Salsolinol Induces Parkinson’s Disease Through Activating NLRP3-Dependent Pyroptosis and the Neuroprotective Effect of Acteoside

Urolithin A promotes mitophagy and suppresses NLRP3 inflammasome activation in lipopolysaccharide-induced BV2 microglial cells and MPTP-induced Parkinson's disease model

(2022) Jingru Qiu et al.   NEUROPHARMACOLOGY

The role of Toll-like receptors and neuroinflammation in Parkinson’s disease

(2022) Arash Heidari et al.   Journal of Neuroinflammation

The pharmacokinetic property and pharmacological activity of acteoside: A review

(2022) Yaosheng Xiao et al.   BIOMEDICINE & PHARMACOTHERAPY

Berberine Protects Against NLRP3 Inflammasome via Ameliorating Autophagic Impairment in MPTP-Induced Parkinson’s Disease Model

(2021) Shuxuan Huang et al.   Frontiers in Pharmacology

Novel pentacyclic triterpenes exhibiting strong neuroprotective activity in SH-SY5Y cells in salsolinol- and glutamate-induced neurodegeneration models

(2021) Gabriel Gonzalez et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Acteoside exerts neuroprotection effects in the model of Parkinson's disease via inducing autophagy: Network pharmacology and experimental study

(2021) Mutalifu Aimaiti et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Melatonin Attenuates Neuroinflammation by Down-Regulating NLRP3 Inflammasome via a SIRT1-Dependent Pathway in MPTP-Induced Models of Parkinson’s Disease

(2021) Ran Zheng et al.   Journal of Inflammation Research

Perillyl Alcohol Attenuates NLRP3 Inflammasome Activation and Rescues Dopaminergic Neurons in Experimental In Vitro and In Vivo Models of Parkinson’s Disease

(2021) Sahabuddin Ahmed et al.   ACS Chemical Neuroscience

Kaemperfol alleviates pyroptosis and microglia-mediated neuroinflammation in Parkinson's disease via inhibiting p38MAPK/NF-κB signaling pathway

(2021) Meiyun Cai et al.   NEUROCHEMISTRY INTERNATIONAL

Hyperoside suppresses NLRP3 inflammasome in Parkinson's disease via Pituitary Adenylate Cyclase-Activating Polypeptide

(2021) Kai Wang et al.   NEUROCHEMISTRY INTERNATIONAL

Pharmacological Modulation of Nrf2/HO-1 Signaling Pathway as a Therapeutic Target of Parkinson’s Disease

(2021) Yumin Wang et al.   Frontiers in Pharmacology

Targeting Microglial α-Synuclein/TLRs/NF-kappaB/NLRP3 Inflammasome Axis in Parkinson’s Disease

(2021) Yunna Li et al.   Frontiers in Immunology

Baicalein Attenuates Neuroinflammation by Inhibiting NLRP3/caspase-1/GSDMD Pathway in MPTP Induced Mice Model of Parkinson’s Disease

(2020) Wenjuan Rui et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

NLRP3 Inflammasomes in Parkinson’s disease and their Regulation by Parkin

(2020) Yi-Qun Yan et al.   NEUROSCIENCE

Butyrate Protects Against Salsolinol-Induced Toxicity in SH-SY5Y Cells: Implication for Parkinson’s Disease

(2020) Bruk Getachew et al.   NEUROTOXICITY RESEARCH

Inflammation in Parkinson’s Disease: Mechanisms and Therapeutic Implications

(2020) Marta Pajares et al.   Cells

The Mechanism of Action of Salsolinol in Brain: Implications in Parkinson’s Disease

(2020) Shee Man Voon et al.   CNS & Neurological Disorders-Drug Targets

Antrodia camphorata polysaccharide resists 6‐OHDA‐induced dopaminergic neuronal damage by inhibiting ROS‐NLRP3 activation

(2020) Chenyang Han et al.   Brain and Behavior

Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease

(2019) Xiaojuan Han et al.   Autophagy

Acteoside ameliorates experimental autoimmune encephalomyelitis through inhibiting peroxynitrite-mediated mitophagy activation

(2019) Wenting Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration

(2018) Eunju Lee et al.   CELL DEATH AND DIFFERENTIATION

Acteoside protects against 6-OHDA-induced dopaminergic neuron damage via Nrf2-ARE signaling pathway

(2018) Maiquan Li et al.   FOOD AND CHEMICAL TOXICOLOGY

Salidroside Promotes the Pathological α-Synuclein Clearance Through Ubiquitin-Proteasome System in SH-SY5Y Cells

(2018) Tao Li et al.   Frontiers in Pharmacology

Bushen-Yizhi Formula Alleviates Neuroinflammation via Inhibiting NLRP3 Inflammasome Activation in a Mouse Model of Parkinson’s Disease

(2018) Yousheng Mo et al.   Evidence-based Complementary and Alternative Medicine

Acteoside Attenuates Oxidative Stress and Neuronal Apoptosis in Rats with Focal Cerebral Ischemia–Reperfusion Injury

(2018) Dongjian Xia et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

The mechanisms of NLRP3 inflammasome/pyroptosis activation and their role in Parkinson's disease

(2018) Shuo Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Epidemiology of Parkinson’s disease

(2017) Ole-Bjørn Tysnes et al.   JOURNAL OF NEURAL TRANSMISSION

Tenuigenin protects dopaminergic neurons from inflammation via suppressing NLRP3 inflammasome activation in microglia

(2017) Zheng Fan et al.   Journal of Neuroinflammation

Precision medicine for disease modification in Parkinson disease

(2017) Alberto J. Espay et al.   Nature Reviews Neurology

Salsolinol: an Unintelligible and Double-Faced Molecule—Lessons Learned from In Vivo and In Vitro Experiments

(2017) Magdalena Kurnik-Łucka et al.   NEUROTOXICITY RESEARCH

Parkinson's disease: Autoimmunity and neuroinflammation

(2016) Armando De Virgilio et al.   AUTOIMMUNITY REVIEWS

Acteoside Binds to Caspase-3 and Exerts Neuroprotection in the Rotenone Rat Model of Parkinson's Disease

(2016) Jiawen Yuan et al.   PLoS One

MDS clinical diagnostic criteria for Parkinson's disease

(2015) Ronald B. Postuma et al.   MOVEMENT DISORDERS

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Salsolinol Damaged Neuroblastoma SH-SY5Y Cells Induce Proliferation of Human Monocyte THP-1 Cells Through the mTOR Pathway in a Co-culture System

(2015) Fuli Wang et al.   NEUROCHEMICAL RESEARCH

Verbascoside — A review of its occurrence, (bio)synthesis and pharmacological significance

(2014) Kalina Alipieva et al.   BIOTECHNOLOGY ADVANCES

PACAP Protects Against Salsolinol-Induced Toxicity in Dopaminergic SH-SY5Y Cells: Implication for Parkinson’s Disease

(2013) Dwayne Brown et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Mechanism of action of salsolinol on tyrosine hydroxylase

(2013) Gabrielle D. Briggs et al.   NEUROCHEMISTRY INTERNATIONAL

Protective Effects of Curcumin Against Rotenone and Salsolinol-Induced Toxicity: Implications for Parkinson’s Disease

(2013) Zakiya Qualls et al.   NEUROTOXICITY RESEARCH

α-Synuclein and Neuronal Cell Death

(2012) Toru Yasuda et al.   MOLECULAR NEUROBIOLOGY

Low level of glutathione can intensify the toxic effect of salsolinol in SH-SY5Y neuroblastoma cell line

(2012) N. Wszelaki et al.   NEUROTOXICOLOGY

Upregulation of Heme Oxygenase-1 by Acteoside Through ERK and PI3 K/Akt Pathway Confer Neuroprotection Against Beta-Amyloid-Induced Neurotoxicity

(2011) Hong-Quan Wang et al.   NEUROTOXICITY RESEARCH

Astaxanthin upregulates heme oxygenase-1 expression through ERK1/2 pathway and its protective effect against beta-amyloid-induced cytotoxicity in SH-SY5Y cells

(2010) Hong-Quan Wang et al.   BRAIN RESEARCH

Acteoside protects human neuroblastoma SH-SY5Y cells against β-amyloid-induced cell injury

(2009) Hongquan Wang et al.   BRAIN RESEARCH

α-Synuclein and neuronal cell death

(2009) Mark R Cookson   Molecular Neurodegeneration

Additive Protective Effects of Donepezil and Nicotine Against Salsolinol-Induced Cytotoxicity in SH-SY5Y Cells

(2009) Jharna R. Das et al.   NEUROTOXICITY RESEARCH