Immune Impairment Associated with Vitamin A Deficiency: Insights from Clinical Studies and Animal Model Research

Gut commensals expand vitamin A metabolic capacity of the mammalian host

(2022) Maryam Bonakdar et al.   Cell Host & Microbe

Gut Microbiota and Development of Vibrio cholerae-Specific Long-Term Memory B Cells in Adults after Whole-Cell Killed Oral Cholera Vaccine

(2021) Denise Chac et al.   INFECTION AND IMMUNITY

The role of micronutrient and immunomodulation effect in the vaccine era of COVID-19

(2021) Yu-Ju Lai et al.   Journal of the Chinese Medical Association

Links between fecal microbiota and the response to vaccination against influenza A virus in pigs

(2021) Marion Borey et al.   npj Vaccines

Enteric virome negatively affects seroconversion following oral rotavirus vaccination in a longitudinally sampled cohort of Ghanaian infants

(2021) Andrew HyoungJin Kim et al.   Cell Host & Microbe

Impact of maternal antibodies and microbiota development on the immunogenicity of oral rotavirus vaccine in African, Indian, and European infants

(2021) Edward P. K. Parker et al.   Nature Communications

Vitamin A Deficiency Exacerbates Gut Microbiota Dysbiosis and Cognitive Deficits in Amyloid Precursor Protein/Presenilin 1 Transgenic Mice

(2021) Bo-Wen Chen et al.   Frontiers in Aging Neuroscience

Improving Chicken Responses to Glycoconjugate Vaccination Against Campylobacter jejuni

(2021) Harald Nothaft et al.   Frontiers in Microbiology

A Review of Micronutrients and the Immune System–Working in Harmony to Reduce the Risk of Infection

(2020) Adrian F. Gombart et al.   Nutrients

Vitamin A supplement after neonatal Streptococcus pneumoniae pneumonia inhibits the progression of experimental asthma by altering CD4+T cell subsets

(2020) Yonglu Tian et al.   Scientific Reports

Vitamin A deficiency is associated with severe Mycoplasma pneumoniae pneumonia in children

(2020) Yan Xing et al.   Annals of Translational Medicine

Retinoic Acid Modulates Hyperactive T Cell Responses and Protects Vitamin A–Deficient Mice against Persistent Lymphocytic Choriomeningitis Virus Infection

(2020) Yuejin Liang et al.   JOURNAL OF IMMUNOLOGY

Micronutrients as immunomodulatory tools for COVID-19 management

(2020) Amin Gasmi et al.   CLINICAL IMMUNOLOGY

Consequences of Vitamin A Deficiency: Immunoglobulin Dysregulation, Squamous Cell Metaplasia, Infectious Disease, and Death

(2020) Sherri L. Surman et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Vitamin A Corrects Tissue Deficits in Diet‐Induced Obese Mice and Reduces Influenza Infection After Vaccination and Challenge

(2020) Rhiannon R. Penkert et al.   Obesity

Impaired Hepatic Vitamin A Metabolism in NAFLD Mice Leading to Vitamin A Accumulation in Hepatocytes

(2020) Ali Saeed et al.   Cellular and Molecular Gastroenterology and Hepatology

Vitamin A deficiency dysregulates immune responses toward influenza virus and increases mortality after bacterial coinfections

(2020) Rhiannon R Penkert et al.   JOURNAL OF INFECTIOUS DISEASES

Vitamin A Deficiency in the Early-Life Periods Alters a Diversity of the Colonic Mucosal Microbiota in Rats

(2020) Baolin Chen et al.   Frontiers in Nutrition

The impact of the microbiota-gut-brain axis on Alzheimer’s disease pathophysiology

(2020) Tejaswini Doifode et al.   PHARMACOLOGICAL RESEARCH

Retinoic Acid Receptor Alpha Represses a Th9 Transcriptional and Epigenomic Program to Reduce Allergic Pathology

(2019) Daniella M. Schwartz et al.   IMMUNITY

Gut microbiome and cancer immunotherapy

(2019) Weina Li et al.   CANCER LETTERS

Neonatal Vitamin A Supplementation and Vitamin A Status Are Associated with Gut Microbiome Composition in Bangladeshi Infants in Early Infancy and at 2 Years of Age

(2019) M Nazmul Huda et al.   JOURNAL OF NUTRITION

Influences of Vitamin A on Vaccine Immunogenicity and Efficacy

(2019) Rhiannon R. Penkert et al.   Frontiers in Immunology

Vitamin A deficiency impairs the immune response to intranasal vaccination and RSV infection in neonatal calves

