Toll-like receptor 4-mediated nuclear factor-κB activation in spinal cord contributes to chronic morphine-induced analgesic tolerance and hyperalgesia in rats

Opioid receptor–triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia

(2014) Ji-Tian Xu et al.   JOURNAL OF CLINICAL INVESTIGATION

Toll-Like Receptor 4 Signaling Contributes to Paclitaxel-Induced Peripheral Neuropathy

(2014) Yan Li et al.   JOURNAL OF PAIN

Morphine mediates a proinflammatory phenotype via μ-opioid receptor–PKCɛ–Akt–ERK1/2 signaling pathway in activated microglial cells

(2013) Stefania Merighi et al.   BIOCHEMICAL PHARMACOLOGY

EphrinB-EphB receptor signaling contributes to bone cancer pain via Toll-like receptor and proinflammatory cytokines in rat spinal cord

(2013) Su Liu et al.   PAIN

Opioid Regulation of Mu Receptor Internalisation: Relevance to the Development of Tolerance and Dependence

(2012) Juan F. Lopez-Gimenez et al.   CNS & Neurological Disorders-Drug Targets

Acute Morphine Activates Satellite Glial Cells and Up-Regulates IL-1β in Dorsal Root Ganglia in Mice via Matrix Metalloprotease-9

(2012) Temugin Berta et al.   Molecular Pain

Microglia: A Promising Target for Treating Neuropathic and Postoperative Pain, and Morphine Tolerance

(2011) Yeong-Ray Wen et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Opioid-Induced Hyperalgesia and Tolerance

(2010) Mary Hanna Bekhit   AMERICAN JOURNAL OF THERAPEUTICS

Inhibition of NF-kappaB prevents mechanical allodynia induced by spinal ventral root transection and suppresses the re-expression of Nav1.3 in DRG neurons in vivo and in vitro

(2010) Ying Zang et al.   BRAIN RESEARCH

Expression and distribution of mTOR, p70S6K, 4E-BP1, and their phosphorylated counterparts in rat dorsal root ganglion and spinal cord dorsal horn

(2010) Ji-Tain Xu et al.   BRAIN RESEARCH

The Effect of Morphine on Glial Cells as a Potential Therapeutic Target for Pharmacological Development of Analgesic Drugs

(2010) Haroon Hameed et al.   Current Pain and Headache Reports

Transgenic inhibition of glial NF-kappa B reduces pain behavior and inflammation after peripheral nerve injury

(2010) Eugene S. Fu et al.   PAIN

Evidence that opioids may have toll-like receptor 4 and MD-2 effects

(2009) Mark R. Hutchinson et al.   BRAIN BEHAVIOR AND IMMUNITY

NF- B in the Nervous System

(2009) B. Kaltschmidt et al.   Cold Spring Harbor Perspectives in Biology

Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia

(2008) Mark R. Hutchinson et al.   BRAIN BEHAVIOR AND IMMUNITY

The IKK-NF-κB pathway: a source for novel molecular drug targets in pain therapy?

(2008) Ellen Niederberger et al.   FASEB JOURNAL

TNF Alpha Production in Morphine-Treated Human Neural Cells Is NF-κB-Dependent

(2008) Bassel E. Sawaya et al.   Journal of Neuroimmune Pharmacology

Glia in pathological pain: A role for fractalkine

(2008) E.D. Milligan et al.   JOURNAL OF NEUROIMMUNOLOGY