Ketamine's schizophrenia-like effects are prevented by targeting PTP1B

Neuronal Protein Tyrosine Phosphatase 1B Hastens Amyloid β-Associated Alzheimer's Disease in Mice

(2020) Konrad M. Ricke et al.   JOURNAL OF NEUROSCIENCE

Hyperactivated PTP1B phosphatase in parvalbumin neurons alters anterior cingulate inhibitory circuits and induces autism-like behaviors

(2020) Li Zhang et al.   Nature Communications

Ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines

(2020) Farhan Ali et al.   Nature Communications

On the Origins of Schizophrenia

(2020) René S. Kahn   AMERICAN JOURNAL OF PSYCHIATRY

Activation of tyrosine phosphatase PTP1B in pyramidal neurons impairs endocannabinoid signaling by tyrosine receptor kinase trkB and causes schizophrenia-like behaviors in mice

(2020) Zhaohong Qin et al.   NEUROPSYCHOPHARMACOLOGY

Cocaine-induced endocannabinoid signaling mediated by sigma-1 receptors and extracellular vesicle secretion

(2019) Yoki Nakamura et al.   eLife

GABA interneurons are the cellular trigger for ketamine’s rapid antidepressant actions

(2019) Danielle M. Gerhard et al.   JOURNAL OF CLINICAL INVESTIGATION

Src is the primary target of aripiprazole, an atypical antipsychotic drug, in its anti-tumor action

(2017) Mi Seon Kim et al.   Oncotarget

NMDAR inhibition-independent antidepressant actions of ketamine metabolites

(2016) Panos Zanos et al.   NATURE

Dysregulation of the dopamine system in the pathophysiology of schizophrenia and depression

(2016) Anthony A. Grace   NATURE REVIEWS NEUROSCIENCE

Betaine enhances antidepressant-like, but blocks psychotomimetic effects of ketamine in mice

(2016) Jen-Cheng Lin et al.   PSYCHOPHARMACOLOGY

Reduced Prepulse Inhibition as a Biomarker of Schizophrenia

(2016) Auxiliadora Mena et al.   Frontiers in Behavioral Neuroscience

Knockout of NMDA-receptors from parvalbumin interneurons sensitizes to schizophrenia-related deficits induced by MK-801

(2016) A M Bygrave et al.   Translational Psychiatry

Functional properties of Claramine: A novel PTP1B inhibitor and insulin-mimetic compound

(2015) Zhaohong Qin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pyramidal Cell Selective Ablation of N-Methyl-D-Aspartate Receptor 1 Causes Increase in Cellular and Network Excitability

(2015) Valerie M. Tatard-Leitman et al.   BIOLOGICAL PSYCHIATRY

Active endocannabinoids are secreted on extracellular membrane vesicles

(2015) M. Gabrielli et al.   EMBO REPORTS

Chronic Stress Induces Anxiety via an Amygdalar Intracellular Cascade that Impairs Endocannabinoid Signaling

(2015) Zhaohong Qin et al.   NEURON

Differential Pharmacological Regulation of Sensorimotor Gating Deficit in CB1 Knockout Mice and Associated Neurochemical and Histological Alterations

(2015) Antonio Ortega-Álvaro et al.   NEUROPSYCHOPHARMACOLOGY

Alpha-lipoic acid alone and combined with clozapine reverses schizophrenia-like symptoms induced by ketamine in mice: Participation of antioxidant, nitrergic and neurotrophic mechanisms

(2015) Germana Silva Vasconcelos et al.   SCHIZOPHRENIA RESEARCH

Morphological and behavioral evidence for impaired prefrontal cortical function in female CB1 receptor deficient mice

(2014) Tiffany T.-Y. Lee et al.   BEHAVIOURAL BRAIN RESEARCH

Ketamine Administration During the Second Postnatal Week Alters Synaptic Properties of Fast-Spiking Interneurons in the Medial Prefrontal Cortex of Adult Mice

(2014) Vivek Jeevakumar et al.   CEREBRAL CORTEX

Protein-tyrosine Phosphatase 1B (PTP1B) Is a Novel Regulator of Central Brain-derived Neurotrophic Factor and Tropomyosin Receptor Kinase B (TrkB) Signaling

(2014) Ceren Ozek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LMO4 Is Essential for Paraventricular Hypothalamic Neuronal Activity and Calcium Channel Expression to Prevent Hyperphagia

(2014) T. Zaman et al.   JOURNAL OF NEUROSCIENCE

Therapeutic Potential of Inhibitors of Endocannabinoid Degradation for the Treatment of Stress-Related Hyperalgesia in an Animal Model of Chronic Pain

(2014) Ermelinda Lomazzo et al.   NEUROPSYCHOPHARMACOLOGY

Neuronal representation of working memory in the medial prefrontal cortex of rats

(2014) Sheng-Tao Yang et al.   Molecular Brain

Ketamine-induced antidepressant effects are associated with AMPA receptors-mediated upregulation of mTOR and BDNF in rat hippocampus and prefrontal cortex

