Inhibition of Stat3 Activation Suppresses Caspase-3 and the Ubiquitin-Proteasome System, Leading to Preservation of Muscle Mass in Cancer Cachexia
Published 2015 View Full Article
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Title
Inhibition of Stat3 Activation Suppresses Caspase-3 and the Ubiquitin-Proteasome System, Leading to Preservation of Muscle Mass in Cancer Cachexia
Authors
Keywords
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Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 290, Issue 17, Pages 11177-11187
Publisher
American Society for Biochemistry & Molecular Biology (ASBMB)
Online
2015-03-19
DOI
10.1074/jbc.m115.641514
References
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Related references
Note: Only part of the references are listed.- Pancreatic Cancer-Induced Cachexia Is Jak2-Dependent in Mice
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- Nuclear transcription factor κ B activation and protein turnover adaptations in skeletal muscle of patients with progressive stages of lung cancer cachexia
- (2013) Céline M Op den Kamp et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- Stat3 Activation Links a C/EBPδ to Myostatin Pathway to Stimulate Loss of Muscle Mass
- (2013) Liping Zhang et al. Cell Metabolism
- Skeletal muscle glycoprotein 130's role in Lewis lung carcinoma–induced cachexia
- (2013) Melissa J. Puppa et al. FASEB JOURNAL
- Myostatin/activin pathway antagonism: Molecular basis and therapeutic potential
- (2013) H.Q. Han et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Signal regulatory protein-α interacts with the insulin receptor contributing to muscle wasting in chronic kidney disease
- (2013) Sandhya S. Thomas et al. KIDNEY INTERNATIONAL
- JAK/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia
- (2012) Andrea Bonetto et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- IL-6 regulation on skeletal muscle mitochondrial remodeling during cancer cachexia in the ApcMin/+ mouse
- (2012) James P White et al. Skeletal Muscle
- Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor
- (2011) M. S. Redell et al. BLOOD
- C/EBPβ mediates tumour-induced ubiquitin ligase atrogin1/MAFbx upregulation and muscle wasting
- (2011) Guohua Zhang et al. EMBO JOURNAL
- Pharmacological inhibition of myostatin suppresses systemic inflammation and muscle atrophy in mice with chronic kidney disease
- (2011) Liping Zhang et al. FASEB JOURNAL
- STAT3 Activation in Skeletal Muscle Links Muscle Wasting and the Acute Phase Response in Cancer Cachexia
- (2011) Andrea Bonetto et al. PLoS One
- Reversing Cachexia
- (2010) Michael J. Tisdale CELL
- Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival
- (2010) Xiaolan Zhou et al. CELL
- Caspase-3 Cleaves Specific 19 S Proteasome Subunits in Skeletal Muscle Stimulating Proteasome Activity
- (2010) Xiaonan H. Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- IL-6 and Serum Amyloid A Synergy Mediates Angiotensin II-Induced Muscle Wasting
- (2009) L. Zhang et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Mechanisms of Cancer Cachexia
- (2009) Michael J. Tisdale PHYSIOLOGICAL REVIEWS
- Chemical Probes that Competitively and Selectively Inhibit Stat3 Activation
- (2009) Xuejun Xu et al. PLoS One
- C/EBP regulates body composition, energy balance-related hormones and tumor growth
- (2008) J. Staiger et al. CARCINOGENESIS
- Cachexia: A new definition
- (2008) William J. Evans et al. CLINICAL NUTRITION
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