Sodium-Dependent Neutral Amino Acid Transporter 2 Can Serve as a Tertiary Carrier for l-Type Amino Acid Transporter 1-Utilizing Prodrugs

Structure and dynamics of the drug-bound bacterial transporter EmrE in lipid bilayers

(2021) Alexander A. Shcherbakov et al.   Nature Communications

Ganciclovir and Its Hemocompatible More Lipophilic Derivative Can Enhance the Apoptotic Effects of Methotrexate by Inhibiting Breast Cancer Resistance Protein (BCRP)

(2021) Magdalena Markowicz-Piasecka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

OPLS4: Improving Force Field Accuracy on Challenging Regimes of Chemical Space

(2021) Chao Lu et al.   Journal of Chemical Theory and Computation

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

An Overview of Cell-Based Assay Platforms for the Solute Carrier Family of Transporters

(2021) Vojtech Dvorak et al.   Frontiers in Pharmacology

Comparison of Experimental Strategies to Study l-Type Amino Acid Transporter 1 (LAT1) Utilization by Ligands

(2021) Johanna Huttunen et al.   MOLECULES

AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models

(2021) Mihaly Varadi et al.   NUCLEIC ACIDS RESEARCH

High- and Low-Affinity Transport in Plants From a Thermodynamic Point of View

(2020) Ingo Dreyer et al.   Frontiers in Plant Science

Functional Consequences of Low Activity of Transport System A for Neutral Amino Acids in Human Bone Marrow Mesenchymal Stem Cells

(2020) Martina Chiu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hitchhiking into the cell

(2020) Douglas B. Kell   Nature Chemical Biology

The RESOLUTE consortium: unlocking SLC transporters for drug discovery

(2020) Giulio Superti-Furga et al.   NATURE REVIEWS DRUG DISCOVERY

L-Type Amino Acid Transporter 1 Enables the Efficient Brain Delivery of Small-Sized Prodrug across the Blood–Brain Barrier and into Human and Mouse Brain Parenchymal Cells

(2020) Ahmed B. Montaser et al.   ACS Chemical Neuroscience

L-type amino acid transporter 1 utilizing prodrugs of ferulic acid revealed structural features supporting the design of prodrugs for brain delivery

(2019) Elena Puris et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Metabolic regulation of cell growth and proliferation

(2019) Jiajun Zhu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

L-Type amino acid transporter 1 (LAT1)-utilizing prodrugs are carrier-selective despite having low affinity for organic anion transporting polypeptides (OATPs)

(2019) Johanna Huttunen et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Membrane topology of rat sodium-coupled neutral amino acid transporter 2 (SNAT2)

(2018) Yudan Ge et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Structural properties for selective and efficient l -type amino acid transporter 1 (LAT1) mediated cellular uptake

(2018) Jussi Kärkkäinen et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Crystal structure of arginine-bound lysosomal transporter SLC38A9 in the cytosol-open state

(2018) Hsiang-Ting Lei et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structure of arginine-bound lysosomal transporter SLC38A9 in the cytosol-open state

(2018) Hsiang-Ting Lei et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Effects of Sodium and Amino Acid Substrate Availability upon the Expression and Stability of the SNAT2 (SLC38A2) Amino Acid Transporter

(2018) Thorsten M. Hoffmann et al.   Frontiers in Pharmacology

Targeted efflux transporter inhibitors – A solution to improve poor cellular accumulation of anti-cancer agents

(2018) Johanna Huttunen et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

L-type amino acid transporter 1 utilizing prodrugs: How to achieve effective brain delivery and low systemic exposure of drugs

(2017) Elena Puris et al.   JOURNAL OF CONTROLLED RELEASE

l -Type amino acid transporter 1 (lat1)-mediated targeted delivery of perforin inhibitors

(2016) Kristiina M. Huttunen et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Systemic and Brain Pharmacokinetics of Perforin Inhibitor Prodrugs

(2016) Mikko Gynther et al.   MOLECULAR PHARMACEUTICS

Amino Acid Promoieties Alter Valproic Acid Pharmacokinetics and Enable Extended Brain Exposure

(2016) Mikko Gynther et al.   NEUROCHEMICAL RESEARCH

A Call for Systematic Research on Solute Carriers

(2015) Adrián César-Razquin et al.   CELL

System A amino acid transporters regulate glutamine uptake and attenuate antibody-mediated arthritis

(2015) Bruno Raposo et al.   IMMUNOLOGY

Proteasomal Modulation of Cellular SNAT2 (SLC38A2) Abundance and Function by Unsaturated Fatty Acid Availability

(2015) Francesca Nardi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SLC transporters as therapeutic targets: emerging opportunities

(2015) Lawrence Lin et al.   NATURE REVIEWS DRUG DISCOVERY

LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation

(2015) Ruth Milkereit et al.   Nature Communications

The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity

(2014) Georg E Winter et al.   Nature Chemical Biology

Membrane transporters for the special amino acid glutamine: structure/function relationships and relevance to human health

(2014) Lorena Pochini et al.   Frontiers in Chemistry

Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects

(2013) Helgi B. Schiöth et al.   MOLECULAR ASPECTS OF MEDICINE

The SLC38 family of sodium–amino acid co-transporters

(2013) Stefan Bröer   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Design, Synthesis and Brain Uptake of LAT1-Targeted Amino Acid Prodrugs of Dopamine

(2013) Lauri Peura et al.   PHARMACEUTICAL RESEARCH

Investigation of the sodium-binding sites in the sodium-coupled betaine transporter BetP

(2012) K. Khafizov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conserved Tyrosine in the First Transmembrane Segment of Solute:Sodium Symporters Is Involved in Na+-coupled Substrate Co-transport

(2011) Sonia Mazier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Large Amino Acid Transporter 1 (LAT1) Prodrugs of Valproic Acid: New Prodrug Design Ideas for Central Nervous System Delivery

(2011) Lauri Peura et al.   MOLECULAR PHARMACEUTICS

Brain uptake of ketoprofen–lysine prodrug in rats

(2010) Mikko Gynther et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Towards the comprehensive, rapid, and accurate prediction of the favorable tautomeric states of drug-like molecules in aqueous solution

(2010) Jeremy R. Greenwood et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

SAT1, a glutamine transporter, is preferentially expressed in GABAergic neurons

(2010) Solbu   Frontiers in Neuroanatomy

Ion-Releasing State of a Secondary Membrane Transporter

(2009) Jing Li et al.   BIOPHYSICAL JOURNAL

SNAT2 Amino Acid Transporter Is Regulated by Amino Acids of the SLC6 γ-Aminobutyric Acid Transporter Subfamily in Neocortical Neurons and May Play No Role in Delivering Glutamine for Glutamatergic Transmission

(2009) Sukhjeevan Grewal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Conserved Na+Binding Site of the Sodium-coupled Neutral Amino Acid Transporter 2 (SNAT2)

(2009) Zhou Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Highly Conserved Asparagine 82 Controls the Interaction of Na+with the Sodium-coupled Neutral Amino Acid Transporter SNAT2

(2008) Zhou Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Engineering Protein Allostery: 1.05 Å Resolution Structure and Enzymatic Properties of a Na+-activated Trypsin

(2008) Michael J. Page et al.   JOURNAL OF MOLECULAR BIOLOGY

The Evolutionary History and Tissue Mapping of Amino Acid Transporters Belonging to Solute Carrier Families SLC32, SLC36, and SLC38

(2008) Björn E. Sundberg et al.   JOURNAL OF MOLECULAR NEUROSCIENCE