(2013) W. Zhou et al.   EUROPEAN PSYCHIATRY

The LIM Domain Only 4 Protein Is a Metabolic Responsive Inhibitor of Protein Tyrosine Phosphatase 1B That Controls Hypothalamic Leptin Signaling

(2013) N. R. Pandey et al.   JOURNAL OF NEUROSCIENCE

Prevention and reversal of ketamine-induced schizophrenia related behavior by minocycline in mice: Possible involvement of antioxidant and nitrergic pathways

(2013) Aline Santos Monte et al.   JOURNAL OF PSYCHOPHARMACOLOGY

NMDA Receptors Subserve Persistent Neuronal Firing during Working Memory in Dorsolateral Prefrontal Cortex

(2013) Min Wang et al.   NEURON

Contribution of NMDA Receptor Hypofunction in Prefrontal and Cortical Excitatory Neurons to Schizophrenia-Like Phenotypes

(2013) Gregory R. Rompala et al.   PLoS One

Endocannabinoid metabolism in the prefrontal cortex in schizophrenia

(2013) David W. Volk et al.   SCHIZOPHRENIA RESEARCH

Endoplasmic reticulum stress and the on site function of resident PTP1B

(2012) Doina Popov   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Chronic blockade of CB1receptors reverses startle gating deficits and associated neurochemical alterations in rats reared in isolation

(2012) E Zamberletti et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cortical circuit dysfunction and cognitive deficits in schizophrenia - implications for preemptive interventions

(2012) David A. Lewis   EUROPEAN JOURNAL OF NEUROSCIENCE

LIM Domain Only 4 (LMO4) Regulates Calcium-Induced Calcium Release and Synaptic Plasticity in the Hippocampus

(2012) Z. Qin et al.   JOURNAL OF NEUROSCIENCE

Target-Specific Expression of Presynaptic NMDA Receptors in Neocortical Microcircuits

(2012) Katherine A. Buchanan et al.   NEURON

Reversible Disruption of Pre-Pulse Inhibition in Hypomorphic-Inducible and Reversible CB1-/- Mice

(2012) Maria Franca Marongiu et al.   PLoS One

Protein Tyrosine Phosphatase PTP1B Is Involved in Hippocampal Synapse Formation and Learning

(2012) Federico Fuentes et al.   PLoS One

NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia

(2012) A. Anticevic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutamate Receptor Subtypes Mediating Synaptic Activation of Prefrontal Cortex Neurons: Relevance for Schizophrenia

(2011) D. C. Rotaru et al.   JOURNAL OF NEUROSCIENCE

Glycine Transporter Inhibitor Attenuates the Psychotomimetic Effects of Ketamine in Healthy Males: Preliminary Evidence

(2011) Deepak Cyril D'Souza et al.   NEUROPSYCHOPHARMACOLOGY

Presynaptic NMDA Receptors Mediate IPSC Potentiation at GABAergic Synapses in Developing Rat Neocortex

(2011) Seena S. Mathew et al.   PLoS One

Static and Dynamic Cognitive Deficits in Childhood Preceding Adult Schizophrenia: A 30-Year Study

(2010) Abraham Reichenberg et al.   AMERICAN JOURNAL OF PSYCHIATRY

Acute treatment with cannabinoid receptor agonist WIN55212.2 improves prepulse inhibition in psychosocially stressed mice

(2010) Magdalena M. Brzózka et al.   BEHAVIOURAL BRAIN RESEARCH

BDNF Evokes Release of Endogenous Cannabinoids at Layer 2/3 Inhibitory Synapses in the Neocortex

(2010) Fouad Lemtiri-Chlieh et al.   JOURNAL OF NEUROPHYSIOLOGY

A new partnership

(2010) Katie Kingwell   NATURE REVIEWS NEUROSCIENCE

Activation of Src by Protein Tyrosine Phosphatase 1B Is Required for ErbB2 Transformation of Human Breast Epithelial Cells

(2009) L. E. Arias-Romero et al.   CANCER RESEARCH

Endocannabinoid-Mediated Control of Synaptic Transmission

(2009) Masanobu Kano et al.   PHYSIOLOGICAL REVIEWS

Deficits in spatial memory correlate with modified  -aminobutyric acid type A receptor tyrosine phosphorylation in the hippocampus

(2009) V. Tretter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cannabinoid CB1 receptor antagonist rimonabant attenuates reinstatement of ketamine conditioned place preference in rats

(2008) Fangqiong Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Interleukin-6 Mediates the Increase in NADPH-Oxidase in the Ketamine Model of Schizophrenia

(2008) M. M. Behrens et al.   JOURNAL OF NEUROSCIENCE

Subchronic and chronic PCP treatment produces temporally distinct deficits in attentional set shifting and prepulse inhibition in rats

(2008) Alice Egerton et al.   PSYCHOPHARMACOLOGY