Improving cardiomyocyte model fidelity and utility via dynamic electrophysiology protocols and optimization algorithms

Predicting the risk of sudden cardiac death

(2016) Claudia Lerma et al.   JOURNAL OF PHYSIOLOGY-LONDON

Lessons from computer simulations of ablation of atrial fibrillation

(2016) Vincent Jacquemet   JOURNAL OF PHYSIOLOGY-LONDON

Intermittent drivers anchoring to structural heterogeneities as a major pathophysiological mechanism of human persistent atrial fibrillation

(2016) Michel Haissaguerre et al.   JOURNAL OF PHYSIOLOGY-LONDON

The pioneering work of George Mines on cardiac arrhythmias: groundbreaking ideas that remain influential in contemporary cardiac electrophysiology

(2016) Martin Aguilar et al.   JOURNAL OF PHYSIOLOGY-LONDON

Cell-Specific Cardiac Electrophysiology Models

(2015) Willemijn Groenendaal et al.   PLoS Computational Biology

Virtual Electrophysiological Study of Atrial Fibrillation in Fibrotic Remodeling

(2015) Kathleen S. McDowell et al.   PLoS One

Mathematical Approaches to Understanding and Imaging Atrial Fibrillation

(2014) Natalia A. Trayanova   CIRCULATION RESEARCH

Structural contributions to fibrillatory rotors in a patient-derived computational model of the atria

(2014) M. J. Gonzales et al.   EUROPACE

Inter-Subject Variability in Human Atrial Action Potential in Sinus Rhythm versus Chronic Atrial Fibrillation

(2014) Carlos Sánchez et al.   PLoS One

Fitting Membrane Resistance along with Action Potential Shape in Cardiac Myocytes Improves Convergence: Application of a Multi-Objective Parallel Genetic Algorithm

(2014) Jaspreet Kaur et al.   PLoS One

Optimisation of Ionic Models to Fit Tissue Action Potentials: Application to 3D Atrial Modelling

(2013) Amr Al Abed et al.   Computational and Mathematical Methods in Medicine

Experimentally calibrated population of models predicts and explains intersubject variability in cardiac cellular electrophysiology

(2013) Oliver J. Britton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Computational approaches to understand cardiac electrophysiology and arrhythmias

(2012) Byron N. Roberts et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

“Good Enough Solutions” and the Genetics of Complex Diseases

(2012) James N. Weiss et al.   CIRCULATION RESEARCH

Mechanisms of Human Atrial Fibrillation Initiation

(2012) David E. Krummen et al.   Circulation-Arrhythmia and Electrophysiology

Focal impulse and rotor modulation ablation of sustaining rotors abruptly terminates persistent atrial fibrillation to sinus rhythm with elimination on follow-up: A video case study

(2012) Sanjiv M. Narayan et al.   HEART RHYTHM

Identification of the Parameters of the Beeler–Reuter Ionic Equation With a Partially Perturbed Particle Swarm Optimization

(2012) Fulong Chen et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Personalization of Atrial Anatomy and Electrophysiology as a Basis for Clinical Modeling of Radio-Frequency Ablation of Atrial Fibrillation

(2012) M. W. Krueger et al.   IEEE TRANSACTIONS ON MEDICAL IMAGING

At the heart of computational modelling

(2012) S. A. Niederer et al.   JOURNAL OF PHYSIOLOGY-LONDON

Exploiting mathematical models to illuminate electrophysiological variability between individuals

(2012) Amrita X. Sarkar et al.   JOURNAL OF PHYSIOLOGY-LONDON

How the Hodgkin-Huxley equations inspired the Cardiac Physiome Project

(2012) Denis Noble et al.   JOURNAL OF PHYSIOLOGY-LONDON

Computational modeling of the human atrial anatomy and electrophysiology

(2012) Olaf Dössel et al.   MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING

Rapid Genetic Algorithm Optimization of a Mouse Computational Model: Benefits for Anthropomorphization of Neonatal Mouse Cardiomyocytes

(2012) Corina T. Bot et al.   Frontiers in Physiology

Variability, compensation, and modulation in neurons and circuits

(2011) E. Marder   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inter-model consistency and complementarity: Learning from ex-vivo imaging and electrophysiological data towards an integrated understanding of cardiac physiology

(2011) O. Camara et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

3D virtual human atria: A computational platform for studying clinical atrial fibrillation

(2011) Oleg V. Aslanidi et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation

(2011) Thomas O'Hara et al.   PLoS Computational Biology

How different two almost identical action potentials can be: A model study on cardiac repolarization

(2010) Massimiliano Zaniboni et al.   MATHEMATICAL BIOSCIENCES

Models of cardiac tissue electrophysiology: Progress, challenges and open questions

(2010) R.H. Clayton et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Cardiac cell modelling: Observations from the heart of the cardiac physiome project

(2010) Martin Fink et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Regression Analysis for Constraining Free Parameters in Electrophysiological Models of Cardiac Cells

(2010) Amrita X. Sarkar et al.   PLoS Computational Biology

Identification of I Kr Kinetics and Drug Binding in Native Myocytes

(2009) Qinlian Zhou et al.   ANNALS OF BIOMEDICAL ENGINEERING

A meta-analysis of cardiac electrophysiology computational models

(2009) S. A. Niederer et al.   EXPERIMENTAL PHYSIOLOGY

Markov models for ion channels: versatility versus identifiability and speed

(2009) M. Fink et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Minimal model for human ventricular action potentials in tissue

(2008) Alfonso Bueno-Orovio et al.   JOURNAL OF THEORETICAL BIOLOGY

Dynamics of human atrial cell models: Restitution, memory, and intracellular calcium dynamics in single cells

(2008) Elizabeth M. Cherry et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY