Risks of Infectious Disease in Xenotransplantation

First clinical‐grade porcine kidney xenotransplant using a human decedent model

(2022) Paige M. Porrett et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Rare isolation of human-tropic recombinant porcine endogenous retroviruses PERV-A/C from Göttingen minipigs

(2022) Sabrina Halecker et al.   Virology Journal

Results of Two Cases of Pig-to-Human Kidney Xenotransplantation

(2022) Robert A. Montgomery et al.   NEW ENGLAND JOURNAL OF MEDICINE

Progressive genetic modifications of porcine cardiac xenografts extend survival to 9 months

(2022) Muhammad M. Mohiuddin et al.   XENOTRANSPLANTATION

Progress in Xenotransplantation: Immunologic Barriers, Advances in Gene Editing, and Successful Tolerance Induction Strategies in Pig-To-Primate Transplantation

(2022) Daniel L. Eisenson et al.   Frontiers in Immunology

Genetically Modified Porcine-to-Human Cardiac Xenotransplantation

(2022) Bartley P. Griffith et al.   NEW ENGLAND JOURNAL OF MEDICINE

Expert Opinion Special Feature: Patient Selection for Initial Clinical Trials of Pig Organ Transplantation

(2022) Richard N. Pierson et al.   TRANSPLANTATION

Kidney transplantation from triple‐knockout pigs expressing multiple human proteins in cynomolgus macaques

(2021) David Ma et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Infectivity assessment of porcine endogenous retrovirus using high-throughput sequencing technologies

(2021) Ken Kono et al.   BIOLOGICALS

Porcine Endogenous Retroviruses and Xenotransplantation, 2021

(2021) Joachim Denner   Viruses-Basel

Coronavirus disease 2019 (COVID‐19) outbreak: Could pigs be vectors for human infections?

(2020) Tanja Opriessnig et al.   XENOTRANSPLANTATION

Progress Toward Cardiac Xenotransplantation

(2020) Richard N Pierson et al.   CIRCULATION

Swine acute diarrhea syndrome coronavirus replication in primary human cells reveals potential susceptibility to infection

(2020) Caitlin E. Edwards et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of porcine cytomegalovirus on long-term orthotopic cardiac xenotransplant survival

(2020) Joachim Denner et al.   Scientific Reports

Third WHO Global Consultation on Regulatory Requirements for Xenotransplantation Clinical Trials, Changsha, Hunan, China December 12–14, 2018

(2019) Wayne J. Hawthorne et al.   XENOTRANSPLANTATION

Genetically modified pigs as donors of cells, tissues, and organs for xenotransplantation

(2019) Eckhard Wolf et al.   Animal Frontiers

Characterization of porcine endogenous retrovirus particles released by the CRISPR/Cas9 inactivated cell line PK15 clone 15

(2019) Antonia W. Godehardt et al.   XENOTRANSPLANTATION

Porcine Prion Protein as a Paradigm of Limited Susceptibility to Prion Strain Propagation

(2019) Juan Carlos Espinosa et al.   JOURNAL OF INFECTIOUS DISEASES

Infectious disease risks in xenotransplantation

(2018) Jay A. Fishman   AMERICAN JOURNAL OF TRANSPLANTATION

Consistent success in life-supporting porcine cardiac xenotransplantation

(2018) Matthias Längin et al.   NATURE

Genetically Modified Pigs as Organ Donors for Xenotransplantation

(2017) Magdalena Hryhorowicz et al.   MOLECULAR BIOTECHNOLOGY

Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9

(2017) Dong Niu et al.   SCIENCE

Middle East respiratory syndrome coronavirus experimental transmission using a pig model

(2017) J. Vergara-Alert et al.   Transboundary and Emerging Diseases

No PERV transmission during a clinical trial of pig islet cell transplantation

(2017) Vladimir A. Morozov et al.   VIRUS RESEARCH

PERV inactivation is necessary to guarantee absence of pig-to-patient PERVs transmission in xenotransplantation

(2017) Marc Güell et al.   XENOTRANSPLANTATION

Can Antiretroviral Drugs Be Used to Treat Porcine Endogenous Retrovirus (PERV) Infection after Xenotransplantation?

