Regulation of neuronal chloride homeostasis by neuromodulators

Allosteric modulation of metabotropic glutamate receptors by chloride ions

(2015) Amélie S. Tora et al.   FASEB JOURNAL

KCC2 regulates actin dynamics in dendritic spines via interaction with β-PIX

(2015) Olaya Llano et al.   JOURNAL OF CELL BIOLOGY

Selective Inhibition of KCC2 Leads to Hyperexcitability and Epileptiform Discharges in Hippocampal Slices and In Vivo

(2015) S. Sivakumaran et al.   JOURNAL OF NEUROSCIENCE

Engagement of the GABA to KCC2 Signaling Pathway Contributes to the Analgesic Effects of A3AR Agonists in Neuropathic Pain

(2015) Amanda Ford et al.   JOURNAL OF NEUROSCIENCE

Crystal structure of human glycine receptor-α3 bound to antagonist strychnine

(2015) Xin Huang et al.   NATURE

The I-TASSER Suite: protein structure and function prediction

(2015) Jianyi Yang et al.   NATURE METHODS

Homeostatic regulation of KCC2 activity by the zinc receptor mZnR/GPR39 during seizures

(2015) David Gilad et al.   NEUROBIOLOGY OF DISEASE

KCC2 activity is critical in limiting the onset and severity of status epilepticus

(2015) Liliya Silayeva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism

(2015) Olga Peñagarikano et al.   Science Translational Medicine

The KCl-cotransporter KCC2 linked to epilepsy

(2014) C. A. Hubner   EMBO REPORTS

The Developmental Switch in GABA Polarity Is Delayed in Fragile X Mice

(2014) Q. He et al.   JOURNAL OF NEUROSCIENCE

Cortical HCN channels: function, trafficking and plasticity

(2014) Mala M. Shah   JOURNAL OF PHYSIOLOGY-LONDON

Cation-chloride cotransporters in neuronal development, plasticity and disease

(2014) Kai Kaila et al.   NATURE REVIEWS NEUROSCIENCE

Oxytocin-Mediated GABA Inhibition During Delivery Attenuates Autism Pathogenesis in Rodent Offspring

(2014) R. Tyzio et al.   SCIENCE

Current view on the functional regulation of the neuronal K+-Cl− cotransporter KCC2

(2014) Igor Medina et al.   Frontiers in Cellular Neuroscience

Kainate Receptors Coexist in a Functional Complex with KCC2 and Regulate Chloride Homeostasis in Hippocampal Neurons

(2014) Vivek Mahadevan et al.   Cell Reports

Disrupted Cl−homeostasis contributes to reductions in the inhibitory efficacy of diazepam during hyperexcited states

(2013) Tarek Z. Deeb et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Activity-Dependent Regulation of the K/Cl Transporter KCC2 Membrane Diffusion, Clustering, and Function in Hippocampal Neurons

(2013) I. Chamma et al.   JOURNAL OF NEUROSCIENCE

Chloride extrusion enhancers as novel therapeutics for neurological diseases

(2013) Martin Gagnon et al.   NATURE MEDICINE

Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl− homeostasis

(2013) Francesco Ferrini et al.   NATURE NEUROSCIENCE

Neto2 is a KCC2 interacting protein required for neuronal Cl−regulation in hippocampal neurons

(2013) Evgueni A. Ivakine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxytocin enhances brain function in children with autism

(2013) I. Gordon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of neuronal activity by phosphorylation of the K–Cl cotransporter KCC2

(2013) Kristopher T. Kahle et al.   TRENDS IN NEUROSCIENCES

Muscarinic acetylcholine receptor activation prevents disinhibition-mediated LTP in the hippocampus

(2013) Petri Takkala et al.   Frontiers in Cellular Neuroscience

Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: Development of a highly selective and more potent in vitro probe

(2012) Eric Delpire et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

N-Methyl-d-aspartate Receptor- and Calpain-mediated Proteolytic Cleavage of K+-Cl−Cotransporter-2 Impairs Spinal Chloride Homeostasis in Neuropathic Pain

(2012) Hong-Yi Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutamate Receptor  2 Associates with Metabotropic Glutamate Receptor 1 (mGluR1), Protein Kinase C , and Canonical Transient Receptor Potential 3 and Regulates mGluR1-Mediated Synaptic Transmission in Cerebellar Purkinje Neurons

