Perillyl Alcohol Attenuates NLRP3 Inflammasome Activation and Rescues Dopaminergic Neurons in Experimental In Vitro and In Vivo Models of Parkinson’s Disease

Lipopolysaccharide exacerbates chronic restraint stress-induced neurobehavioral deficits: Mechanisms by redox imbalance, ASK1-related apoptosis, autophagic dysregulation

(2021) Mohit Kwatra et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Perillyl Alcohol Mitigates Behavioural Changes and Limits Cell Death and Mitochondrial Changes in Unilateral 6-OHDA Lesion Model of Parkinson’s Disease Through Alleviation of Oxidative Stress

(2020) Ehraz Anis et al.   NEUROTOXICITY RESEARCH

Andrographolide suppresses NLRP3 inflammasome activation in microglia through induction of parkin-mediated mitophagy in in-vitro and in-vivo models of Parkinson disease

(2020) Sahabuddin Ahmed et al.   BRAIN BEHAVIOR AND IMMUNITY

Potential role of TrkB agonist in neuronal survival by promoting CREB/BDNF and PI3K/Akt signaling in vitro and in vivo model of 3-nitropropionic acid (3-NP)-induced neuronal death

(2020) Sahabuddin Ahmed et al.   APOPTOSIS

Melatonin Reduces NLRP3 Inflammasome Activation by Increasing α7 nAChR-Mediated Autophagic Flux

(2020) Víctor Farré-Alins et al.   Antioxidants

5-(3,4-Difluorophenyl)−3-(6-methylpyridin-3-yl)−1,2,4-oxadiazole (DDO-7263), a Novel Nrf2 Activator Targeting Brain Tissue, Protects Against MPTP-induced Subacute Parkinson's Disease in Mice by Inhibiting the NLRP3 Inflammasome and Protects PC12 Cells Against Oxidative Stress

(2019) Li-Li Xu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease

(2019) Xiaojuan Han et al.   Autophagy

Emerging views of mitophagy in immunity and autoimmune diseases

(2019) Ye Xu et al.   Autophagy

Docosahexaenoic Acid Increases the Potency of Soluble Epoxide Hydrolase Inhibitor in Alleviating Streptozotocin-Induced Alzheimer’s Disease-Like Complications of Diabetes

(2019) Rohit Pardeshi et al.   Frontiers in Pharmacology

MicroRNA-190 alleviates neuronal damage and inhibits neuroinflammation via Nlrp3 in MPTP-induced Parkinson's disease mouse model

(2019) Qiang Sun et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Melatonin Attenuates LPS-Induced Acute Depressive-Like Behaviors and Microglial NLRP3 Inflammasome Activation Through the SIRT1/Nrf2 Pathway

(2019) Burak I. Arioz et al.   Frontiers in Immunology

Targeting the microglial NLRP3 inflammasome and its role in Parkinson's disease

(2019) Md. Ezazul Haque et al.   MOVEMENT DISORDERS

PPARß/δ agonist alleviates NLRP3 inflammasome-mediated neuroinflammation in the MPTP mouse model of Parkinson’s disease

(2018) Linfang Chen et al.   BEHAVIOURAL BRAIN RESEARCH

Hydrogen sulfide attenuates oxidative stress-induced NLRP3 inflammasome activation via S-sulfhydrating c-Jun at Cys269 in macrophages

(2018) Zhe Lin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration

(2018) Eunju Lee et al.   CELL DEATH AND DIFFERENTIATION

Perillyl alcohol alleviates amyloid-β peptides-induced mitochondrial dysfunction and cytotoxicity in SH-SY5Y cells

(2018) Mohammad Faraz Zafeer et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Nyctanthes arbor-tristis leaf extract ameliorates hyperlipidemia- and hyperglycemia-associated nephrotoxicity by improving anti-oxidant and anti-inflammatory status in high-fat diet–streptozotocin-induced diabetic rats

