Quantifying the origins of population variability in cardiac electrical activity through sensitivity analysis of the electrocardiogram

Blocking Scn10a Channels in Heart Reduces Late Sodium Current and Is Antiarrhythmic

(2012) Tao Yang et al.   CIRCULATION RESEARCH

Epistatic Effects of Potassium Channel Variation on Cardiac Repolarization and Atrial Fibrillation Risk

(2012) Stefan A. Mann et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Systems biology and cardiac arrhythmias

(2012) Andrew A Grace et al.   LANCET

Evolution and Functional Impact of Rare Coding Variation from Deep Sequencing of Human Exomes

(2012) J. A. Tennessen et al.   SCIENCE

An Abundance of Rare Functional Variants in 202 Drug Target Genes Sequenced in 14,002 People

(2012) M. R. Nelson et al.   SCIENCE

Heritability of Tpeak-Tend Interval and T-Wave Amplitude

(2011) Christian Haarmark et al.   Circulation-Cardiovascular Genetics

Counterpoint: M cells do not have a functional role in the ventricular myocardium of the intact heart

(2011) Michiel J. Janse et al.   HEART RHYTHM

Point: M cells are present in the ventricular myocardium

(2011) Lance D. Wilson et al.   HEART RHYTHM

T-wave morphology abnormalities in benign, potent, and arrhythmogenic Ikr inhibition

(2011) Jean-Philippe Couderc et al.   HEART RHYTHM

Quantification of repolarization reserve to understand interpatient variability in the response to proarrhythmic drugs: A computational analysis

(2011) Amrita X. Sarkar et al.   HEART RHYTHM

Cardiac simulation on multi-GPU platform

(2011) Venkata Krishna Nimmagadda et al.   JOURNAL OF SUPERCOMPUTING

Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation

(2011) Thomas O'Hara et al.   PLoS Computational Biology

Transmural Dispersion of Repolarization in Failing and Nonfailing Human Ventricle

(2010) Alexey V. Glukhov et al.   CIRCULATION RESEARCH

Parameter Sensitivity Analysis in Electrophysiological Models Using Multivariable Regression

(2009) Eric A. Sobie   BIOPHYSICAL JOURNAL

The QT interval: Too long, too short or just right

(2009) Sami Viskin   HEART RHYTHM

Not All hERG Pore Domain Mutations Have a Severe Phenotype: G584S Has an Inactivation Gating Defect with Mild Phenotype Compared to G572S, Which Has a Dominant Negative Trafficking Defect and a Severe Phenotype

(2009) JING TING ZHAO et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Genetic Association Studies

(2008) Kathryn L. Lunetta   CIRCULATION

A genetic framework for improving arrhythmia therapy

(2008) Björn C. Knollmann et al.   NATURE