Co-Infection of the Epstein–Barr Virus and the Kaposi Sarcoma-Associated Herpesvirus

Clinical Characteristics and Survival Outcomes of Primary Effusion Lymphoma: A National Cancer Database Study

(2022) Firas Baidoun et al.   Clinical Lymphoma Myeloma & Leukemia

Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis

(2022) Kjetil Bjornevik et al.   SCIENCE

A bivalent Epstein-Barr virus vaccine induces neutralizing antibodies that block infection and confer immunity in humanized mice

(2022) Chih-Jen Wei et al.   Science Translational Medicine

HHV-8 associated lymphoma

(2022) Eric Oksenhendler et al.   CURRENT OPINION IN ONCOLOGY

Concomitant Cytotoxic Effector Differentiation of CD4+ and CD8+ T Cells in Response to EBV-Infected B Cells

(2022) Yumi Tamura et al.   Cancers

KSHV (HHV8) vaccine: promises and potential pitfalls for a new anti-cancer vaccine

(2022) Corey Casper et al.   npj Vaccines

Pomalidomide restores immune recognition of primary effusion lymphoma through upregulation of ICAM-1 and B7-2

(2021) Prabha Shrestha et al.   PLoS Pathogens

KSHV infection drives poorly cytotoxic CD56-negative natural killer cell differentiation in vivo upon KSHV/EBV dual infection

(2021) Nicole Caduff et al.   Cell Reports

The Role of Lytic Infection for Lymphomagenesis of Human γ-Herpesviruses

(2021) Christian Münz   Frontiers in Cellular and Infection Microbiology

KSHV/HHV8-mediated hematologic diseases

(2021) Ethel Cesarman et al.   BLOOD

Activation and Evasion of Innate Immunity by Gammaherpesviruses

(2021) Philip T. Lange et al.   JOURNAL OF MOLECULAR BIOLOGY

Viral and immunological markers of HIV-associated Kaposi sarcoma recurrence

(2021) Owen Ngalamika et al.   PLoS One

How Epstein–Barr Virus and Kaposi’s Sarcoma-Associated Herpesvirus Are Maintained Together to Transform the Same B-Cell

(2021) Arthur U. Sugden et al.   Viruses-Basel

NK cells eliminate Epstein-Barr virus bound to B cells through a specific antibody-mediated uptake

(2021) Elisenda Alari-Pahissa et al.   PLoS Pathogens

Estimating the global burden of Epstein–Barr virus-related cancers

(2021) Yide Wong et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Compartmentalized T cell profile in the lungs of patients with HIV-1-associated pulmonary Kaposi sarcoma

(2021) Tarisiro Matiza et al.   MEDICINE

Kaposi’s sarcoma-associated herpesvirus T cell responses in HIV seronegative individuals from rural Uganda

(2021) Angela Nalwoga et al.   Nature Communications

The regulation of KSHV lytic reactivation by viral and cellular factors

(2021) Praneet Kaur Sandhu et al.   Current Opinion in Virology

KSHV: Immune Modulation and Immunotherapy

(2020) Grant Broussard et al.   Frontiers in Immunology

Distinct genetic architectures and environmental factors associate with host response to the γ2-herpesvirus infections

(2020) Neneh Sallah et al.   Nature Communications

Co-infection of Cytomegalovirus and Epstein-Barr Virus Diminishes the Frequency of CD56dimNKG2A+KIR− NK Cells and Contributes to Suboptimal Control of EBV in Immunosuppressed Children With Post-transplant Lymphoproliferative Disorder

(2020) Janice K. P. Lam et al.   Frontiers in Immunology

Oncogenic Properties of the EBV ZEBRA Protein

(2020) Diego Germini et al.   Cancers

Kaposi’s Sarcoma-Associated Herpesvirus Drives a Super-Enhancer-Mediated Survival Gene Expression Program in Primary Effusion Lymphoma

(2020) Mark Manzano et al.   mBio

Quantitative Proteomics Analysis of Lytic KSHV Infection in Human Endothelial Cells Reveals Targets of Viral Immune Modulation

(2020) Ildar Gabaev et al.   Cell Reports

Defective Epstein–Barr virus in chronic active infection and haematological malignancy

(2019) Yusuke Okuno et al.   Nature Microbiology

Kaposi sarcoma

(2019) Ethel Cesarman et al.   Nature Reviews Disease Primers

Heterologous prime-boost vaccination protects against EBV antigen–expressing lymphomas

(2019) Julia Rühl et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanisms of B-cell oncogenesis induced by Epstein-Barr virus

