Synthetic biology of extremophiles: a new wave of biomanufacturing

Polyhydroxyalkanoates synthesis by halophiles and thermophiles: towards sustainable production of microbial bioplastics

(2022) Stanislav Obruča et al.   BIOTECHNOLOGY ADVANCES

Hyperproduction of PHA copolymers containing high fractions of 4‐hydroxybutyrate (4HB) by outer membrane‐defected Halomonas bluephagenesis grown in bioreactors

(2022) Ziyu Wang et al.   Microbial Biotechnology

Engineered Halomonas spp. for production of l-Lysine and cadaverine

(2022) Cuihuan Zhao et al.   BIORESOURCE TECHNOLOGY

Merging automation and fundamental discovery into the design–build–test–learn cycle of nontraditional microbes

(2022) Nicolás Gurdo et al.   TRENDS IN BIOTECHNOLOGY

Identification of genome integration sites for developing a CRISPR‐based gene expression toolkit in Yarrowia lipolytica

(2022) Xiaoqin Liu et al.   Microbial Biotechnology

Rapid Quantification of Polyhydroxyalkanoates Accumulated in Living Cells Based on Green Fluorescence Protein-Labeled Phasins: The qPHA Method

(2022) Xu Liu et al.   BIOMACROMOLECULES

Engineering an oleic acid-induced system for Halomonas, E. coli and Pseudomonas

(2022) Yueyuan Ma et al.   METABOLIC ENGINEERING

Establishment of genetic tools for genomic DNA engineering of Halomonas sp. KM-1, a bacterium with potential for biochemical production

(2022) Ayaka Tsuji et al.   Microbial Cell Factories

Non-Sterilized Fermentation of 2,3-Butanediol with Seawater by Metabolic Engineered Fast-Growing Vibrio natriegens

(2022) Wensi Meng et al.   Frontiers in Bioengineering and Biotechnology

Deficiency of exopolysaccharides and O-antigen makes Halomonas bluephagenesis self-flocculating and amenable to electrotransformation

(2022) Tong Xu et al.   Communications Biology

Engineering Halomonas bluephagenesis via small regulatory RNAs

(2022) Li-Juan Wang et al.   METABOLIC ENGINEERING

Engineering Halomonas bluephagenesis as a chassis for bioproduction from starch

(2021) Yina Lin et al.   METABOLIC ENGINEERING

Systems metabolic engineering of Vibrio natriegens for the production of 1,3-propanediol

(2021) Ye Zhang et al.   METABOLIC ENGINEERING

Hyperproduction of 3-hydroxypropionate by Halomonas bluephagenesis

(2021) Xiao-Ran Jiang et al.   Nature Communications

Reversible thermal regulation for bifunctional dynamic control of gene expression in Escherichia coli

(2021) Xuan Wang et al.   Nature Communications

Integration of metabolic pathway manipulation and promoter engineering for the fine‐tuned biosynthesis of malic acid in Bacillus coagulans

(2021) Wenhui Sun et al.   BIOTECHNOLOGY AND BIOENGINEERING

Halomonas as a chassis

(2021) Jian-Wen Ye et al.   Essays in Biochemistry

Engineering the permeability of Halomonas bluephagenesis enhanced its chassis properties

(2021) Ziyu Wang et al.   METABOLIC ENGINEERING

Towards bio-upcycling of polyethylene terephthalate

(2021) Till Tiso et al.   METABOLIC ENGINEERING

A critical review on various feedstocks as sustainable substrates for biosurfactants production: a way towards cleaner production

(2021) Swayansu Sabyasachi Mohanty et al.   Microbial Cell Factories

Microbial production of advanced biofuels

(2021) Jay Keasling et al.   NATURE REVIEWS MICROBIOLOGY

A review on production of polyhydroxyalkanoate (PHA) biopolyesters by thermophilic microbes using waste feedstocks

(2021) Shraddha Chavan et al.   BIORESOURCE TECHNOLOGY

A promoter engineering-based strategy enhances polyhydroxyalkanoate production in Pseudomonas putida KT2440

(2021) Yiting Zhang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

SEVAtile: a standardised DNA assembly method optimised for Pseudomonas

(2021) Eveline‐Marie Lammens et al.   Microbial Biotechnology

Biochemical routes for uptake and conversion of xylose by microorganisms

(2020) Zhe Zhao et al.   Biotechnology for Biofuels

Biosynthesis of functional polyhydroxyalkanoates by engineered Halomonas bluephagenesis

