Vaccination induces HIV broadly neutralizing antibody precursors in humans

Increased memory B cell potency and breadth after a SARS-CoV-2 mRNA boost

(2022) Frauke Muecksch et al.   NATURE

Neutralization titer biomarker for antibody-mediated prevention of HIV-1 acquisition

(2022) Peter B. Gilbert et al.   NATURE MEDICINE

Rhesus and cynomolgus macaque immunoglobulin heavy-chain genotyping yields comprehensive databases of germline VDJ alleles

(2021) Néstor Vázquez Bernat et al.   IMMUNITY

Vaccination induces maturation in a mouse model of diverse unmutated VRC01-class precursors to HIV-neutralizing antibodies with >50% breadth

(2021) Xuejun Chen et al.   IMMUNITY

Two Randomized Trials of Neutralizing Antibodies to Prevent HIV-1 Acquisition

(2021) Lawrence Corey et al.   NEW ENGLAND JOURNAL OF MEDICINE

mRNA vaccination boosts cross-variant neutralizing antibodies elicited by SARS-CoV-2 infection

(2021) Leonidas Stamatatos et al.   SCIENCE

Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals following mRNA vaccination

(2021) Rishi R. Goel et al.   Science Immunology

SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses

(2021) Jackson S. Turner et al.   NATURE

Vaccine genetics of IGHV1-2 VRC01-class broadly neutralizing antibody precursor naïve human B cells

(2021) Jeong Hyun Lee et al.   npj Vaccines

Anti-SARS-CoV-2 receptor-binding domain antibody evolution after mRNA vaccination

(2021) Alice Cho et al.   NATURE

Observed Antibody Space: A diverse database of cleaned, annotated, and translated unpaired and paired antibody sequences

(2021) Tobias H. Olsen et al.   PROTEIN SCIENCE

High-affinity memory B cells induced by SARS-CoV-2 infection produce more plasmablasts and atypical memory B cells than those primed by mRNA vaccines

(2021) Kathryn A. Pape et al.   Cell Reports

Structural basis of glycan276-dependent recognition by HIV-1 broadly neutralizing antibodies

(2021) Christopher A. Cottrell et al.   Cell Reports

Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody

(2020) Philipp Schommers et al.   CELL

A Phase IIa Controlled Human Malaria Infection and Immunogenicity Study of RTS,S/AS01E and RTS,S/AS01B Delayed Fractional Dose Regimens in Malaria-Naïve Adults

(2020) James E Moon et al.   JOURNAL OF INFECTIOUS DISEASES

Multifaceted Effects of Antigen Valency on B Cell Response Composition and Differentiation In Vivo

(2020) Yu Kato et al.   IMMUNITY

Human germinal centres engage memory and naive B cells after influenza vaccination

(2020) Jackson S. Turner et al.   NATURE

B cells expressing authentic naive human VRC01-class BCRs can be recruited to germinal centers and affinity mature in multiple independent mouse models

(2020) Deli Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiplexed CRISPR/CAS9‐mediated engineering of pre‐clinical mouse models bearing native human B cell receptors

(2020) Xuesong Wang et al.   EMBO JOURNAL

Protein and Glycan Mimicry in HIV Vaccine Design

(2019) Gemma E. Seabright et al.   JOURNAL OF MOLECULAR BIOLOGY

Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization

(2019) Rui Kong et al.   CELL

Activation Dynamics and Immunoglobulin Evolution of Pre-existing and Newly Generated Human Memory B cell Responses to Influenza Hemagglutinin

(2019) Sarah F. Andrews et al.   IMMUNITY

Rapid and Focused Maturation of a VRC01-Class HIV Broadly Neutralizing Antibody Lineage Involves Both Binding and Accommodation of the N276-Glycan

(2019) Jeffrey Umotoy et al.   IMMUNITY

High-Quality Library Preparation for NGS-Based Immunoglobulin Germline Gene Inference and Repertoire Expression Analysis

(2019) Néstor Vázquez Bernat et al.   Frontiers in Immunology

A Meta-analysis of Passive Immunization Studies Shows that Serum-Neutralizing Antibody Titer Associates with Protection against SHIV Challenge

(2019) Amarendra Pegu et al.   Cell Host & Microbe

Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies

(2019) Celia C. LaBranche et al.   PLoS Pathogens

The how’s and what’s of vaccine reactogenicity

(2019) Caroline Hervé et al.   npj Vaccines

Extensive dissemination and intraclonal maturation of HIV Env vaccine-induced B cell responses

