Cortical HCN channels: function, trafficking and plasticity

Binding of the auxiliary subunit TRIP8b to HCN channels shifts the mode of action of cAMP

(2013) Lei Hu et al.   JOURNAL OF GENERAL PHYSIOLOGY

Short- and long-term plasticity in CA1 neurons from mice lacking h-channel auxiliary subunit TRIP8b

(2013) Darrin H. Brager et al.   JOURNAL OF NEUROPHYSIOLOGY

Prefrontal Cortex HCN1 Channels Enable Intrinsic Persistent Neural Firing and Executive Memory Function

(2013) S. J. Thuault et al.   JOURNAL OF NEUROSCIENCE

Temporal synchrony and gamma-to-theta power conversion in the dendrites of CA1 pyramidal neurons

(2013) Sachin P Vaidya et al.   NATURE NEUROSCIENCE

Novel HCN2 Mutation Contributes to Febrile Seizures by Shifting the Channel's Kinetics in a Temperature-Dependent Manner

(2013) Yuki Nakamura et al.   PLoS One

TRIP8b-Independent Trafficking and Plasticity of Adult Cortical Presynaptic HCN1 Channels

(2012) Z. Huang et al.   JOURNAL OF NEUROSCIENCE

Regulation of Axonal HCN1 Trafficking in Perforant Path Involves Expression of Specific TRIP8b Isoforms

(2012) Wiebke Wilkars et al.   PLoS One

Impaired Dendritic Expression and Plasticity of h-Channels in the fmr1−/y Mouse Model of Fragile X Syndrome

(2012) Darrin H. Brager et al.   Cell Reports

Neuron-restrictive silencer factor-mediated hyperpolarization-activated cyclic nucleotide gated channelopathy in experimental temporal lobe epilepsy

(2011) Shawn McClelland et al.   ANNALS OF NEUROLOGY

Towards an integrated view of HCN channel role in epilepsy

(2011) Yoav Noam et al.   CURRENT OPINION IN NEUROBIOLOGY

Trafficking and Gating of Hyperpolarization-activated Cyclic Nucleotide-gated Channels Are Regulated by Interaction with Tetratricopeptide Repeat-containing Rab8b-interacting Protein (TRIP8b) and Cyclic AMP at Distinct Sites

(2011) Ye Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Corticospinal-specific HCN expression in mouse motor cortex: Ih-dependent synaptic integration as a candidate microcircuit mechanism involved in motor control

(2011) Patrick L. Sheets et al.   JOURNAL OF NEUROPHYSIOLOGY

TRIP8b Regulates HCN1 Channel Trafficking and Gating through Two Distinct C-Terminal Interaction Sites

(2011) B. Santoro et al.   JOURNAL OF NEUROSCIENCE

Rapid Loss of Dendritic HCN Channel Expression in Hippocampal Pyramidal Neurons following Status Epilepticus

(2011) S. Jung et al.   JOURNAL OF NEUROSCIENCE

Recessive Loss-of-Function Mutation in the Pacemaker HCN2 Channel Causing Increased Neuronal Excitability in a Patient with Idiopathic Generalized Epilepsy

(2011) J. C. DiFrancesco et al.   JOURNAL OF NEUROSCIENCE

Presynaptic HCN1 channels regulate CaV3.2 activity and neurotransmission at select cortical synapses

(2011) Zhuo Huang et al.   NATURE NEUROSCIENCE

TRIP8b Splice Forms Act in Concert to Regulate the Localization and Expression of HCN1 Channels in CA1 Pyramidal Neurons

(2011) Rebecca Piskorowski et al.   NEURON

Ih-mediated depolarization enhances the temporal precision of neuronal integration

(2011) Ivan Pavlov et al.   Nature Communications

Increased seizure severity and seizure-related death in mice lacking HCN1 channels

(2010) Bina Santoro et al.   EPILEPSIA

Selective Participation of Somatodendritic HCN Channels in Inhibitory But Not Excitatory Synaptic Integration in Neurons of the Subthalamic Nucleus

(2010) J. F. Atherton et al.   JOURNAL OF NEUROSCIENCE

Downregulation of Dendritic HCN Channel Gating in Epilepsy Is Mediated by Altered Phosphorylation Signaling

(2010) S. Jung et al.   JOURNAL OF NEUROSCIENCE

HCN channels in behavior and neurological disease: Too hyper or not active enough?

(2010) Alan S. Lewis et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Dendritic ion channel trafficking and plasticity

(2010) Mala M. Shah et al.   TRENDS IN NEUROSCIENCES

Hyperpolarization-activated cation currents in human epileptogenic neocortex

(2009) Stephan Wierschke et al.   EPILEPSIA

Loss of Dendritic HCN1 Subunits Enhances Cortical Excitability and Epileptogenesis

(2009) Z. Huang et al.   JOURNAL OF NEUROSCIENCE

Complementary Theta Resonance Filtering by Two Spatially Segregated Mechanisms in CA1 Hippocampal Pyramidal Neurons

(2009) H. Hu et al.   JOURNAL OF NEUROSCIENCE

Alternatively Spliced Isoforms of TRIP8b Differentially Control h Channel Trafficking and Function

(2009) A. S. Lewis et al.   JOURNAL OF NEUROSCIENCE

HCN hyperpolarization-activated cation channels inhibit EPSPs by interactions with M-type K+ channels

(2009) Meena S George et al.   NATURE NEUROSCIENCE

Association with the Auxiliary Subunit PEX5R/Trip8b Controls Responsiveness of HCN Channels to cAMP and Adrenergic Stimulation

(2009) Gerd Zolles et al.   NEURON

TRIP8b Splice Variants Form a Family of Auxiliary Subunits that Regulate Gating and Trafficking of HCN Channels in the Brain

(2009) Bina Santoro et al.   NEURON

Hyperpolarization-Activated Cation Channels: From Genes to Function

(2009) Martin Biel et al.   PHYSIOLOGICAL REVIEWS

Variability in the subcellular distribution of ion channels increases neuronal diversity

(2009) Zoltan Nusser   TRENDS IN NEUROSCIENCES

HCN channels: Structure, cellular regulation and physiological function

(2008) C. Wahl-Schott et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The h Channel Mediates Location Dependence and Plasticity of Intrinsic Phase Response in Rat Hippocampal Neurons

(2008) R. Narayanan et al.   JOURNAL OF NEUROSCIENCE

Downregulation of Dendritic Ih in CA1 Pyramidal Neurons after LTP

(2008) E. Campanac et al.   JOURNAL OF NEUROSCIENCE

Mislocalization of h channel subunits underlies h channelopathy in temporal lobe epilepsy

(2008) Minyoung Shin et al.   NEUROBIOLOGY OF DISEASE

h channel-dependent deficit of theta oscillation resonance and phase shift in temporal lobe epilepsy

(2008) Béatrice Marcelin et al.   NEUROBIOLOGY OF DISEASE

Active dendrites: colorful wings of the mysterious butterflies

(2008) Daniel Johnston et al.   TRENDS IN NEUROSCIENCES

Upregulated H-Current in hyperexcitable CA1 dendrites after febrile seizures

(2008) Jonas Dyhrfjeld-Johnsen   Frontiers in Cellular Neuroscience