(2019) Jodi L. McGill et al.   Scientific Reports

Composition of gut microbiota and its influence on the immunogenicity of oral rotavirus vaccines

(2018) Cliff A. Magwira et al.   VACCINE

Association of Nutritional Status with the Response to Infection with Leishmania chagasi

(2018) Bruna L. Lima Maciel et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Vitamin A Deficiency and Clinical Disease: An Historical Overview

(2018) Alfred Sommer   JOURNAL OF NUTRITION

Impact of Retinoic Acid on Immune Cells and Inflammatory Diseases

(2018) Luana de Mendonça Oliveira et al.   MEDIATORS OF INFLAMMATION

Vitamin A Deficiency and the Lung

(2018) Joaquín Timoneda et al.   Nutrients

Modulation of Intestinal Immune and Barrier Functions by Vitamin A: Implications for Current Understanding of Malnutrition and Enteric Infections in Children

(2018) Pedro de Medeiros et al.   Nutrients

Role of Vitamin A in the Immune System

(2018) Zhiyi Huang et al.   Journal of Clinical Medicine

Commensals Suppress Intestinal Epithelial Cell Retinoic Acid Synthesis to Regulate Interleukin-22 Activity and Prevent Microbial Dysbiosis

(2018) Mayara Grizotte-Lake et al.   IMMUNITY

Neonatal vitamin A supplementation and immune responses to oral polio vaccine in Zimbabwean infants

(2018) James A Church et al.   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE

Immune Function and Micronutrient Requirements Change over the Life Course

(2018) Silvia Maggini et al.   Nutrients

Vitamins and Minerals in Inflammatory Bowel Disease

(2017) Fayez K. Ghishan et al.   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

Vitamin A and D Deficiencies Associated With Incident Tuberculosis in HIV-Infected Patients Initiating Antiretroviral Therapy in Multinational Case-Cohort Study

(2017) Mark W. Tenforde et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

IL-22 Increases Permeability of Intestinal Epithelial Tight Junctions by Enhancing Claudin-2 Expression

(2017) Yaya Wang et al.   JOURNAL OF IMMUNOLOGY

Low Retinol-Binding Protein and Vitamin D Levels Are Associated with Severe Outcomes in Children Hospitalized with Lower Respiratory Tract Infection and Respiratory Syncytial Virus or Human Metapneumovirus Detection

(2017) Julia L. Hurwitz et al.   JOURNAL OF PEDIATRICS

The effects of micronutrient deficiencies on bacterial species from the human gut microbiota

(2017) Matthew C. Hibberd et al.   Science Translational Medicine

Disturbed Vitamin A Metabolism in Non-Alcoholic Fatty Liver Disease (NAFLD)

(2017) Ali Saeed et al.   Nutrients

New insights and changing paradigms in the regulation of vitamin A metabolism in development

(2017) Stephen R. Shannon et al.   Wiley Interdisciplinary Reviews-Developmental Biology

All-Trans Retinoic Acid Promotes an M1- to M2-Phenotype Shift and Inhibits Macrophage-Mediated Immunity to Leishmania major

(2017) Natália S. Vellozo et al.   Frontiers in Immunology

Vitamin Supplementation at the Time of Immunization with a Cold-Adapted Influenza Virus Vaccine Corrects Poor Mucosal Antibody Responses in Mice Deficient for Vitamins A and D

(2016) S. L. Surman et al.   Clinical and Vaccine Immunology

The vicious cycle of vitamin a deficiency: A review

(2016) Elina Manusevich Wiseman et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Metabolites: messengers between the microbiota and the immune system

(2016) Maayan Levy et al.   GENES & DEVELOPMENT

Effect of vitamin A and Zn supplementation on indices of vitamin A status, haemoglobin level and defecation of children with persistent diarrhea

(2016) Yuting Wang et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Significant Correlation Between the Infant Gut Microbiome and Rotavirus Vaccine Response in Rural Ghana

(2016) Vanessa C. Harris et al.   JOURNAL OF INFECTIOUS DISEASES

Maternal vitamin A deficiency during pregnancy affects vascularized islet development

(2016) Chiao-Yun Chien et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The microbiota in adaptive immune homeostasis and disease

(2016) Kenya Honda et al.   NATURE

Hepatic Retinyl Ester Hydrolases and the Mobilization of Retinyl Ester Stores

(2016) Lukas Grumet et al.   Nutrients

Retinoic Acid as a Modulator of T Cell Immunity

(2016) Maria Bono et al.   Nutrients

Antiviral effect of vitamin A on norovirus infection via modulation of the gut microbiome