(2019) Ganesh E. Phad et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses

(2019) Jon M. Steichen et al.   SCIENCE

Rapid Germinal Center and Antibody Responses in Non-human Primates after a Single Nanoparticle Vaccine Immunization

(2019) Colin Havenar-Daughton et al.   Cell Reports

Restricted Clonality and Limited Germinal Center Reentry Characterize Memory B Cell Reactivation by Boosting

(2019) Luka Mesin et al.   CELL

Targeted selection of HIV-specific antibody mutations by engineering B cell maturation

(2019) Kevin O. Saunders et al.   SCIENCE

Overcoming Steric Restrictions of VRC01 HIV-1 Neutralizing Antibodies through Immunization

(2019) K. Rachael Parks et al.   Cell Reports

ggCyto: Next Generation Open-Source Visualization Software for Cytometry

(2018) Phu Van et al.   BIOINFORMATICS

Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens

(2018) Robert K. Abbott et al.   IMMUNITY

HIV-1 Envelope Glycoproteins from Diverse Clades Differentiate Antibody Responses and Durability among Vaccinees

(2018) Nicole L. Yates et al.   JOURNAL OF VIROLOGY

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1

(2018) Kai Xu et al.   NATURE MEDICINE

Anti–HIV-1 B cell responses are dependent on B cell precursor frequency and antigen-binding affinity

(2018) Pia Dosenovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen

(2018) Colin Havenar-Daughton et al.   Science Translational Medicine

HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope

(2018) Daniela Fera et al.   Nature Communications

BALDR: a computational pipeline for paired heavy and light chain immunoglobulin reconstruction in single-cell RNA-seq data

(2018) Amit A. Upadhyay et al.   Genome Medicine

When designing vaccines, consider the starting material: the human B cell repertoire

(2018) Colin Havenar-Daughton et al.   CURRENT OPINION IN IMMUNOLOGY

Glycan Masking Focuses Immune Responses to the HIV-1 CD4-Binding Site and Enhances Elicitation of VRC01-Class Precursor Antibodies

(2018) Hongying Duan et al.   IMMUNITY

Observed Antibody Space: A Resource for Data Mining Next-Generation Sequencing of Antibody Repertoires

(2018) Aleksandr Kovaltsuk et al.   JOURNAL OF IMMUNOLOGY

CytoML for cross‐platform cytometry data sharing

(2018) Greg Finak et al.   CYTOMETRY PART A

HIV-1 envelope glycan modifications that permit neutralization by germline-reverted VRC01-class broadly neutralizing antibodies

(2018) Celia C. LaBranche et al.   PLoS Pathogens

An HIV Vaccine Is Essential for Ending the HIV/AIDS Pandemic

(2017) Anthony S. Fauci   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo

(2017) Max Medina-Ramírez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

lmerTest Package: Tests in Linear Mixed Effects Models

(2017) Alexandra Kuznetsova et al.   Journal of Statistical Software

Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide

(2017) S. Munir Alam et al.   Science Translational Medicine

Staged induction of HIV-1 glycan–dependent broadly neutralizing antibodies

(2017) Mattia Bonsignori et al.   Science Translational Medicine

Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation

(2017) Tongqing Zhou et al.   Cell Reports

Targeted N-glycan deletion at the receptor-binding site retains HIV Env NFL trimer integrity and accelerates the elicited antibody response

(2017) Viktoriya Dubrovskaya et al.   PLoS Pathogens

Reproducibility and Reuse of Adaptive Immune Receptor Repertoire Data

(2017) Felix Breden et al.   Frontiers in Immunology

Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody

(2016) Mattia Bonsignori et al.   CELL

Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies

(2016) Bryan Briney et al.   CELL

Sequential Immunization Elicits Broadly Neutralizing Anti-HIV-1 Antibodies in Ig Knockin Mice

(2016) Amelia Escolano et al.   CELL

Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires

(2016) Ming Tian et al.   CELL

HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies

(2016) Jon M. Steichen et al.   IMMUNITY

HIV-1 Envelope Mimicry of Host Enzyme Kynureninase Does Not Disrupt Tryptophan Metabolism

(2016) Todd Bradley et al.   JOURNAL OF IMMUNOLOGY

Natively glycosylated HIV-1 Env structure reveals new mode for antibody recognition of the CD4-binding site

(2016) Harry B Gristick et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice

