Disrupted Cl−homeostasis contributes to reductions in the inhibitory efficacy of diazepam during hyperexcited states

Muscarinic acetylcholine receptor activation prevents disinhibition-mediated LTP in the hippocampus

(2013) Petri Takkala et al.   Frontiers in Cellular Neuroscience

The outcome of therapies in refractory and super-refractory convulsive status epilepticus and recommendations for therapy

(2012) S. Shorvon et al.   BRAIN

Hyperpolarizing GABAergic transmission depends on KCC2 function and membrane potential

(2012) Tarek Z. Deeb et al.   Channels

Activity-dependent phosphorylation of GABAAreceptors regulates receptor insertion and tonic current

(2012) Richard S Saliba et al.   EMBO JOURNAL

The extracellular space and epileptic activity in the adult brain: Explaining the antiepileptic effects of furosemide and bumetanide

(2012) Daryl W. Hochman   EPILEPSIA

Loop Diuretic and Ion-binding Residues Revealed by Scanning Mutagenesis of Transmembrane Helix 3 (TM3) of Na-K-Cl Cotransporter (NKCC1)

(2012) Suma Somasekharan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stabilization of GABAA Receptors at Endocytic Zones Is Mediated by an AP2 Binding Motif within the GABAA Receptor  3 Subunit

(2012) K. R. Smith et al.   JOURNAL OF NEUROSCIENCE

Cation-chloride cotransporters NKCC1 and KCC2 as potential targets for novel antiepileptic and antiepileptogenic treatments

(2012) Wolfgang Löscher et al.   NEUROPHARMACOLOGY

Gephyrin-Independent GABAAR Mobility and Clustering during Plasticity

(2012) Fumihiro Niwa et al.   PLoS One

Computational Modeling Reveals Dendritic Origins of GABAA-Mediated Excitation in CA1 Pyramidal Neurons

(2012) Naomi Lewin et al.   PLoS One

NMDA receptor activity downregulates KCC2 resulting in depolarizing GABAA receptor–mediated currents

(2011) Henry H C Lee et al.   NATURE NEUROSCIENCE

Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes

(2011) Uwe Rudolph et al.   NATURE REVIEWS DRUG DISCOVERY

Ih-mediated depolarization enhances the temporal precision of neuronal integration

(2011) Ivan Pavlov et al.   Nature Communications

Efficacy of Synaptic Inhibition Depends on Multiple, Dynamically Interacting Mechanisms Implicated in Chloride Homeostasis

(2011) Nicolas Doyon et al.   PLoS Computational Biology

Prototypic Seizure Activity Driven by Mature Hippocampal Fast-Spiking Interneurons

(2010) Y. Fujiwara-Tsukamoto et al.   JOURNAL OF NEUROSCIENCE

The K+-Cl−cotransporter KCC2 promotes GABAergic excitation in the mature rat hippocampus

(2010) Tero Viitanen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after stroke

(2010) Andrew N. Clarkson et al.   NATURE

NMDA receptors regulate GABAA receptor lateral mobility and clustering at inhibitory synapses through serine 327 on the  2 subunit

(2010) J. Muir et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Downregulation of Potassium Chloride Cotransporter KCC2 After Transient Focal Cerebral Ischemia

(2010) Nadine Jaenisch et al.   STROKE

The impact of diazepam’s discovery on the treatment and understanding of status epilepticus

(2009) Howard P. Goodkin et al.   EPILEPSIA

Cation-Chloride Cotransporters and Neuronal Function

(2009) Peter Blaesse et al.   NEURON

Activity-Dependent Tuning of Inhibitory Neurotransmission Based on GABAAR Diffusion Dynamics

(2009) Hiroko Bannai et al.   NEURON

Down-regulation of K+–Cl− co-transporter 2 in mouse medullary dorsal horn contributes to the formalin-induced inflammatory orofacial pain

(2009) Li-An Wu et al.   NEUROSCIENCE LETTERS

γ-Aminobutyric Acid (GABA) and Pentobarbital Induce Different Conformational Rearrangements in the GABAAReceptor α1and β2Pre-M1 Regions

(2008) Jose Mercado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deficits in Phosphorylation of GABAA Receptors by Intimately Associated Protein Kinase C Activity Underlie Compromised Synaptic Inhibition during Status Epilepticus

(2008) M. Terunuma et al.   JOURNAL OF NEUROSCIENCE

Subunit-Specific Trafficking of GABAA Receptors during Status Epilepticus

(2008) H. P. Goodkin et al.   JOURNAL OF NEUROSCIENCE

Spinal cord injury-induced attenuation of GABAergic inhibition in spinal dorsal horn circuits is associated with down-regulation of the chloride transporter KCC2 in rat

(2008) Yan Lu et al.   JOURNAL OF PHYSIOLOGY-LONDON

Neuroprotection for ischemic stroke: Past, present and future

(2008) Myron D. Ginsberg   NEUROPHARMACOLOGY

Relationship between neuronal vulnerability and potassium-chloride cotransporter 2 immunoreactivity in hippocampus following transient forebrain ischemia

(2008) E. Papp et al.   NEUROSCIENCE

Sustained depolarizing shift of the GABA reversal potential by glutamate receptor activation in hippocampal neurons

(2008) Akihiko Kitamura et al.   NEUROSCIENCE RESEARCH