(2016) Heetae Lee et al.   Scientific Reports

Tight Junction Disruption Induced by Type 3 Secretion System Effectors Injected by Enteropathogenic and Enterohemorrhagic Escherichia coli

(2016) Paul Ugalde-Silva et al.   Frontiers in Cellular and Infection Microbiology

The effects of vitamin A supplementation with measles vaccine on leucocyte counts and in vitro cytokine production

(2015) Kristoffer Jarlov Jensen et al.   BRITISH JOURNAL OF NUTRITION

Gut-Microbiota-Brain Axis and Its Effect on Neuropsychiatric Disorders With Suspected Immune Dysregulation

(2015) Anastasia I. Petra et al.   CLINICAL THERAPEUTICS

Vitamin A-Deficient Hosts Become Nonsymptomatic Reservoirs of Escherichia coli-Like Enteric Infections

(2015) Kaitlin L. McDaniel et al.   INFECTION AND IMMUNITY

Vitamin A deficient mice exhibit increased viral antigens and enhanced cytokine/chemokine production in nasal tissues following respiratory virus infection despite the presence of FoxP3+T cells

(2015) Rhiannon R. Penkert et al.   INTERNATIONAL IMMUNOLOGY

Antiviral effects of Lactobacillus ruminis SPM0211 and Bifidobacterium longum SPM1205 and SPM1206 on rotavirus-infected Caco-2 cells and a neonatal mouse model

(2015) Joo Yeon Kang et al.   JOURNAL OF MICROBIOLOGY

Consecutive oral administration ofBifidobacterium longumMM-2 improves the defense system against influenza virus infection by enhancing natural killer cell activity in a murine model

(2015) Tomohiro Kawahara et al.   MICROBIOLOGY AND IMMUNOLOGY

Potential for use of retinoic acid as an oral vaccine adjuvant

(2015) M. Mwanza-Lisulo et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Vitamin A Deficiency Impairs Mucin Expression and Suppresses the Mucosal Immune Function of the Respiratory Tract in Chicks

(2015) Xiaoxiao Fan et al.   PLoS One

Microbiota and bile acid profiles in retinoic acid-primed mice that exhibit accelerated liver regeneration

(2015) Hui-Xin Liu et al.   Oncotarget

Trends and mortality effects of vitamin A deficiency in children in 138 low-income and middle-income countries between 1991 and 2013: a pooled analysis of population-based surveys

(2015) Gretchen A Stevens et al.   Lancet Global Health

Intranasal Administration of Retinyl Palmitate with a Respiratory Virus Vaccine Corrects Impaired Mucosal IgA Response in the Vitamin A-Deficient Host

(2014) Sherri L. Surman et al.   Clinical and Vaccine Immunology

Immunomodulation in Patients with Chronic Hand Eczema Treated with Oral Alitretinoin

(2014) Mandana Schindler et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Unanticipated Mycobacterium tuberculosis complex culture inhibition by immune modulators, immune suppressants, a growth enhancer, and vitamins A and D: clinical implications

(2014) Robert J. Greenstein et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Vitamin A Deficiency Is Associated with Gastrointestinal and Respiratory Morbidity in School-Age Children1–3

(2014) Kathryn A. Thornton et al.   JOURNAL OF NUTRITION

Oral Doses of α-Retinyl Ester Track Chylomicron Uptake and Distribution of Vitamin A in a Male Piglet Model for Newborn Infants

(2014) Napaporn Riabroy et al.   JOURNAL OF NUTRITION

Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity

(2014) Serge A. van de Pavert et al.   NATURE

Stool Microbiota and Vaccine Responses of Infants

(2014) M. N. Huda et al.   PEDIATRICS

Adaptation of Innate Lymphoid Cells to a Micronutrient Deficiency Promotes Type 2 Barrier Immunity

(2014) S. P. Spencer et al.   SCIENCE

Oral retinyl palmitate or retinoic acid corrects mucosal IgA responses toward an intranasal influenza virus vaccine in vitamin A deficient mice

(2014) S.L. Surman et al.   VACCINE

Prenatal vitamin A deficiency impairs adaptive immune responses to pentavalent rotavirus vaccine (RotaTeq®) in a neonatal gnotobiotic pig model

(2014) Sukumar Kandasamy et al.   VACCINE

Oral administration of Lactobacillus gasseri SBT2055 is effective for preventing influenza in mice