(2017) Joachim Denner   Viruses-Basel

Progress in Clinical Encapsulated Islet Xenotransplantation

(2016) David K.C. Cooper et al.   TRANSPLANTATION

First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes-Executive summary

(2016) Bernhard J. Hering et al.   XENOTRANSPLANTATION

Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft

(2016) Muhammad M. Mohiuddin et al.   Nature Communications

Genome-wide inactivation of porcine endogenous retroviruses (PERVs)

(2015) L. Yang et al.   SCIENCE

PD-L1 expression is increased in monocyte derived dendritic cells in response to porcine circovirus type 2 and porcine reproductive and respiratory syndrome virus infections

(2015) O. Richmond et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Screening pigs for xenotransplantation: prevalence and expression of porcine endogenous retroviruses in Göttingen minipigs

(2015) Marwan Semaan et al.   XENOTRANSPLANTATION

Donor-derived infection—the challenge for transplant safety

(2014) Jay A. Fishman et al.   Nature Reviews Nephrology

Porcine Cytomegalovirus Infection Is Associated With Early Rejection of Kidney Grafts in a Pig to Baboon Xenotransplantation Model

(2014) Kazuhiko Yamada et al.   TRANSPLANTATION

Results of Life-Supporting Galactosyltransferase Knockout Kidneys in Cynomolgus Monkeys Using Two Different Sources of Galactosyltransferase Knockout Swine

(2014) Mitsuhiro Sekijima et al.   TRANSPLANTATION

Porcine endogenous retrovirus infection of human peripheral blood mononuclear cells

(2014) Joachim Denner   XENOTRANSPLANTATION

Microbiological safety of the first clinical pig islet xenotransplantation trial in New Zealand

(2014) Shaun Wynyard et al.   XENOTRANSPLANTATION

Analyses of pig genomes provide insight into porcine demography and evolution

(2012) Martien A. M. Groenen et al.   NATURE

The Epidemiology and Prevention of Donor-Derived Infections

(2009) Michael G. Ison   ADVANCES IN CHRONIC KIDNEY DISEASE

Donor-Derived Infections in Solid Organ Transplant Recipients

(2009) P. A. Grossi et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Inhibition of porcine endogenous retrovirus (PERV) replication by HIV-1 gene expression inhibitors

(2009) Minyi Shi et al.   ANTIVIRAL RESEARCH

Genetic manipulation in pigs

(2009) David H Sachs et al.   Current Opinion in Organ Transplantation

No evidence of porcine endogenous retrovirus in patients with type 1 diabetes after long-term porcine islet xenotransplantation

(2009) Rafael Valdes-Gonzalez et al.   JOURNAL OF MEDICAL VIROLOGY

Regulation of Porcine Endogenous Retrovirus Release by Porcine and Human Tetherins

(2009) G. Mattiuzzo et al.   JOURNAL OF VIROLOGY

Genetic modification of pigs as organ donors for xenotransplantation

(2009) Nikolai Klymiuk et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Human Fibroblasts Are Permissive for Porcine Cytomegalovirus In Vitro

(2009) Jennifer L. Whitteker et al.   TRANSPLANTATION

Executive summary

(2009) Bernhard J. Hering et al.   XENOTRANSPLANTATION

Distribution and expression of porcine endogenous retroviruses in multi-transgenic pigs generated for xenotransplantation

(2009) Britta Dieckhoff et al.   XENOTRANSPLANTATION

Porcine circovirus type 2-induced interleukin-10 modulates recall antigen responses

(2008) T. Kekarainen et al.   JOURNAL OF GENERAL VIROLOGY

Absence of transmission of potentially xenotic viruses in a prospective pig to primate islet xenotransplantation study

(2008) Olga Garkavenko et al.   JOURNAL OF MEDICAL VIROLOGY

Absence of Replication of Porcine Endogenous Retrovirus and Porcine Lymphotropic Herpesvirus Type 1 with Prolonged Pig Cell Microchimerism after Pig-to-Baboon Xenotransplantation

(2008) N. C. Issa et al.   JOURNAL OF VIROLOGY