(2019) Abhik Saha et al.   JOURNAL OF VIROLOGY

Infection and immune control of human oncogenic γ-herpesviruses in humanized mice

(2019) Donal McHugh et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

CCL5 promotes breast cancer recurrence through macrophage recruitment in residual tumors

(2019) Andrea Walens et al.   eLife

Epstein-Barr virus tegument protein BGLF2 inhibits NF-κB activity by preventing p65 Ser536 phosphorylation

(2019) Tao Chen et al.   FASEB JOURNAL

Mutual detection of Kaposi's sarcoma‐associated herpesvirus and Epstein–Barr virus in blood and saliva of Cameroonians with and without Kaposi's sarcoma

(2019) Nazzarena Labo et al.   INTERNATIONAL JOURNAL OF CANCER

Primary EBV Infection Induces an Acute Wave of Activated Antigen-Specific Cytotoxic CD4+ T Cells

(2019) Benjamin J. Meckiff et al.   JOURNAL OF IMMUNOLOGY

How Kaposi’s sarcoma-associated herpesvirus stably transforms peripheral B cells towards lymphomagenesis

(2019) Aurélia Faure et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A multivalent Kaposi sarcoma-associated herpesvirus-like particle vaccine capable of eliciting high titers of neutralizing antibodies in immunized rabbits

(2019) David H. Mulama et al.   VACCINE

Signaling pathways involved in the T‐cell‐mediated immunity against Epstein‐Barr virus: Lessons from genetic diseases

(2019) Sylvain Latour et al.   IMMUNOLOGICAL REVIEWS

Latency and lytic replication in Epstein–Barr virus-associated oncogenesis

(2019) Christian Münz   NATURE REVIEWS MICROBIOLOGY

The T-cell Response to Epstein-Barr Virus–New Tricks From an Old Dog

(2019) Heather M. Long et al.   Frontiers in Immunology

The Global Landscape of EBV-Associated Tumors

(2019) Claire Shannon-Lowe et al.   Frontiers in Oncology

Primary Epstein-Barr virus infection with and without infectious mononucleosis

(2019) Klaus Rostgaard et al.   PLoS One

Comparative analysis of the viral interferon regulatory factors of KSHV for their requisite for virus production and inhibition of the type I interferon pathway

(2019) Gavin Golas et al.   VIROLOGY

Global burden of cancer attributable to infections in 2018: a worldwide incidence analysis

(2019) Catherine de Martel et al.   Lancet Global Health

Cell therapies for hematological malignancies: don't forget non-gene-modified t cells!

(2018) Melanie L. Grant et al.   BLOOD REVIEWS

Human herpesvirus–encoded kinase induces B cell lymphomas in vivo

(2018) Penny M. Anders et al.   JOURNAL OF CLINICAL INVESTIGATION

Primary Epstein-Barr virus infection

(2018) Samantha K. Dunmire et al.   JOURNAL OF CLINICAL VIROLOGY

Primary effusion lymphoma: current perspectives

(2018) Mayur Narkhede et al.   OncoTargets and Therapy

EBV persistence without its EBNA3A and 3C oncogenes in vivo

(2018) Anita Murer et al.   PLoS Pathogens

Epstein-Barr virus nuclear antigen EBNA-LP is essential for transforming naïve B cells, and facilitates recruitment of transcription factors to the viral genome

(2018) Agnieszka Szymula et al.   PLoS Pathogens

Epstein–Barr Virus and Cancer

(2018) Paul J. Farrell   Annual Review of Pathology-Mechanisms of Disease

Contribution of the KSHV and EBV lytic cycles to tumourigenesis

(2018) Oliver Manners et al.   Current Opinion in Virology

A cancer-associated Epstein-Barr virus BZLF1 promoter variant enhances lytic infection

(2018) Jillian A. Bristol et al.   PLoS Pathogens

CCR5 antagonism by maraviroc inhibits Hodgkin lymphoma microenvironment interactions and xenograft growth

(2018) Naike Casagrande et al.   HAEMATOLOGICA

Epstein–Barr virus enhances genome maintenance of Kaposi sarcoma-associated herpesvirus

(2018) Rachele Bigi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EBV MicroRNA BART16 Suppresses Type I IFN Signaling

(2017) Marjolein J. G. Hooykaas et al.   JOURNAL OF IMMUNOLOGY

Epstein-Barr Virus miR-BART6-3p Inhibits the RIG-I Pathway

(2017) Yuanjun Lu et al.   Journal of Innate Immunity

Chemokines encoded by herpesviruses

(2017) Sergio M. Pontejo et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Multiple viral infections in primary effusion lymphoma: a model of viral cooperation in lymphomagenesis