(2014) Yosuke Nakayama et al.   Scientific Reports

Soil-Transmitted Helminth Infection and Nutritional Status Among Urban Slum Children in Kenya

(2013) Parminder S. Suchdev et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Prenatally Acquired Vitamin A Deficiency Alters Innate Immune Responses to Human Rotavirus in a Gnotobiotic Pig Model

(2013) A. N. Vlasova et al.   JOURNAL OF IMMUNOLOGY

Divergent Immunomodulating Effects of Probiotics on T Cell Responses to Oral Attenuated Human Rotavirus Vaccine and Virulent Human Rotavirus Infection in a Neonatal Gnotobiotic Piglet Disease Model

(2013) K. S. Chattha et al.   JOURNAL OF IMMUNOLOGY

Differential role of all-trans retinoic acid in promoting the development of CD4+ and CD8+ regulatory T cells

(2013) Jilin Ma et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

(2013) Gijs den Besten et al.   JOURNAL OF LIPID RESEARCH

Impact of Oral Typhoid Vaccination on the Human Gut Microbiota and Correlations with S. Typhi-Specific Immunological Responses

(2013) Emiley A. Eloe-Fadrosh et al.   PLoS One

Vitamin A Deficiency Impairs Adaptive B and T Cell Responses to a Prototype Monovalent Attenuated Human Rotavirus Vaccine and Virulent Human Rotavirus Challenge in a Gnotobiotic Piglet Model

(2013) Kuldeep S. Chattha et al.   PLoS One

Probiotics and colostrum/milk differentially affect neonatal humoral immune responses to oral rotavirus vaccine

(2013) Kuldeep S. Chattha et al.   VACCINE

Serum cytokines associated with severity and complications of kala-azar

(2013) Dorcas L Costa et al.   Pathogens and Global Health

Microbiota of De-Novo Pediatric IBD: Increased Faecalibacterium Prausnitzii and Reduced Bacterial Diversity in Crohn's But Not in Ulcerative Colitis

(2012) Richard Hansen et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Hypovitaminosis A coupled to secondary bacterial infection in beef cattle

(2012) Xiuyuan He et al.   BMC Veterinary Research

Intestinal Commensal Microbes as Immune Modulators

(2012) Ivaylo I. Ivanov et al.   Cell Host & Microbe

Reduced Frequencies and Heightened CD103 Expression among Virus-Induced CD8+T Cells in the Respiratory Tract Airways of Vitamin A-Deficient Mice

(2012) Rajeev Rudraraju et al.   Clinical and Vaccine Immunology

Role of Defensins and Cathelicidin LL37 in Auto-Immune and Auto- Inflammatory Diseases

(2012) Loredana Frasca et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Intestinal Microbes Affect Phenotypes and Functions of Invariant Natural Killer T Cells in Mice

(2012) Gerhard Wingender et al.   GASTROENTEROLOGY

Vitamin A deficiency is associated with hepatitis C virus chronic infection and with unresponsiveness to interferon-based antiviral therapy

(2012) Davide Bitetto et al.   HEPATOLOGY

Effect of maternal vitamin A deficiency during pregnancy on neonatal kidney size

(2012) Ehab K. El-Khashab et al.   JOURNAL OF PERINATAL MEDICINE

Retinoic acid regulates the development of a gut-homing precursor for intestinal dendritic cells

(2012) R Zeng et al.   Mucosal Immunology

Retinoic acid signalling in gastrointestinal parasite infections: lessons from mouse models

(2012) R. J. M. HURST et al.   PARASITE IMMUNOLOGY

The influence of diet on the gut microbiota

(2012) Karen P. Scott et al.   PHARMACOLOGICAL RESEARCH

Effect of vitamin A deficiency on the immune response in obesity

(2012) Olga P. García   PROCEEDINGS OF THE NUTRITION SOCIETY

Vitamin A Deficiency Disrupts Vaccine-Induced Antibody-Forming Cells and the Balance of IgA/IgG Isotypes in the Upper and Lower Respiratory Tract

(2012) Sherri L. Surman et al.   VIRAL IMMUNOLOGY

Influence of Microbiota on Viral Infections

(2012) Jessica Wilks et al.   PLoS Pathogens

Vitamin A deficiency in patients with hepatitis C virus-related chronic liver disease

(2011) W. A. F. Peres et al.   BRITISH JOURNAL OF NUTRITION

Essential Role for Retinoic Acid in the Promotion of CD4+ T Cell Effector Responses via Retinoic Acid Receptor Alpha