(2012) A. S. Kato et al.   JOURNAL OF NEUROSCIENCE

Transcript-Specific Associations of SLC12A5 (KCC2) in Human Prefrontal Cortex with Development, Schizophrenia, and Affective Disorders

(2012) R. Tao et al.   JOURNAL OF NEUROSCIENCE

Activity-Dependent Cleavage of the K-Cl Cotransporter KCC2 Mediated by Calcium-Activated Protease Calpain

(2012) M. Puskarjov et al.   JOURNAL OF NEUROSCIENCE

SNARE-dependent upregulation of potassium chloride co-transporter 2 activity after metabotropic zinc receptor activation in rat cortical neurons in vitro

(2012) R.A. Saadi et al.   NEUROSCIENCE

Activation of 5-HT2A receptors upregulates the function of the neuronal K-Cl cotransporter KCC2

(2012) R. Bos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of the neuronal K-Cl co-transporter KCC2 in inhibitory and excitatory neurotransmission

(2012) Ingrid Chamma et al.   Frontiers in Cellular Neuroscience

Upregulation of KCC2 Activity by Zinc-Mediated Neurotransmission via the mZnR/GPR39 Receptor

(2011) E. Chorin et al.   JOURNAL OF NEUROSCIENCE

NMDA receptor activity downregulates KCC2 resulting in depolarizing GABAA receptor–mediated currents

(2011) Henry H C Lee et al.   NATURE NEUROSCIENCE

Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine

(2011) Andreas Meyer-Lindenberg et al.   NATURE REVIEWS NEUROSCIENCE

The Sound of Silence: Ionic Mechanisms Encoding Sound Termination

(2011) Cornelia Kopp-Scheinpflug et al.   NEURON

How Inhibition Shapes Cortical Activity

(2011) Jeffry S. Isaacson et al.   NEURON

The neuronal K-Cl cotransporter KCC2 influences postsynaptic AMPA receptor content and lateral diffusion in dendritic spines

(2011) G. Gauvain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disinhibition-Mediated LTP in the Hippocampus is Synapse Specific

(2011) Jake Ormond et al.   Frontiers in Cellular Neuroscience

Ih-mediated depolarization enhances the temporal precision of neuronal integration

(2011) Ivan Pavlov et al.   Nature Communications

Selective Participation of Somatodendritic HCN Channels in Inhibitory But Not Excitatory Synaptic Integration in Neurons of the Subthalamic Nucleus

(2010) J. F. Atherton et al.   JOURNAL OF NEUROSCIENCE

Tyrosine phosphorylation regulates the membrane trafficking of the potassium chloride co-transporter KCC2

(2010) Henry H.C. Lee et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

I-TASSER: a unified platform for automated protein structure and function prediction

(2010) Ambrish Roy et al.   Nature Protocols

Loss of Dendritic HCN1 Subunits Enhances Cortical Excitability and Epileptogenesis

(2009) Z. Huang et al.   JOURNAL OF NEUROSCIENCE

GPR50 interacts with neuronal NOGO-A and affects neurite outgrowth

(2009) Ellen Grünewald et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Altered chloride homeostasis removes synaptic inhibitory constraint of the stress axis

(2009) Sarah A Hewitt et al.   NATURE NEUROSCIENCE

Hyperpolarization-Activated Cation Channels: From Genes to Function

(2009) Martin Biel et al.   PHYSIOLOGICAL REVIEWS

Disinhibition Mediates a Form of Hippocampal Long-Term Potentiation in Area CA1

(2009) Jake Ormond et al.   PLoS One

Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2

(2009) E. Delpire et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and Mechanism of a Na+-Independent Amino Acid Transporter

(2009) P. L. Shaffer et al.   SCIENCE

X-ray Structure of the C-Terminal Domain of a Prokaryotic Cation-Chloride Cotransporter

(2009) Stefan Warmuth et al.   STRUCTURE

Tonic activation of group I mGluRs modulates inhibitory synaptic strength by regulating KCC2 activity

(2008) Tue G. Banke et al.   JOURNAL OF PHYSIOLOGY-LONDON

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

(2008) P. Jeffrey Conn et al.   NATURE REVIEWS DRUG DISCOVERY

Diminished plasma oxytocin in schizophrenic patients with neuroendocrine dysfunction and emotional deficits

(2007) Morris Goldman et al.   SCHIZOPHRENIA RESEARCH