(2017) Annunziata Gloghini et al.   Expert Review of Hematology

BALB/c mice immunized with a combination of virus-like particles incorporating Kaposi sarcoma-associated herpesvirus (KSHV) envelope glycoproteins gpK8.1, gB, and gH/gL induced comparable serum neutralizing antibody activity to UV-inactivated KSHV

(2017) Anne K. Barasa et al.   Oncotarget

T-cell responses to KSHV infection: a systematic approach

(2017) Romin Roshan et al.   Oncotarget

Lytic EBV infection investigated by detection of Soluble Epstein-Barr virus ZEBRA in the serum of patients with PTLD

(2017) Mohammed Habib et al.   Scientific Reports

Kaposi sarcoma–associated herpesvirus: immunobiology, oncogenesis, and therapy

(2016) Dirk P. Dittmer et al.   JOURNAL OF CLINICAL INVESTIGATION

Hairy leukoplakia; lessons learned: 30-plus years

(2016) JS Greenspan et al.   ORAL DISEASES

KSHV-encoded vIL-6 collaborates with deregulated c-Myc to drive plasmablastic neoplasms in mice

(2016) T R Rosean et al.   Blood Cancer Journal

PD-1 mediates functional exhaustion of activated NK cells in patients with Kaposi sarcoma

(2016) Asma Beldi-Ferchiou et al.   Oncotarget

The tumor virus landscape of AIDS-related lymphomas

(2015) A. Arvey et al.   BLOOD

B cells from nuclear factor kB essential modulator deficient patients fail to differentiate to antibody secreting cells in response to TLR9 ligand

(2015) Giuliana Giardino et al.   CLINICAL IMMUNOLOGY

Antineoplastic effects of liposomal short interfering RNA treatment targeting BLIMP1/PRDM1 in primary effusion lymphoma

(2015) G. Riva et al.   HAEMATOLOGICA

Cytokine-Mediated Loss of Blood Dendritic Cells During Epstein-Barr Virus–Associated Acute Infectious Mononucleosis: Implication for Immune Dysregulation

(2015) Archana Panikkar et al.   JOURNAL OF INFECTIOUS DISEASES

Induction of the Lytic Cycle Sensitizes Epstein-Barr Virus-Infected B Cells to NK Cell Killing That Is Counteracted by Virus-Mediated NK Cell Evasion Mechanisms in the Late Lytic Cycle

(2015) Luke R. Williams et al.   JOURNAL OF VIROLOGY

Microenvironment and HIV-related lymphomagenesis

(2015) Liron Pantanowitz et al.   SEMINARS IN CANCER BIOLOGY

Kaposi Sarcoma-associated Herpesvirus: mechanisms of oncogenesis

(2015) Thomas F Schulz et al.   Current Opinion in Virology

The Incubation Period of Primary Epstein-Barr Virus Infection: Viral Dynamics and Immunologic Events

(2015) Samantha K. Dunmire et al.   PLoS Pathogens

Early Virological and Immunological Events in Asymptomatic Epstein-Barr Virus Infection in African Children

(2015) Shamanthi Jayasooriya et al.   PLoS Pathogens

Antineoplastic effects of liposomal short interfering RNA treatment targeting BLIMP1/PRDM1 in primary effusion lymphoma

(2015) G. Riva et al.   HAEMATOLOGICA

Role for early-differentiated natural killer cells in infectious mononucleosis

(2014) T. Azzi et al.   BLOOD

A Recombinant Modified Vaccinia Ankara Vaccine Encoding Epstein-Barr Virus (EBV) Target Antigens: A Phase I Trial in UK Patients with EBV-Positive Cancer

(2014) G. S. Taylor et al.   CLINICAL CANCER RESEARCH

  + T Cells Involvement in Viral Immune Control of Chronic Human Herpesvirus 8 Infection

(2014) S. Barcy et al.   JOURNAL OF IMMUNOLOGY

Whole-Genome Sequencing IdentifiesSTAT4as a Putative Susceptibility Gene in Classic Kaposi Sarcoma

(2014) Mervi Aavikko et al.   JOURNAL OF INFECTIOUS DISEASES

Kaposi's Sarcoma-Associated Herpesvirus K3 and K5 Ubiquitin E3 Ligases Have Stage-Specific Immune Evasion Roles during Lytic Replication

