Engineering bacteria as interactive cancer therapies

Systemic immune responses to irradiated tumours via the transport of antigens to the tumour periphery by injected flagellate bacteria

(2022) Wenguang Wang et al.   Nature Biomedical Engineering

A programmable encapsulation system improves delivery of therapeutic bacteria in mice

(2022) Tetsuhiro Harimoto et al.   NATURE BIOTECHNOLOGY

Listeria delivers tetanus toxoid protein to pancreatic tumors and induces cancer cell death in mice

(2022) Benson Chellakkan Selvanesan et al.   Science Translational Medicine

Emerging strategies for engineering Escherichia coli Nissle 1917-based therapeutics

(2022) Jason P. Lynch et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Ultrasound-controllable engineered bacteria for cancer immunotherapy

(2022) Mohamad H. Abedi et al.   Nature Communications

Spatiotemporal control of engineered bacteria to express interferon-γ by focused ultrasound for tumor immunotherapy

(2022) Yuhao Chen et al.   Nature Communications

Magnetically steerable bacterial microrobots moving in 3D biological matrices for stimuli-responsive cargo delivery

(2022) Mukrime Birgul Akolpoglu et al.   Science Advances

Automated design of synthetic microbial communities

(2021) Behzad D. Karkaria et al.   Nature Communications

Identification of bacteria-derived HLA-bound peptides in melanoma

(2021) Shelly Kalaora et al.   NATURE

The microbiome and human cancer

(2021) Gregory D. Sepich-Poore et al.   SCIENCE

Scalable recombinase-based gene expression cascades

(2021) Tackhoon Kim et al.   Nature Communications

Theranostic cells: emerging clinical applications of synthetic biology

(2021) Monica P. McNerney et al.   NATURE REVIEWS GENETICS

Engineered Attenuated Salmonella typhimurium Expressing Neoantigen Has Anticancer Effects

(2021) Jungheun Hyun et al.   ACS Synthetic Biology

Enhancing the tropism of bacteria via genetically programmed biosensors

(2021) Tiffany Chien et al.   Nature Biomedical Engineering

Metabolic modulation of tumours with engineered bacteria for immunotherapy

(2021) Fernando P. Canale et al.   NATURE

Acoustically triggered mechanotherapy using genetically encoded gas vesicles

(2021) Avinoam Bar-Zion et al.   Nature Nanotechnology

Intracellular delivery of protein drugs with an autonomously lysing bacterial system reduces tumor growth and metastases

(2021) Vishnu Raman et al.   Nature Communications

853 ACTM-838: a microbial-based immunotherapy that delivers combination IL-15 + engineered STING to tumor-resident APCs after IV dosing in T-cell excluded solid tumors

(2021) Haixing Kehoe et al.   Journal for ImmunoTherapy of Cancer

Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies

(2020) Candice R. Gurbatri et al.   Science Translational Medicine

The human tumor microbiome is composed of tumor type–specific intracellular bacteria

(2020) Deborah Nejman et al.   SCIENCE

Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity

(2020) Daniel S. Leventhal et al.   Nature Communications

Salmonella-based platform for efficient delivery of functional binding proteins to the cytosol

(2020) Antoine Chabloz et al.   Communications Biology

A defined commensal consortium elicits CD8 T cells and anti-cancer immunity

(2019) Takeshi Tanoue et al.   NATURE

Detection of Tumors with Fluorophore‐Releasing Bacteria

(2019) Jan T. Panteli et al.   INTERNATIONAL JOURNAL OF CANCER

Programmable bacteria induce durable tumor regression and systemic antitumor immunity

(2019) Sreyan Chowdhury et al.   NATURE MEDICINE

Rock-paper-scissors: Engineered population dynamics increase genetic stability

(2019) Michael J. Liao et al.   SCIENCE

Bacteria-cancer interactions: bacteria-based cancer therapy

(2019) Mai Thi-Quynh Duong et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Designing microbial consortia with defined social interactions

(2018) Wentao Kong et al.   Nature Chemical Biology

Engineered commensal microbes for diet-mediated colorectal-cancer chemoprevention

(2018) Chun Loong Ho et al.   Nature Biomedical Engineering

Acoustic reporter genes for noninvasive imaging of microorganisms in mammalian hosts

(2018) Raymond W. Bourdeau et al.   NATURE

Two-step enhanced cancer immunotherapy with engineeredSalmonella typhimuriumsecreting heterologous flagellin

(2017) Jin Hai Zheng et al.   Science Translational Medicine

In vitro and ex vivo strategies for intracellular delivery

(2016) Martin P. Stewart et al.   NATURE

Synchronized cycles of bacterial lysis for in vivo delivery

(2016) M. Omar Din et al.   NATURE

Magneto-aerotactic bacteria deliver drug-containing nanoliposomes to tumour hypoxic regions

(2016) Ouajdi Felfoul et al.   Nature Nanotechnology

Engineering Salmonella as intracellular factory for effective killing of tumour cells

(2016) Eva María Camacho et al.   Scientific Reports

RGD Peptide Cell-Surface Display Enhances the Targeting and Therapeutic Efficacy of Attenuated Salmonella-mediated Cancer Therapy

(2016) Seung-Hwan Park et al.   Theranostics

Quorum-sensingSalmonellaselectively trigger protein expression within tumors

(2015) Charles A. Swofford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Programmable probiotics for detection of cancer in urine

(2015) Tal Danino et al.   Science Translational Medicine

Engineering Escherichia coli into a Protein Delivery System for Mammalian Cells

(2015) Analise Z. Reeves et al.   ACS Synthetic Biology

Bacterial-Mediated Knockdown of Tumor Resistance to an Oncolytic Virus Enhances Therapy

(2014) Michelle Cronin et al.   MOLECULAR THERAPY

Explicit hypoxia targeting with tumor suppression by creating an “obligate” anaerobic Salmonella Typhimurium strain

(2012) Bin Yu et al.   Scientific Reports

Tumor-targeting amino acid auxotrophic Salmonella typhimurium

(2009) Robert M. Hoffman   AMINO ACIDS

Engineering the Salmonella type III secretion system to export spider silk monomers

(2009) Daniel M Widmaier et al.   Molecular Systems Biology

Development of a Listeria monocytogenes based vaccine against prostate cancer

(2008) Vafa Shahabi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY