Overlooked roles of DNA damage and maternal age in generating human germline mutations
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Title
Overlooked roles of DNA damage and maternal age in generating human germline mutations
Authors
Keywords
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Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 116, Issue 19, Pages 9491-9500
Publisher
Proceedings of the National Academy of Sciences
Online
2019-04-25
DOI
10.1073/pnas.1901259116
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Note: Only part of the references are listed.- DNA Replication and associated repair pathways are involved in the mutagenesis of methylated cytosine
- (2018) Marketa Tomkova et al. DNA REPAIR
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- (2018) Jakob M. Goldmann et al. NATURE GENETICS
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- (2018) Nathaniel P. Sharp et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- Multiple transmissions of de novo mutations in families
- (2018) Hákon Jónsson et al. NATURE GENETICS
- Error-prone bypass of DNA lesions during lagging-strand replication is a common source of germline and cancer mutations
- (2018) Vladimir B. Seplyarskiy et al. NATURE GENETICS
- Parental influence on human germline de novo mutations in 1,548 trios from Iceland
- (2017) Hákon Jónsson et al. NATURE
- Somatic mutations reveal asymmetric cellular dynamics in the early human embryo
- (2017) Young Seok Ju et al. NATURE
- Rates, distribution and implications of postzygotic mosaic mutations in autism spectrum disorder
- (2017) Elaine T Lim et al. NATURE NEUROSCIENCE
- The interaction between cytosine methylation and processes of DNA replication and repair shape the mutational landscape of cancer genomes
- (2017) Rebecca C. Poulos et al. NUCLEIC ACIDS RESEARCH
- Decoding germline de novo point mutations
- (2016) Anne Goriely NATURE GENETICS
- Parent-of-origin-specific signatures of de novo mutations
- (2016) Jakob M Goldmann et al. NATURE GENETICS
- Genetic drift, selection and the evolution of the mutation rate
- (2016) Michael Lynch et al. NATURE REVIEWS GENETICS
- Mutation rates and the evolution of germline structure
- (2016) Aylwyn Scally PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- Life history effects on the molecular clock of autosomes and sex chromosomes
- (2016) Guy Amster et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Variation in the molecular clock of primates
- (2016) Priya Moorjani et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- New observations on maternal age effect on germline de novo mutations
- (2016) Wendy S. W. Wong et al. Nature Communications
- Interpreting the Dependence of Mutation Rates on Age and Time
- (2016) Ziyue Gao et al. PLOS BIOLOGY
- Human Germline Mutation and the Erratic Evolutionary Clock
- (2016) Priya Moorjani et al. PLOS BIOLOGY
- Post-zygotic Point Mutations Are an Underrecognized Source of De Novo Genomic Variation
- (2015) Rocio Acuna-Hidalgo et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Characteristics of de novo structural changes in the human genome
- (2015) Wigard P. Kloosterman et al. GENOME RESEARCH
- Human body epigenome maps reveal noncanonical DNA methylation variation
- (2015) Matthew D. Schultz et al. NATURE
- Genome-wide patterns and properties of de novo mutations in humans
- (2015) Laurent C Francioli et al. NATURE GENETICS
- Timing, rates and spectra of human germline mutation
- (2015) Raheleh Rahbari et al. NATURE GENETICS
- The series elastic shock absorber: tendon elasticity modulates energy dissipation by muscle during burst deceleration
- (2015) N. Konow et al. PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- Epigenetic and transcriptional determinants of the human breast
- (2015) Philippe Gascard et al. Nature Communications
- Genome-Wide Estimates of Mutation Rates and Spectrum in Schizosaccharomyces pombe Indicate CpG Sites are Highly Mutagenic Despite the Absence of DNA Methylation
- (2015) Megan G. Behringer et al. G3-Genes Genomes Genetics
- Age-Specific Gene Expression Profiles of Rhesus Monkey Ovaries Detected by Microarray Analysis
- (2015) Hengxi Wei et al. Biomed Research International
- Determinants of Mutation Rate Variation in the Human Germline
- (2014) Laure Ségurel et al. Annual Review of Genomics and Human Genetics
- Postzygotic single-nucleotide mosaicisms in whole-genome sequences of clinically unremarkable individuals
- (2014) August Y Huang et al. CELL RESEARCH
- Early postzygotic mutations contribute to de novo variation in a healthy monozygotic twin pair
- (2014) Gülşah M Dal et al. JOURNAL OF MEDICAL GENETICS
- Precise estimates of mutation rate and spectrum in yeast
- (2014) Y. O. Zhu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Strong male bias drives germline mutation in chimpanzees
- (2014) O. Venn et al. SCIENCE
- 8-oxoguanine causes spontaneous de novo germline mutations in mice
- (2014) Mizuki Ohno et al. Scientific Reports
- The origin, evolution, and functional impact of short insertion-deletion variants identified in 179 human genomes
- (2013) S. B. Montgomery et al. GENOME RESEARCH
- High-resolution DNA methylome analysis of primordial germ cells identifies gender-specific reprogramming in mice
- (2013) H. Kobayashi et al. GENOME RESEARCH
- The presence of a truncated base excision repair pathway in human spermatozoa that is mediated by OGG1
- (2013) T. B. Smith et al. JOURNAL OF CELL SCIENCE
- Impairment of BRCA1-Related DNA Double-Strand Break Repair Leads to Ovarian Aging in Mice and Humans
- (2013) S. Titus et al. Science Translational Medicine
- Rate of de novo mutations and the importance of father’s age to disease risk
- (2012) Augustine Kong et al. NATURE
- DO VARIATIONS IN SUBSTITUTION RATES AND MALE MUTATION BIAS CORRELATE WITH LIFE-HISTORY TRAITS? A STUDY OF 32 MAMMALIAN GENOMES
- (2011) Melissa A. Wilson Sayres et al. EVOLUTION
- Oxidative Damage Increases and Antioxidant Gene Expression Decreases with Aging in the Mouse Ovary
- (2010) J. Lim et al. BIOLOGY OF REPRODUCTION
- Evolution of the mutation rate
- (2010) Michael Lynch TRENDS IN GENETICS
- DNA Damage in Human Spermatozoa Is Highly Correlated with the Efficiency of Chromatin Remodeling and the Formation of 8-Hydroxy-2′-Deoxyguanosine, a Marker of Oxidative Stress1
- (2009) Geoffry N. De Iuliis et al. BIOLOGY OF REPRODUCTION
- Human DNA methylomes at base resolution show widespread epigenomic differences
- (2009) Ryan Lister et al. NATURE
- Transcriptome Profiling of Human Pre-Implantation Development
- (2009) Pu Zhang et al. PLoS One
- Cryptic Variation in the Human Mutation Rate
- (2009) Alan Hodgkinson et al. PLOS BIOLOGY
- Mutations of Different Molecular Origins Exhibit Contrasting Patterns of Regional Substitution Rate Variation
- (2008) Navin Elango et al. PLoS Computational Biology
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