(2018) Sayed Adam Mousum et al.   INFLAMMOPHARMACOLOGY

Evaluation of phytomedicinal potential of perillyl alcohol in an in vitro Parkinson's Disease model

(2018) Ehraz Anis et al.   DRUG DEVELOPMENT RESEARCH

Bidirectional Microglia–Neuron Communication in Health and Disease

(2018) Zsuzsanna Szepesi et al.   Frontiers in Cellular Neuroscience

Hydrogen peroxide-mediated oxidative stress induces inflammasome activation in term human placental explants

(2018) Priscila Rezeck Nunes et al.   Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health

TLR4 absence reduces neuroinflammation and inflammasome activation in Parkinson’s diseases in vivo model

(2018) Michela Campolo et al.   BRAIN BEHAVIOR AND IMMUNITY

Bavachin attenuates LPS-induced inflammatory response and inhibits the activation of NLRP3 inflammasome in macrophages

(2018) Yung-Li Hung et al.   PHYTOMEDICINE

Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

(2018) Richard Gordon et al.   Science Translational Medicine

Divergent Effects of Metformin on an Inflammatory Model of Parkinson’s Disease

(2018) Khadija Tayara et al.   Frontiers in Cellular Neuroscience

The mechanisms of NLRP3 inflammasome/pyroptosis activation and their role in Parkinson's disease

(2018) Shuo Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Mitochondria in the pathophysiology of Alzheimer s and Parkinson s diseases

(2017) Isaac G Onyango   Frontiers in Bioscience-Landmark

The NLRP3 Inflammasome is Involved in the Pathogenesis of Parkinson’s Disease in Rats

(2017) Zhijuan Mao et al.   NEUROCHEMICAL RESEARCH

The Role of Microglia in Retinal Neurodegeneration: Alzheimer's Disease, Parkinson, and Glaucoma

(2017) Ana I. Ramirez et al.   Frontiers in Aging Neuroscience

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

Cholesterol contributes to dopamine-neuronal loss in MPTP mouse model of Parkinson’s disease: Involvement of mitochondrial dysfunctions and oxidative stress

(2017) Rajib Paul et al.   PLoS One

Naringin and Sertraline Ameliorate Doxorubicin-Induced Behavioral Deficits Through Modulation of Serotonin Level and Mitochondrial Complexes Protection Pathway in Rat Hippocampus

(2016) Mohit Kwatra et al.   NEUROCHEMICAL RESEARCH

Perillyl alcohol improves functional and histological outcomes against ischemia–reperfusion injury by attenuation of oxidative stress and repression of COX-2, NOS-2 and NF-κB in middle cerebral artery occlusion rats

(2015) Rizwana Tabassum et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Even free radicals should follow some rules: A Guide to free radical research terminology and methodology

(2015) Henry Jay Forman et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress and Parkinson’s disease

(2015) Javier Blesa et al.   Frontiers in Neuroanatomy

Chronic TLR Stimulation Controls NLRP3 Inflammasome Activation through IL-10 Mediated Regulation of NLRP3 Expression and Caspase-8 Activation

(2015) Prajwal Gurung et al.   Scientific Reports

Microglia and neuronal cell death

(2012) José L. Marín-Teva et al.   Neuron Glia Biology

Mitochondria: Sovereign of inflammation?

(2011) Jürg Tschopp   EUROPEAN JOURNAL OF IMMUNOLOGY

Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations

(2011) Balaraman Kalyanaraman et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reduced calcium/calmodulin-dependent protein kinase II activity in the hippocampus is associated with impaired cognitive function in MPTP-treated mice

(2011) Shigeki Moriguchi et al.   JOURNAL OF NEUROCHEMISTRY

Neuroinflammation in Parkinson's disease

(2011) Etienne C. Hirsch et al.   PARKINSONISM & RELATED DISORDERS

Components of lemon essential oil attenuate dementia induced by scopolamine

(2009) Wenjun Zhou et al.   NUTRITIONAL NEUROSCIENCE