(2014) K. Brulois et al.   JOURNAL OF VIROLOGY

Cellular Differentiation Regulator BLIMP1 Induces Epstein-Barr Virus Lytic Reactivation in Epithelial and B Cells by Activating Transcription from both the R and Z Promoters

(2014) Jessica A. Reusch et al.   JOURNAL OF VIROLOGY

Contribution of Viral Mimics of Cellular Genes to KSHV Infection and Disease

(2014) Shuhei Sakakibara et al.   Viruses-Basel

Adoptive Transfer of EBV Specific CD8+ T Cell Clones Can Transiently Control EBV Infection in Humanized Mice

(2014) Olga Antsiferova et al.   PLoS Pathogens

The Genetic Theory of Infectious Diseases: A Brief History and Selected Illustrations

(2013) Jean-Laurent Casanova et al.   Annual Review of Genomics and Human Genetics

Gammaherpesviruses and Lymphoproliferative Disorders

(2013) Ethel Cesarman   Annual Review of Pathology-Mechanisms of Disease

Phase I Trial of Recombinant Modified Vaccinia Ankara Encoding Epstein-Barr Viral Tumor Antigens in Nasopharyngeal Carcinoma Patients

(2013) E. P. Hui et al.   CANCER RESEARCH

MHC II tetramers visualize human CD4+T cell responses to Epstein–Barr virus infection and demonstrate atypical kinetics of the nuclear antigen EBNA1 response

(2013) Heather M. Long et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD8+ T Cell Responses to Lytic EBV Infection: Late Antigen Specificities as Subdominant Components of the Total Response

(2013) R. J. M. Abbott et al.   JOURNAL OF IMMUNOLOGY

Epstein-Barr Virus Transcytosis through Polarized Oral Epithelial Cells

(2013) S. M. Tugizov et al.   JOURNAL OF VIROLOGY

Distinct Roles of Kaposi's Sarcoma-Associated Herpesvirus-Encoded Viral Interferon Regulatory Factors in Inflammatory Response and Cancer

(2013) P. Baresova et al.   JOURNAL OF VIROLOGY

Epstein-Barr Virus Deubiquitinase Downregulates TRAF6-Mediated NF- B Signaling during Productive Replication

(2013) S. Saito et al.   JOURNAL OF VIROLOGY

KSHV LANA and EBV LMP1 induce the expression of UCH-L1 following viral transformation

(2013) Gretchen L. Bentz et al.   VIROLOGY

Human Natural Killer Cells Prevent Infectious Mononucleosis Features by Targeting Lytic Epstein-Barr Virus Infection

(2013) Obinna Chijioke et al.   Cell Reports

The Viral KSHV Chemokine vMIP-II Inhibits the Migration of Naive and Activated Human NK Cells by Antagonizing Two Distinct Chemokine Receptors

(2013) Rachel Yamin et al.   PLoS Pathogens

HHV-8-encoded viral IL-6 collaborates with mouse IL-6 in the development of multicentric Castleman disease in mice

(2012) J. Suthaus et al.   BLOOD

Cutting Edge: miR-223 and EBV miR-BART15 Regulate the NLRP3 Inflammasome and IL-1  Production

(2012) M. Haneklaus et al.   JOURNAL OF IMMUNOLOGY

Behavioral, Virologic, and Immunologic Factors Associated With Acquisition and Severity of Primary Epstein–Barr Virus Infection in University Students

(2012) Henry H. Balfour et al.   JOURNAL OF INFECTIOUS DISEASES

Kaposi's Sarcoma-Associated Herpesvirus MicroRNAs Target IRAK1 and MYD88, Two Components of the Toll-Like Receptor/Interleukin-1R Signaling Cascade, To Reduce Inflammatory-Cytokine Expression

(2012) J. R. Abend et al.   JOURNAL OF VIROLOGY

The EBV Immunoevasins vIL-10 and BNLF2a Protect Newly Infected B Cells from Immune Recognition and Elimination

(2012) Simon Jochum et al.   PLoS Pathogens

Human Herpesvirus 8 (HHV8) Sequentially Shapes the NK Cell Repertoire during the Course of Asymptomatic Infection and Kaposi Sarcoma

(2012) Stéphanie Dupuy et al.   PLoS Pathogens

Human TLRs and IL-1Rs in Host Defense: Natural Insights from Evolutionary, Epidemiological, and Clinical Genetics

(2011) Jean-Laurent Casanova et al.   Annual Review of Immunology

Epstein-Barr virus and multiple sclerosis: interaction with HLA

(2011) E Sundqvist et al.   GENES AND IMMUNITY

Viral Interleukin-6: Role in Kaposi's Sarcoma-Associated Herpesvirus–Associated Malignancies