(2011) Jason A. Hall et al.   IMMUNITY

The Role of Retinoic Acid in Tolerance and Immunity

(2011) Jason A. Hall et al.   IMMUNITY

Retinoic acid induces homing of protective T and B cells to the gut after subcutaneous immunization in mice

(2011) Swantje I. Hammerschmidt et al.   JOURNAL OF CLINICAL INVESTIGATION

Vitamin A Deficiency Impairs Vaccine-Elicited Gastrointestinal Immunity

(2011) D. R. Kaufman et al.   JOURNAL OF IMMUNOLOGY

Host Immunity and Pathogen Strain Contribute to Intestinal Disaccharidase Impairment following Gut Infection

(2011) S. Solaymani-Mohammadi et al.   JOURNAL OF IMMUNOLOGY

Vitamin A Modifies the Intestinal Chemokine and Cytokine Responses to Norovirus Infection in Mexican Children

(2011) Kurt Z. Long et al.   JOURNAL OF NUTRITION

The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication

(2011) P. Bercik et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

(2011) J. A. Bravo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Toll-Like Receptor 2 Pathway Establishes Colonization by a Commensal of the Human Microbiota

(2011) J. L. Round et al.   SCIENCE

Innate or Adaptive Immunity? The Example of Natural Killer Cells

(2011) E. Vivier et al.   SCIENCE

Vitamin A in Reproduction and Development

(2011) Margaret Clagett-Dame et al.   Nutrients

Gut microbiome-host interactions in health and disease

(2011) James M Kinross et al.   Genome Medicine

Giardia lamblia Infection and Its Implications for Vitamin A Liver Stores in School Children

(2010) Humberto Astiazaran-Garcia et al.   ANNALS OF NUTRITION AND METABOLISM

Antioxidant nutrient intakes and corresponding biomarkers associated with the risk of atopic dermatitis in young children

(2010) S-Y Oh et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Uptake of all-transretinoic acid–containing aerosol by inhalation to lungs in a guinea pig model system—A pilot study

(2010) Michael W. Schäffer et al.   EXPERIMENTAL LUNG RESEARCH

Downregulation of Th17 Cells in the Small Intestine by Disruption of Gut Flora in the Absence of Retinoic Acid

(2010) H.-R. Cha et al.   JOURNAL OF IMMUNOLOGY

Effects of Vitamin A Supplementation on Intestinal Barrier Function, Growth, Total Parasitic, and Specific Giardia spp Infections in Brazilian Children: A Prospective Randomized, Double-blind, Placebo-controlled Trial

(2010) Aldo AM Lima et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

All-trans retinoic acid for treatment of chronic hepatitis C

(2010) Wulf O. Böcher et al.   LIVER INTERNATIONAL

Effects of vitamin A deficiency on mucosal immunity and response to intestinal infection in rats

(2010) Yi Yang et al.   NUTRITION

The Role of Vitamin A and Related Retinoids in Immune Function

(2010) Richard D. Semba   NUTRITION REVIEWS

Effects of IL-13 on Mucociliary Differentiation of Pediatric Asthmatic Bronchial Epithelial Cells

(2010) Surendran Thavagnanam et al.   PEDIATRIC RESEARCH

Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota

(2010) J. L. Round et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High and Low Vitamin A Therapies Induce Distinct FoxP3+ T-Cell Subsets and Effectively Control Intestinal Inflammation

(2009) Seung G. Kang et al.   GASTROENTEROLOGY

The Key Role of Segmented Filamentous Bacteria in the Coordinated Maturation of Gut Helper T Cell Responses

(2009) Valérie Gaboriau-Routhiau et al.   IMMUNITY

Eukaryotic-Microbiota Crosstalk: Potential Mechanisms for Health Benefits of Prebiotics and Probiotics

(2008) Norman G. Hord   Annual Review of Nutrition

Markers of Innate Immune Function Are Associated with Vitamin A Stores in Men

(2008) Shaikh M. Ahmad et al.   JOURNAL OF NUTRITION

Bacterial population and innate immunity-related genes in rat gastrointestinal tract are altered by vitamin A-deficient diet

(2008) Einat Amit-Romach et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis

(2008) Djahida Bouskra et al.   NATURE

Retinoic acid production by intestinal dendritic cells and its role in T-cell trafficking

(2008) Makoto Iwata   SEMINARS IN IMMUNOLOGY

Effect of Cryptosporidium parvum infection on the absorptive capacity and paracellular permeability of the small intestine in neonatal calves

(2007) Pavel Klein et al.   VETERINARY PARASITOLOGY