(2020) Lin-Ping Yu et al.   METABOLIC ENGINEERING

Bacteria as an alternate biofactory for carotenoid production: A review of its applications, opportunities and challenges

(2020) Shristi Ram et al.   Journal of Functional Foods

Engineering Halomonas bluephagenesis for L-Threonine production

(2020) Hetong Du et al.   METABOLIC ENGINEERING

The Archaeal Proteome Project advances knowledge about archaeal cell biology through comprehensive proteomics

(2020) Stefan Schulze et al.   Nature Communications

Rational flux-tuning of Halomonas bluephagenesis for co-production of bioplastic PHB and ectoine

(2020) Hong Ma et al.   Nature Communications

Recent Development of Extremophilic Bacteria and Their Application in Biorefinery

(2020) Daochen Zhu et al.   Frontiers in Bioengineering and Biotechnology

Exploring the synthetic biology potential of bacteriophages for engineering non-model bacteria

(2020) Eveline-Marie Lammens et al.   Nature Communications

Architectures for Combined Transcriptional and Translational Resource Allocation Controllers

(2020) Alexander P.S. Darlington et al.   Cell Systems

Microbial engineering for easy downstream processing

(2019) Ying Wang et al.   BIOTECHNOLOGY ADVANCES

Thermophiles and the applications of their enzymes as new biocatalysts

(2019) Joaquín Atalah et al.   BIORESOURCE TECHNOLOGY

Living at the Extremes: Extremophiles and the Limits of Life in a Planetary Context

(2019) Nancy Merino et al.   Frontiers in Microbiology

Metabolic engineering of Clostridium thermocellum for n-butanol production from cellulose

(2019) Liang Tian et al.   Biotechnology for Biofuels

Chromosome engineering of the TCA cycle in Halomonas bluephagenesis for production of copolymers of 3-hydroxybutyrate and 3-hydroxyvalerate (PHBV)

(2019) Yong Chen et al.   METABOLIC ENGINEERING

Manipulation of polyhydroxyalkanoate granular sizes in Halomonas bluephagenesis

(2019) Rui Shen et al.   METABOLIC ENGINEERING

Cell density-dependent auto-inducible promoters for expression of recombinant proteins in Pseudomonas putida

(2019) Annika Meyers et al.   Microbial Biotechnology

Advances in Using Hansenula polymorpha as Chassis for Recombinant Protein Production

(2019) João Heitor Colombelli Manfrão-Netto et al.   Frontiers in Bioengineering and Biotechnology

Organic Wastes as Feedstocks for Non-Conventional Yeast-Based Bioprocesses

(2019) Diem T. Hoang Do et al.   Microorganisms

High ectoine production by an engineered Halomonas hydrothermalis Y2 in a reduced salinity medium

(2019) Qi Zhao et al.   Microbial Cell Factories

SEVA 3.0: an update of the Standard European Vector Architecture for enabling portability of genetic constructs among diverse bacterial hosts

(2019) Esteban Martínez-García et al.   NUCLEIC ACIDS RESEARCH

Microbial valorization of waste cooking oils for valuable compounds production – a review

(2019) Marlene Lopes et al.   CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY

Metal and organic pollutants bioremediation by extremophile microorganisms

(2019) Patricia Giovanella et al.   JOURNAL OF HAZARDOUS MATERIALS

Stimulus response-based fine-tuning of polyhydroxyalkanoate pathway in Halomonas

(2019) Jianwen Ye et al.   METABOLIC ENGINEERING

Multiple-Site Diversification of Regulatory Sequences Enables Interspecies Operability of Genetic Devices

(2019) Angeles Hueso-Gil et al.   ACS Synthetic Biology

Development of a cost-effective production process for Halomonas levan

(2018) Burak Adnan Erkorkmaz et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Low-pH production of d -lactic acid using newly isolated acid tolerant yeast Pichia kudriavzevii NG7

(2018) Hyun Joo Park et al.   BIOTECHNOLOGY AND BIOENGINEERING

Pilot Scale-up of Poly(3-hydroxybutyrate-co -4-hydroxybutyrate) Production by Halomonas bluephagenesis via Cell Growth Adapted Optimization Process