(2011) Shuhei Sakakibara et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

A Virus-Like Particle-Based Epstein-Barr Virus Vaccine

(2011) R. Ruiss et al.   JOURNAL OF VIROLOGY

Persistent Infection Drives the Development of CD8+ T Cells Specific for Late Lytic Infection Antigens in Lymphocryptovirus-Infected Macaques and Epstein-Barr Virus-Infected Humans

(2011) N. Orlova et al.   JOURNAL OF VIROLOGY

Discovery of a Viral NLR Homolog that Inhibits the Inflammasome

(2011) S. M. Gregory et al.   SCIENCE

Epstein-Barr Virus: An Important Vaccine Target for Cancer Prevention

(2011) J. I. Cohen et al.   Science Translational Medicine

Inborn errors of anti-viral interferon immunity in humans

(2011) Vanessa Sancho-Shimizu et al.   Current Opinion in Virology

An ATM/Chk2-Mediated DNA Damage-Responsive Signaling Pathway Suppresses Epstein-Barr Virus Transformation of Primary Human B Cells

(2010) Pavel A. Nikitin et al.   Cell Host & Microbe

Monofunctional and Polyfunctional CD8+ T Cell Responses to Human Herpesvirus 8 Lytic and Latency Proteins

(2010) L. Lepone et al.   Clinical and Vaccine Immunology

Mechanisms of Autoinhibition of IRF-7 and a Probable Model for Inactivation of IRF-7 by Kaposi's Sarcoma-associated Herpesvirus Protein ORF45

(2010) Narayanan Sathish et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kaposi Sarcoma-associated Herpesvirus Latency-associated Nuclear Antigen Inhibits Interferon (IFN) β Expression by Competing with IFN Regulatory Factor-3 for Binding toIFNBPromoter

(2010) Nathalie Cloutier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EBV Lytic-Phase Protein BGLF5 Contributes to TLR9 Downregulation during Productive Infection

(2010) M. van Gent et al.   JOURNAL OF IMMUNOLOGY

Convergence of Kaposi's Sarcoma-Associated Herpesvirus Reactivation with Epstein-Barr Virus Latency and Cellular Growth Mediated by the Notch Signaling Pathway in Coinfected Cells

(2010) Sophia Spadavecchia et al.   JOURNAL OF VIROLOGY

A New Model of Epstein-Barr Virus Infection Reveals an Important Role for Early Lytic Viral Protein Expression in the Development of Lymphomas

(2010) S.-D. Ma et al.   JOURNAL OF VIROLOGY

Epstein-Barr virus-encoded EBNA1 inhibits the canonical NF-κB pathway in carcinoma cells by inhibiting IKK phosphorylation

(2010) Robert Valentine et al.   Molecular Cancer

A model for harmonizing flow cytometry in clinical trials

(2010) Holden T Maecker et al.   NATURE IMMUNOLOGY

Cellular immune responses and disease control in acute AIDS-associated Kaposiʼs sarcoma

(2009) Florian Bihl et al.   AIDS

Induction of CCL20 production by Kaposi's sarcoma-associated herpesvirus: role of viral FLICE inhibitory protein K13-induced NF- B activation

(2009) V. Punj et al.   BLOOD

Diverse Herpesvirus MicroRNAs Target the Stress-Induced Immune Ligand MICB to Escape Recognition by Natural Killer Cells

(2009) Daphna Nachmani et al.   Cell Host & Microbe

Regulation of the Epstein-Barr virus Zp promoter in B lymphocytes during reactivation from latency

(2009) C. McDonald et al.   JOURNAL OF GENERAL VIROLOGY

The CD8 and CD4 T-Cell Response against Kaposi's Sarcoma-Associated Herpesvirus Is Skewed Towards Early and Late Lytic Antigens

(2009) Rebecca C. Robey et al.   PLoS One

EBV Is Necessary for Proliferation of Dually Infected Primary Effusion Lymphoma Cells

(2008) A. A. Mack et al.   CANCER RESEARCH

Epstein-Barr Virus BGLF4 Kinase Suppresses the Interferon Regulatory Factor 3 Signaling Pathway

(2008) J.-T. Wang et al.   JOURNAL OF VIROLOGY

Mutual Inhibition between Kaposi's Sarcoma-Associated Herpesvirus and Epstein-Barr Virus Lytic Replication Initiators in Dually-Infected Primary Effusion Lymphoma

(2008) Yanjun Jiang et al.   PLoS One

Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity

(2008) M. Thomas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA