Necroptosis Induced by Ruthenium(II) Complexes as Dual Catalytic Inhibitors of Topoisomerase I/II

Potent Inhibition of Thioredoxin Reductase by the Rh Derivatives of Anticancer M(arene/Cp*)(NHC)Cl2 Complexes

(2020) Dianna Truong et al.   INORGANIC CHEMISTRY

Rationally Designed Long-Wavelength Absorbing Ru(II) Polypyridyl Complexes as Photosensitizers for Photodynamic Therapy

(2020) Johannes Karges et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Long non-coding RNAs regulate drug resistance in cancer

(2020) Kaisheng Liu et al.   Molecular Cancer

Toward Multi-Targeted Platinum and Ruthenium Drugs—A New Paradigm in Cancer Drug Treatment Regimens?

(2019) Reece G. Kenny et al.   CHEMICAL REVIEWS

Discovery and Mechanistic Study of Tailor-Made Quinoline Derivatives as Topoisomerase 1 Poisons with Potent Anticancer Activity

(2019) Biswajit Kundu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Restraining Cancer Cells by Dual Metabolic Inhibition with a Mitochondrion-Targeted Platinum(II) Complex

(2019) Kun Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cisplatin-Induced Ototoxicity in Rats Is Driven by RIP3-Dependent Necroptosis

(2019) Choi et al.   Cells

New designs for phototherapeutic transition metal complexes

(2019) Peter J. Sadler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Photoactivated Lysosomal Escape of a Monofunctional PtII Complex Pt-BDPA for Nucleus Access

(2019) Xuling Xue et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A New Approach in Cancer Treatment: Discovery of Chlorido[N,N′-disalicylidene-1,2-phenylenediamine]iron(III) Complexes as Ferroptosis Inducers

(2019) Jessica Sagasser et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemistry and reactivity of ruthenium(II) complexes: DNA/protein binding mode and anticancer activity are related to the complex structure

(2019) Ana Rilak Simović et al.   COORDINATION CHEMISTRY REVIEWS

A view on drug resistance in cancer

(2019) Neil Vasan et al.   NATURE

An anticancer Os(II) bathophenanthroline complex as a human breast cancer stem cell-selective, mammosphere potent agent that kills cells by necroptosis

(2019) Vojtech Novohradsky et al.   Scientific Reports

A mitochondria-targeting hetero-binuclear Ir(iii)–Pt(ii) complex induces necrosis in cisplatin-resistant tumor cells

(2018) Cheng Ouyang et al.   CHEMICAL COMMUNICATIONS

Structure–activity relationships for ruthenium and osmium anticancer agents – towards clinical development

(2018) Samuel M. Meier-Menches et al.   CHEMICAL SOCIETY REVIEWS

A Bioactive l-Phenylalanine-Derived Arene in Multitargeted Organoruthenium Compounds: Impact on the Antiproliferative Activity and Mode of Action

(2018) Sanam Movassaghi et al.   INORGANIC CHEMISTRY

Oncosis-inducing cyclometalated iridium(iii) complexes

(2018) Ruilin Guan et al.   Chemical Science

Ruthenium coordination compounds of biological and biomedical significance. DNA binding agents

(2018) Viktor Brabec et al.   COORDINATION CHEMISTRY REVIEWS

Stimuli-Responsive Therapeutic Metallodrugs

(2018) Xiaohui Wang et al.   CHEMICAL REVIEWS

Metal Drugs and the Anticancer Immune Response

(2018) Bernhard Englinger et al.   CHEMICAL REVIEWS

In Vitro Anticancer Activity and in Vivo Biodistribution of Rhenium(I) Tricarbonyl Aqua Complexes

(2017) Kevin M. Knopf et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cytotoxic (salen)ruthenium(iii) anticancer complexes exhibit different modes of cell death directed by axial ligands

(2017) Cai Li et al.   Chemical Science

Necroptosis: an alternative cell death program defending against cancer

(2016) Dongshi Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Cancer therapy in the necroptosis era

(2016) Z Su et al.   CELL DEATH AND DIFFERENTIATION

Induction of Immunogenic Cell Death by Chemotherapeutic Platinum Complexes

(2015) Daniel Yuan Qiang Wong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design, synthesis and biological evaluation of novel 7-alkylamino substituted benzo[a]phenazin derivatives as dual topoisomerase I/II inhibitors

(2015) Bing-Lei Yao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Rhodium(I) N-Heterocyclic Carbene Bioorganometallics as in Vitro Antiproliferative Agents with Distinct Effects on Cellular Signaling

(2015) Luciano Oehninger et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Series of Novel Terpyridine-Skeleton Molecule Derivants Inhibit Tumor Growth and Metastasis by Targeting Topoisomerases

(2015) Han-Byeol Kwon et al.   JOURNAL OF MEDICINAL CHEMISTRY

Necroptosis-Inducing Rhenium(V) Oxo Complexes

(2015) Kogularamanan Suntharalingam et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Apoptosis, autophagy, necroptosis, and cancer metastasis

(2015) Zhenyi Su et al.   Molecular Cancer

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

Novel Selenosemicarbazone Metal Complexes Exert Anti-tumor Effect via Alternative, Caspase-independent Necroptotic Cell Death

(2015) Manja Zec et al.   Medicinal Chemistry

Poly(ADP-ribose): A signaling molecule in different paradigms of cell death

(2014) Francesca Aredia et al.   BIOCHEMICAL PHARMACOLOGY

Comparison Between Polypyridyl and Cyclometalated Ruthenium(II) Complexes: Anticancer Activities Against 2D and 3D Cancer Models

(2014) Huaiyi Huang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Organotin complexes containing carboxylate ligands with maleimide and naphthalimide derived partial structures: TrxR inhibition, cytotoxicity and activity in resistant cancer cells

(2014) Kely Navakoski de Oliveira et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Gold(III) Macrocycles: Nucleotide-Specific Unconventional Catalytic Inhibitors of Human Topoisomerase I

(2014) Kate J. Akerman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Necroptosis

(2014) Andreas Linkermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

TNF-induced necroptosis and PARP-1-mediated necrosis represent distinct routes to programmed necrotic cell death

(2013) Justyna Sosna et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Synthetic Methods for the Preparation of Platinum Anticancer Complexes

(2013) Justin J. Wilson et al.   CHEMICAL REVIEWS

Dual topoisomerase I and II poisoning by chiral Ru(II) complexes containing 2-thiophenylimidazo[4,5-f][1,10]phenanthroline derivatives

(2013) Yu-Chuan Wang et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Drugging Topoisomerases: Lessons and Challenges

(2012) Yves Pommier   ACS Chemical Biology

Contemporary Challenges in the Design of Topoisomerase II Inhibitors for Cancer Chemotherapy

(2012) Christian Bailly   CHEMICAL REVIEWS

Osmium(vi) nitrido complexes bearing azole heterocycles: a new class of antitumor agents

(2012) Wen-Xiu Ni et al.   Chemical Science

Two Novel Determinants of Etoposide Resistance in Small Cell Lung Cancer

(2011) M. H. Lawson et al.   CANCER RESEARCH

Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance

(2011) J.-P. Gillet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metal Complexes as Protein Kinase Inhibitors

(2010) Conrad Kunick et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Anti-Apoptotic Mechanisms of Drug Resistance in Cancer

(2009) T. Wilson et al.   CURRENT CANCER DRUG TARGETS

Platinum neurotoxicity pharmacogenetics

(2009) S. R. McWhinney et al.   MOLECULAR CANCER THERAPEUTICS