(2018) Jianwen Ye et al.   Biotechnology Journal

Next generation industrial biotechnology based on extremophilic bacteria

(2018) Guo-Qiang Chen et al.   CURRENT OPINION IN BIOTECHNOLOGY

Designing artificial metabolic pathways, construction of target enzymes, and analysis of their function

(2018) Yutaro Mori et al.   CURRENT OPINION IN BIOTECHNOLOGY

Engineering of Halomonas bluephagenesis for low cost production of poly(3-hydroxybutyrate- co -4-hydroxybutyrate) from glucose

(2018) Jianwen Ye et al.   METABOLIC ENGINEERING

Increasing oxygen availability for improving poly(3-hydroxybutyrate) production by Halomonas

(2018) Pengfei Ouyang et al.   METABOLIC ENGINEERING

CRISPR/Cas9 editing genome of extremophile Halomonas spp.

(2018) Qin Qin et al.   METABOLIC ENGINEERING

Promoter Engineering for Enhanced P(3HB-co-4HB) Production by Halomonas bluephagenesis

(2018) Rui SHEN et al.   ACS Synthetic Biology

Pilot Scale-up of Poly(3-hydroxybutyrate-co -4-hydroxybutyrate) Production by Halomonas bluephagenesis via Cell Growth Adapted Optimization Process

(2018) Jianwen Ye et al.   Biotechnology Journal

Engineering the Salt-Inducible Ectoine Promoter Region of Halomonas elongata for Protein Expression in a Unique Stabilizing Environment

(2018) et al.   Genes

Ribosomal binding site sequences and promoters for expressing glutamate decarboxylase and producing γ-aminobutyrate in Corynebacterium glutamicum

(2018) Feng Shi et al.   AMB Express

Engineering NADH/NAD+ ratio in Halomonas bluephagenesis for enhanced production of polyhydroxyalkanoates (PHA)

(2018) Chen Ling et al.   METABOLIC ENGINEERING

Metabolic engineering of Escherichia coli for de novo biosynthesis of vitamin B12

(2018) Huan Fang et al.   Nature Communications

Response Surface Methodology for the Optimization of Ultrasound-Assisted Extraction of Tetrodotoxin from the Liver of Takifugu pseudommus

(2018) Xiaojun Zhang et al.   Toxins

The genetic insulator RiboJ increases expression of insulated genes

(2018) Kalen P. Clifton et al.   Journal of Biological Engineering

Novel T7-like expression systems used for Halomonas

(2017) Han Zhao et al.   METABOLIC ENGINEERING

Controlling cell volume for efficient PHB production by Halomonas

(2017) Xiao-Ran Jiang et al.   METABOLIC ENGINEERING

Engineering Halomonas species TD01 for enhanced polyhydroxyalkanoates synthesis via CRISPRi

(2017) Wei Tao et al.   Microbial Cell Factories

Dynamic regulation of metabolic flux in engineered bacteria using a pathway-independent quorum-sensing circuit

(2017) Apoorv Gupta et al.   NATURE BIOTECHNOLOGY

Industrial biomanufacturing: The future of chemical production

(2017) James M. Clomburg et al.   SCIENCE

Efficient production and secretion of oxaloacetate from Halomonas sp. KM-1 under aerobic conditions

(2017) Asuka Hannya et al.   AMB Express

Wide pH range tolerance in extremophiles: towards understanding an important phenomenon for future biotechnology

(2016) Kusum Dhakar et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

EngineeringHalomonasspp. as A Low-Cost Production Host for Production of Bio-surfactant Protein PhaP

(2016) Lu-Hong Lan et al.   Biotechnology Journal

Vibrio natriegens as a fast-growing host for molecular biology

(2016) Matthew T Weinstock et al.   NATURE METHODS

Sustainable biorefining in wastewater by engineered extreme alkaliphile Bacillus marmarensis

(2016) David G. Wernick et al.   Scientific Reports

EngineeringHalomonasspp. as A Low-Cost Production Host for Production of Bio-surfactant Protein PhaP

(2016) Lu-Hong Lan et al.   Biotechnology Journal

Efficient production and secretion of pyruvate from Halomonas sp. KM-1 under aerobic conditions

(2016) Yoshikazu Kawata et al.   AMB Express

A Two-Layer Gene Circuit for Decoupling Cell Growth from Metabolite Production

(2016) Tat-Ming Lo et al.   Cell Systems

Efficient Genome Editing in Clostridium cellulolyticum via CRISPR-Cas9 Nickase

(2015) Tao Xu et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Ecology and application of haloalkaliphilic anaerobic microbial communities

(2015) João A.B. Sousa et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Effects of chromosomal gene copy number and locations on polyhydroxyalkanoate synthesis by Escherichia coli and Halomonas sp.

(2015) Jin Yin et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Engineering of core promoter regions enables the construction of constitutive and inducible promoters in Halomonas sp.

(2015) Tingting Li et al.   Biotechnology Journal

Effective stimulating factors for microbial levan production by Halomonas smyrnensis AAD6T

(2015) Hande Kazak Sarilmiser et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Engineering Biosynthesis Mechanisms for Diversifying Polyhydroxyalkanoates

(2015) Guo-Qiang Chen et al.   TRENDS IN BIOTECHNOLOGY

Systematic Identification of a Panel of Strong Constitutive Promoters from Streptomyces albus

(2015) Yunzi Luo et al.   ACS Synthetic Biology

Engineering of core promoter regions enables the construction of constitutive and inducible promoters in Halomonas sp.

(2015) Tingting Li et al.   Biotechnology Journal

Development of an enhanced chromosomal expression system based on porin synthesis operon for halophile Halomonas sp.

(2014) Jin Yin et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

A seawater-based open and continuous process for polyhydroxyalkanoates production by recombinant Halomonas campaniensis LS21 grown in mixed substrates

(2014) Haitao Yue et al.   Biotechnology for Biofuels

Extremozymes—biocatalysts with unique properties from extremophilic microorganisms

(2014) Skander Elleuche et al.   CURRENT OPINION IN BIOTECHNOLOGY

Engineering Halomonas TD01 for the low-cost production of polyhydroxyalkanoates

(2014) Dan Tan et al.   METABOLIC ENGINEERING

Development of Halomonas TD01 as a host for open production of chemicals

(2014) Xiao-Zhi Fu et al.   METABOLIC ENGINEERING

Exploiting Issatchenkia orientalis SD108 for succinic acid production

(2014) Han Xiao et al.   Microbial Cell Factories

Microfluidic high-throughput culturing of single cells for selection based on extracellular metabolite production or consumption

(2014) Benjamin L Wang et al.   NATURE BIOTECHNOLOGY

Low pH d-xylonate production with Pichia kudriavzevii

(2013) Mervi Toivari et al.   BIORESOURCE TECHNOLOGY

Metabolic engineering of Thermoanaerobacterium saccharolyticum for n-butanol production

(2013) Ashwini Bhandiwad et al.   METABOLIC ENGINEERING

Biobased chemicals: the convergence of green chemistry with industrial biotechnology

(2013) Jim C. Philp et al.   TRENDS IN BIOTECHNOLOGY

Radiation-resistant extremophiles and their potential in biotechnology and therapeutics

(2012) Prashant Gabani et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

A review of lignocellulose bioconversion using enzymatic hydrolysis and synergistic cooperation between enzymes—Factors affecting enzymes, conversion and synergy

(2012) J.S. Van Dyk et al.   BIOTECHNOLOGY ADVANCES

The Arrhenius Equation Revisited

(2012) Micha Peleg et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

"Direct cloning in Lactobacillus plantarum: Electroporation with non-methylated plasmid DNA enhances transformation efficiency and makes shuttle vectors obsolete"

(2012) Katharina Spath et al.   Microbial Cell Factories

Unsterile and continuous production of polyhydroxybutyrate by Halomonas TD01

(2011) Dan Tan et al.   BIORESOURCE TECHNOLOGY

Molecular aspects of bacterial pH sensing and homeostasis

(2011) Terry A. Krulwich et al.   NATURE REVIEWS MICROBIOLOGY

High-Cell-Density Cyclic Fed-Batch Fermentation of a Poly(3-Hydroxybutyrate)-Accumulating Thermophile, Chelatococcus sp. Strain MW10

(2010) M. H. A. Ibrahim et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Fermentation Process Development of Recombinant Hansenula polymorpha for Gamma-Linolenic Acid Production

(2010) B. Khongto   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Metabolic engineering of Saccharomyces cerevisiae for the production of n-butanol

(2008) Eric J Steen et al.   Microbial Cell Factories