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Cell Biology
Gui Qian, Yihua Zhang, Yinan Liu, Manman Li, Bowen Xin, Wenyi Jiang, Wendong Han, Yu Wang, Xian Tang, Liuyan Li, Lingyan Zhu, Tao Sun, Bo Yan, Yongtang Zheng, Jianqing Xu, Baoxue Ge, Zheng Zhang, Dapeng Yan
Summary: Cyclic GMP-AMP synthase (cGAS) recognizes Y-form cDNA of HIV-1 and initiates antiviral immune response, but the p6 protein of HIV-1 suppresses IFN-I expression and promotes immune evasion. Glutamylated p6 inhibits STING interaction with TRIM32 or AMFR, suppressing STING activation by inhibiting K27 and K63 polyubiquitination at K337. CoCl2, a CCP agonist, counteracts p6 glutamylation and inhibits HIV-1 immune evasion.
Review
Immunology
Xinyu Lu, Qianhui Chen, Hongyan Liu, Xiaoyong Zhang
Summary: The non-canonical NF-kappa B signaling pathway is crucial in HBV infection, influencing host immune responses, viral replication, and liver damage. Understanding the interaction between HBV and this pathway may lead to the discovery of potential therapeutic targets and drugs for treating HBV infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Tong Feng, Qiao-feng Wu
Summary: This review discusses the role of NF-κB in the pathogenesis of osteoarthritis and how ncRNAs participate in and affect the incidence and progression of OA, offering novel potential therapeutic options for OA treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Microbiology
Joshua B. Reus, Emily A. Rex, Don B. Gammon
Summary: The nuclear factor-kappa B (NF-kappa B) family of transcription factors plays a regulatory role in host inflammatory and antiviral gene expression during viral infection. However, viruses have developed strategies to manipulate and inhibit NF-kappa B signaling. Vaccinia virus (VV) encodes multiple inhibitors of NF-kappa B signaling and these inhibitors affect VV virulence in animal models. This review focuses on the mechanisms through which VV-encoded antagonists inhibit NF-kappa B pathway activation and signaling.
Article
Immunology
Shuxia Wang, Yongli Gao
Summary: The study revealed that miR-155-5p from Pancreatic cancer (PC)-derived EVs promotes immune evasion in PC by suppressing EHF and activating NF-kappa B signaling. miR-155-5p was found to be upregulated in PC tissue samples and cell lines, with knockdown enhancing anti-tumor immunity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Zhaohai Wen, Yue Zhang, Jiajun Feng, Kalibixiati Aimulajiang, Muhammad Tahir Aleem, Mingmin Lu, Lixin Xu, Xiaokai Song, Xiangrui Li, Ruofeng Yan
Summary: This study found that HcESPs inhibit the adaptive immune response of goats through various mechanisms, helping H. contortus evade immunity. Furthermore, HcESPs reverse the LPS-induced immune inflammatory response. The findings contribute to a better understanding of the evasion mechanisms of H. contortus and provide a new approach for preventing infection by this parasite.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Karolina Nowak, Ewa Jablonska, Wioletta Ratajczak-Wrona
Summary: This review focuses on the effects of xenoestrogens (XEs) on the NF-kappa B signaling pathway in immune cells. The findings suggest that XEs generally activate NF-kappa B and play a crucial role in the development and functioning of the immune system.
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Microbiology
Matteo Bulati, Rosalia Busa, Claudia Carcione, Gioacchin Iannolo, Giuseppina Di Mento, Nicola Cuscino, Roberto Di Gesu, Antonio Palumbo Piccionello, Silvestre Buscemi, Anna Paola Carreca, Floriana Barbera, Francesco Monaco, Francesca Cardinale, Pier Giulio Conaldi, Bruno Douradinha
Summary: Multidrug resistant Klebsiella pneumoniae with LPS O2afg serotypes are able to evade the initial inflammatory immune response and systematically spread inside the host, resulting in various pathologies associated with this bacterium.
Article
Medicine, Research & Experimental
Rui He, Yan He, Ran Du, Chenxin Liu, Zeran Chen, Anqi Zeng, Linjiang Song
Summary: Tumor-associated macrophages (TAMs) are crucial for tumor immune microenvironment as they both promote tumor growth and anti-tumor immunity. Regulating TAMs through the NF-κB pathway has shown potential in improving tumor immune microenvironment. Despite controversies and the idea of combining therapies in this field, this article reviews the progress in immunotherapy aiming to improve tumor immune microenvironment through mechanisms that regulate TAMs (including promoting M1 polarization, inhibiting M2 polarization, and regulating TAMs infiltration).
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Environmental Sciences
Peng Tian Li, Ying Li, Ying Chen, Jia Xi Zhang, Zi Hao Luo, Yi Fan Zhang, Jing Jiang, Yi Lei Wang, Zi Ping Zhang, Yong Hua Jiang, Peng Fei Zou
Summary: A protein called Lc-TRAF7 was discovered in the large yellow croaker, which is widely expressed in healthy fish and can be induced by various stimuli. Lc-TRAF7 plays a role in the host's antiviral response by regulating the NF-kappa B and IRF3/7 signaling pathways.
FRONTIERS IN MARINE SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Pengfei Shi, Jie Xu, Hongjuan Cui
Summary: This article summarizes the pathogenesis of glioblastoma multiforme (GBM) and the therapeutic methods related to NF-κB signaling, aiming to improve the survival rate of patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Microbiology
Yunqiang Chen, Yuheng Shi, Jing Wu, Nan Qi
Summary: MAVS functions as a crucial switch in immune signal transduction against RNA viruses, forming aggregates upon viral infection to activate interferon signaling and maintain immune homeostasis. Viruses and hosts target MAVS for regulation, with researchers focusing on post-translational modifications like ubiquitination and phosphorylation.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Yongcan Zhou, Xiaojuan Chen, Zhenjie Cao, Jianlong Li, Hao Long, Ying Wu, Zhengshi Zhang, Yun Sun
Summary: R848 stimulates lymphocyte proliferation and survival in fish, inhibits bacterial replication, enhances antibacterial immunity through the TLR7/8-Myd88-NF-κB signaling pathway, but is affected by CQ and Pepinh-MYD.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Microbiology
Xiu-Zhong Zhang, Fu-Huang Li, Xiao-Jia Wang
Summary: TRIM proteins play crucial roles in modulating antiviral immune responses, but viruses can evade host immune responses by antagonizing or utilizing TRIMs.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Fisheries
Yeojin Hong, Jiae Lee, Thi Hao Vu, Sooyeon Lee, Hyun S. Lillehoj, Yeong Ho Hong
Summary: This study demonstrates the immunoregulatory functions of LPS-activated exosomes in chicken immune systems, enhancing gene expression of cytokines and chemokines and inducing the MyD88/NF-kappa B signaling pathway to regulate immune responses. In the future, LPS-stimulated exosomes may be utilized as an immune stimulator.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Oncology
Jiyu Guan, Dan Huang, Konstantin Yakimchuk, Sam Okret
MOLECULAR CANCER THERAPEUTICS
(2018)
Article
Developmental Biology
Fei Gao, Jiyu Guan, Limei Liu, Sheng Zhang, Peipei An, Anran Fan, Guangqi Song, Peng Zhang, Tianchuang Zhao, Bo Tang, Xueming Zhang, Ziyi Li
Article
Genetics & Heredity
Jiawei Zhong, Jiyu Guan, Yanlong Zhou, Shanshan Cui, Zhenzhen Wang, Shuaishuai Zhou, Mengshi Xu, Xinyu Wei, Yu Gao, Shaohua Zhai, Deguang Song, Wenqi He, Feng Gao, Kui Zhao
Article
Microbiology
Yanlong Zhou, Feng Gao, Lijun Lv, Shuai Wang, Wenqi He, Yungang Lan, Zi Li, Huijun Lu, Deguang Song, Jiyu Guan, Kui Zhao
Summary: The study demonstrates that CypB plays a critical role in ORFV replication by interacting with the ORF058 protein, providing new insights into the pathogenesis of ORFV.
VETERINARY MICROBIOLOGY
(2021)
Article
Genetics & Heredity
Yanlong Zhou, Jiyu Guan, Lijun Lv, Huan Cui, Mengshi Xu, Shuai Wang, Zhaohui Yu, Ruixue Zhen, Shishi He, Ziyu Fang, Jiawei Zhong, Shanshan Cui, Shiying Yu, Deguang Song, Wenqi He, Feng Gao, Kui Zhao
Summary: This study reported the complete genomic sequences of ORFV-GZ18 and ORFV-CL18, which could be useful for investigating the host range, geographic distribution, and genetic evolution of the virus in Southern West and Northern East China.
Article
Immunology
Yan Wang, Kui Zhao, Deguang Song, Le Du, Xinyue Wang, Feng Gao, Huijun Lu, Jiyu Guan
Summary: This study constructed a new DNA vaccine candidate for Orf virus and demonstrated that the vaccine induced stronger humoral and cellular immune responses, suggesting its potential advantages in preventing Orf virus infection.
Article
Biochemistry & Molecular Biology
Jing Lin, Fei Liu, Fei Gao, Yujia Chen, Renling Wang, Xinyue Wang, Yue Li, Qi Li, Shihui Sun, Zi Li, Yungang Lan, Huijun Lu, Wei Guo, Li Du, Feng Gao, Deguang Song, Kui Zhao, Jiyu Guan, Wenqi He
Summary: This study discovers that oncolytic viruses can induce tumor cell pyroptosis through activating GSDME, which enhances the efficacy of immunotherapy and makes immunologically "cold" tumors more sensitive to checkpoint blockade.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Microbiology
Huan Cui, Kui Zhao, Cheng Zhang, Jing Lin, Shihui Sun, Qi Li, Le Du, Chunmao Zhang, Juxiang Liu, Feng Gao, Wenqi He, Yuwei Gao, Zhendong Guo, Jiyu Guan
Summary: In this study, it was found that iORFV can reduce the proportion of exhaled small particle aerosols and significantly decrease the concentration of SARS-CoV-2 RNA-containing aerosol particles in the early stages after viral inoculation. Moreover, iORFV completely clears smaller aerosol particles carrying infectious viruses and blocks viral noncontact transmission.
FRONTIERS IN MICROBIOLOGY
(2022)