair in the male germ line

(2013) T B Smith et al.   REPRODUCTION

Diet and exercise in an obese mouse fed a high-fat diet improve metabolic health and reverse perturbed sperm function

(2012) Nicole O. Palmer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Association between obesity and alteration of sperm DNA integrity and mitochondrial activity

(2012) Roberta M. Fariello et al.   BJU INTERNATIONAL

Cigarette smoke-induced transgenerational alterations in genome stability in cord blood of human F1 offspring

(2012) Julian Laubenthal et al.   FASEB JOURNAL

Diet-induced paternal obesity in the absence of diabetes diminishes the reproductive health of two subsequent generations of mice

(2012) T. Fullston et al.   HUMAN REPRODUCTION

Rate of de novo mutations and the importance of father’s age to disease risk

(2012) Augustine Kong et al.   NATURE

Positive Selection for New Disease Mutations in the Human Germline: Evidence from the Heritable Cancer Syndrome Multiple Endocrine Neoplasia Type 2B

(2012) Soo-Kyung Choi et al.   PLoS Genetics

Phosphoinositide 3-kinase signalling pathway involvement in a truncated apoptotic cascade associated with motility loss and oxidative DNA damage in human spermatozoa

(2011) Adam J. Koppers et al.   BIOCHEMICAL JOURNAL

Shorter abstinence decreases sperm deoxyribonucleic acid fragmentation in ejaculate

(2011) Jaime Gosálvez et al.   FERTILITY AND STERILITY

Electrophoretic sperm isolation: optimization of electrophoresis conditions and impact on oxidative stress

(2011) R. J. Aitken et al.   HUMAN REPRODUCTION

Negative Effect of Increased Body Weight on Sperm Conventional and Nonconventional Flow Cytometric Sperm Parameters

(2011) S. La Vignera et al.   JOURNAL OF ANDROLOGY

Impact of body mass index on seminal oxidative stress

(2010) O. Tunc et al.   ANDROLOGIA

Sperm DNA fragmentation: mechanisms of origin, impact on reproductive outcome, and analysis

(2010) Denny Sakkas et al.   FERTILITY AND STERILITY

DNA Damage in Human Spermatozoa Is Highly Correlated with the Efficiency of Chromatin Remodeling and the Formation of 8-Hydroxy-2′-Deoxyguanosine, a Marker of Oxidative Stress1

(2009) Geoffry N. De Iuliis et al.   BIOLOGY OF REPRODUCTION

Cryopreservation-induced human sperm DNA damage is predominantly mediated by oxidative stress rather than apoptosis

(2009) L.K. Thomson et al.   HUMAN REPRODUCTION

Effect of repeated sequential ejaculation on sperm DNA integrity in subfertile males with asthenozoospermia

(2008) T. M. Hussein et al.   ANDROLOGIA

A germ-line-selective advantage rather than an increased mutation rate can explain some unexpectedly common human disease mutations

(2008) S.-K. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sperm DNA damage is associated with assisted reproductive technology pregnancy

(2007) Hassan W. Bakos et al.   INTERNATIONAL JOURNAL OF ANDROLOGY