Saikosaponin D alleviates cancer cachexia by directly inhibiting STAT3

Potential Natural Products Against Respiratory Viruses: A Perspective to Develop Anti-COVID-19 Medicines

(2021) Marzieh Omrani et al.   Frontiers in Pharmacology

Integrative lipidomic and transcriptomic study unravels the therapeutic effects of saikosaponins A and D on non-alcoholic fatty liver disease

(2021) Xiaojiaoyang Li et al.   Acta Pharmaceutica Sinica B

Saikosaponin-d protects against liver fibrosis by regulating Estrogen receptor-β/NLRP3 inflammasome pathway

(2021) Liubing Lin et al.   Biochemistry and Cell Biology

Cancer Cachexia: Its Mechanism and Clinical Significance

(2021) Hiroki Nishikawa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cancer-Mediated Muscle Cachexia: Etiology and Clinical Management

(2021) Thomas Siff et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Saikosaponin A and D Inhibit Adipogenesis via the AMPK and MAPK Signaling Pathways in 3T3-L1 Adipocytes

(2021) Sung Ho Lim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Management of Cancer Cachexia: ASCO Guideline

(2020) Eric J. Roeland et al.   JOURNAL OF CLINICAL ONCOLOGY

Saikosaponin D: A potential therapeutic drug for osteoarthritis

(2020) Junsong Jiang et al.   Journal of Tissue Engineering and Regenerative Medicine

Imperatorin alleviates cancer cachexia and prevents muscle wasting via directly inhibiting STAT3

(2020) Linlin Chen et al.   PHARMACOLOGICAL RESEARCH

Inflammation and Skeletal Muscle Wasting During Cachexia

(2020) Justine M. Webster et al.   Frontiers in Physiology

Saikosaponin d ameliorates pancreatic fibrosis by inhibiting autophagy of pancreatic stellate cells via PI3K/Akt/mTOR pathway

(2019) Li-Hua Cui et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Epidemiology of weight loss, malnutrition and sarcopenia: a transatlantic view

(2019) Stéphane M. Schneider et al.   NUTRITION

Meeting Minimum ESPEN Energy Recommendations Is Not Enough to Maintain Muscle Mass in Head and Neck Cancer Patients

(2019) Benjamin McCurdy et al.   Nutrients

Biosensor-Based Active Ingredients Recognition System for Screening STAT3 Ligands from Medical Herbs

(2018) Langdong Chen et al.   ANALYTICAL CHEMISTRY

Cancer-associated cachexia

(2018) Vickie E. Baracos et al.   Nature Reviews Disease Primers

A comprehensive review and perspectives on pharmacology and toxicology of saikosaponins

(2018) Xiaojiaoyang Li et al.   PHYTOMEDICINE

The role of E3 ubiquitin-ligases MuRF-1 and MAFbx in loss of skeletal muscle mass

(2016) Oren Rom et al.   FREE RADICAL BIOLOGY AND MEDICINE

STAT3 in the systemic inflammation of cancer cachexia

(2016) Teresa A. Zimmers et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Saikosaponin-D reduces cisplatin-induced nephrotoxicity by repressing ROS-mediated activation of MAPK and NF-κB signalling pathways

(2015) Xiaobin Ma et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Inhibition of Stat3 Activation Suppresses Caspase-3 and the Ubiquitin-Proteasome System, Leading to Preservation of Muscle Mass in Cancer Cachexia

(2015) Kleiton Augusto Santos Silva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sorafenib and its derivative SC-1 exhibit antifibrotic effects through signal transducer and activator of transcription 3 inhibition

(2015) Tung-Hung Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagic effects of Chaihu (dried roots of Bupleurum Chinense DC or Bupleurum scorzoneraefolium WILD)

(2014) Betty Yuen-Kwan Law et al.   Chinese Medicine

Stat3 Activation Links a C/EBPδ to Myostatin Pathway to Stimulate Loss of Muscle Mass

(2013) Liping Zhang et al.   Cell Metabolism

Saikosaponin-d, a novel SERCA inhibitor, induces autophagic cell death in apoptosis-defective cells

(2013) V KW Wong et al.   Cell Death & Disease

Cytokine profile of conditioned medium from human tumor cell lines after acute and fractionated doses of gamma radiation and its effect on survival of bystander tumor cells

(2012) Sejal Desai et al.   CYTOKINE

Saikosaponin a and its epimer saikosaponin d exhibit anti-inflammatory activity by suppressing activation of NF-κB signaling pathway

(2012) Chun-Ni Lu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Definition and classification of cancer cachexia: an international consensus

(2011) Kenneth Fearon et al.   LANCET ONCOLOGY