Multiscale cardiac modelling reveals the origins of notched T waves in long QT syndrome type 2

In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome

(2014) Lucia Romero et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

hERG Inhibitors with Similar Potency But Different Binding Kinetics Do Not Pose the Same Proarrhythmic Risk: Implications for Drug Safety Assessment

(2013) GIOVANNI Y. DI VEROLI et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Quantifying the origins of population variability in cardiac electrical activity through sensitivity analysis of the electrocardiogram

(2013) Arash Sadrieh et al.   JOURNAL OF PHYSIOLOGY-LONDON

Computational methods to reduce uncertainty in the estimation of cardiac conduction properties from electroanatomical recordings

(2013) Mikael Wallman et al.   MEDICAL IMAGE ANALYSIS

Experimentally calibrated population of models predicts and explains intersubject variability in cardiac cellular electrophysiology

(2013) Oliver J. Britton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chaste: An Open Source C++ Library for Computational Physiology and Biology

(2013) Gary R. Mirams et al.   PLoS Computational Biology

ICH E14 Q & A (R1) document: perspectives on the updated recommendations on thorough QT studies

(2012) Rashmi R. Shah et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Blocking Scn10a Channels in Heart Reduces Late Sodium Current and Is Antiarrhythmic

(2012) Tao Yang et al.   CIRCULATION RESEARCH

Simulations of Complex and Microscopic Models of Cardiac Electrophysiology Powered by Multi-GPU Platforms

(2012) Bruno Gouvêa de Barros et al.   Computational and Mathematical Methods in Medicine

Exploiting mathematical models to illuminate electrophysiological variability between individuals

(2012) Amrita X. Sarkar et al.   JOURNAL OF PHYSIOLOGY-LONDON

Epistatic Effects of Potassium Channel Variation on Cardiac Repolarization and Atrial Fibrillation Risk

(2012) Stefan A. Mann et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

An Abundance of Rare Functional Variants in 202 Drug Target Genes Sequenced in 14,002 People

(2012) M. R. Nelson et al.   SCIENCE

Counterpoint: M cells do not have a functional role in the ventricular myocardium of the intact heart

(2011) Michiel J. Janse et al.   HEART RHYTHM

Point: M cells are present in the ventricular myocardium

(2011) Lance D. Wilson et al.   HEART RHYTHM

Exome sequencing as a tool for Mendelian disease gene discovery

(2011) Michael J. Bamshad et al.   NATURE REVIEWS GENETICS

Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation

(2011) Thomas O'Hara et al.   PLoS Computational Biology

A unique digital electrocardiographic repository for the development of quantitative electrocardiography and cardiac safety: the Telemetric and Holter ECG Warehouse (THEW)

(2010) Jean-Philippe Couderc   JOURNAL OF ELECTROCARDIOLOGY

Gender-related differences in ion-channel and transporter subunit expression in non-diseased human hearts

(2010) Nathalie Gaborit et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

A numerical guide to the solution of the bidomain equations of cardiac electrophysiology

(2010) Pras Pathmanathan et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Parameter Sensitivity Analysis in Electrophysiological Models Using Multivariable Regression

(2009) Eric A. Sobie   BIOPHYSICAL JOURNAL

Reference values of electrocardiogram repolarization variables in a healthy population

(2009) Christian Haarmark et al.   JOURNAL OF ELECTROCARDIOLOGY

Acceleration of cardiac tissue simulation with graphic processing units

(2009) Daisuke Sato et al.   MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING

Multiscale modelling of drug-induced effects on cardiac electrophysiological activity

(2008) T. Brennan et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Recurrent intrauterine fetal loss due to near absence of HERG: Clinical and functional characterization of a homozygous nonsense HERG Q1070X mutation

(2008) Zahurul A. Bhuiyan et al.   HEART RHYTHM