(2016) D. Sok et al.   SCIENCE

HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen

(2016) J. G. Jardine et al.   SCIENCE

Initiation of immune tolerance–controlled HIV gp41 neutralizing B cell lineages

(2016) Ruijun Zhang et al.   Science Translational Medicine

Antigen Presentation to B Cells

(2016) Balthasar A. Heesters et al.   TRENDS IN IMMUNOLOGY

Production of individualized V gene databases reveals high levels of immunoglobulin genetic diversity

(2016) Martin M. Corcoran et al.   Nature Communications

Natively glycosylated HIV-1 Env structure reveals new mode for antibody recognition of the CD4-binding site

(2016) Harry B Gristick et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Clonify: unseeded antibody lineage assignment from next-generation sequencing data

(2016) Bryan Briney et al.   Scientific Reports

Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design

(2016) Joseph G. Jardine et al.   PLoS Pathogens

Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice

(2015) Pia Dosenovic et al.   CELL

Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen

(2015) J. G. Jardine et al.   SCIENCE

Cooperation of B Cell Lineages in Induction of HIV-1-Broadly Neutralizing Antibodies

(2014) Feng Gao et al.   CELL

CD80 and PD-L2 define functionally distinct memory B cell subsets that are independent of antibody isotype

(2014) Griselda V Zuccarino-Catania et al.   NATURE IMMUNOLOGY

In-depth determination and analysis of the human paired heavy- and light-chain antibody repertoire

(2014) Brandon J DeKosky et al.   NATURE MEDICINE

Vaccine-Induced Env V1-V2 IgG3 Correlates with Lower HIV-1 Infection Risk and Declines Soon After Vaccination

(2014) N. L. Yates et al.   Science Translational Medicine

Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies

(2013) Tongqing Zhou et al.   IMMUNITY

Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies

(2013) Andrew T. McGuire et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Optimization and validation of the TZM-bl assay for standardized assessments of neutralizing antibodies against HIV-1

(2013) Marcella Sarzotti-Kelsoe et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Induction of HIV-1 Broad Neutralizing Antibodies in 2F5 Knock-in Mice: Selection against Membrane Proximal External Region-Associated Autoreactivity Limits T-Dependent Responses

(2013) L. Verkoczy et al.   JOURNAL OF IMMUNOLOGY

Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

(2013) Hua-Xin Liao et al.   NATURE

IgBLAST: an immunoglobulin variable domain sequence analysis tool

(2013) Jian Ye et al.   NUCLEIC ACIDS RESEARCH

Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors

(2013) J. Jardine et al.   SCIENCE

Recombinant HIV Envelope Proteins Fail to Engage Germline Versions of Anti-CD4bs bNAbs

(2013) Sam Hoot et al.   PLoS Pathogens

B-cell–lineage immunogen design in vaccine development with HIV-1 as a case study

(2012) Barton F Haynes et al.   NATURE BIOTECHNOLOGY

Structural basis for germ-line gene usage of a potent class of antibodies targeting the CD4-binding site of HIV-1 gp120

(2012) Anthony P. West et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of a Clonal Lineage of HIV-1 Envelope V2/V3 Conformational Epitope-Specific Broadly Neutralizing Antibodies and Their Inferred Unmutated Common Ancestors

(2011) M. Bonsignori et al.   JOURNAL OF VIROLOGY

Different B Cell Populations Mediate Early and Late Memory During an Endogenous Immune Response

(2011) K. A. Pape et al.   SCIENCE

Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding

(2011) J. F. Scheid et al.   SCIENCE

Crystal Structure of PG16 and Chimeric Dissection with Somatically Related PG9: Structure-Function Analysis of Two Quaternary-Specific Antibodies That Effectively Neutralize HIV-1

(2010) M. Pancera et al.   JOURNAL OF VIROLOGY

Therapeutic antibodies, vaccines and antibodyomes

(2010) Dimiter S. Dimitrov   mAbs

Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01

(2010) T. Zhou et al.   SCIENCE

Germline-like predecessors of broadly neutralizing antibodies lack measurable binding to HIV-1 envelope glycoproteins: Implications for evasion of immune responses and design of vaccine immunogens

(2009) Xiaodong Xiao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Maturation Pathways of Cross-Reactive HIV-1 Neutralizing Antibodies

(2009) Xiaodong Xiao et al.   Viruses-Basel

Initial B-Cell Responses to Transmitted Human Immunodeficiency Virus Type 1: Virion-Binding Immunoglobulin M (IgM) and IgG Antibodies Followed by Plasma Anti-gp41 Antibodies with Ineffective Control of Initial Viremia

(2008) G. D. Tomaras et al.   JOURNAL OF VIROLOGY