Establishment of hyperoxic cell culture system for predicting drug-induced liver injury: reducing accumulated lipids in hepatocytes derived from chimeric mice with humanized liver

Hypoxia‐inducible factor 2α drives hepatosteatosis through the fatty acid translocase CD36

(2020) Esther Rey et al.   LIVER INTERNATIONAL

Successful energy shift from glycolysis to mitochondrial oxidative phosphorylation in freshly isolated hepatocytes from humanized mice liver

(2020) Yugo Ikeyama et al.   TOXICOLOGY IN VITRO

Culture density contributes to hepatic functions of fresh human hepatocytes isolated from chimeric mice with humanized livers: Novel, long-term, functional two-dimensional in vitro tool for developing new drugs

(2020) Chihiro Yamasaki et al.   PLoS One

Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations

(2019) Wiebke Albrecht et al.   ARCHIVES OF TOXICOLOGY

Advances in Hypoxia-Inducible Factor Biology

(2018) Hani Choudhry et al.   Cell Metabolism

Human hepatic 3D spheroids as a model for steatosis and insulin resistance

(2018) Mikael Kozyra et al.   Scientific Reports

Control of oxygen tension recapitulates zone-specific functions in human liver microphysiology systems

(2017) Felipe T Lee-Montiel et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Combining Chimeric Mice with Humanized Liver, Mass Spectrometry, and Physiologically-Based Pharmacokinetic Modeling in Toxicology

(2016) Hiroshi Yamazaki et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Advantageous use of HepaRG cells for the screening and mechanistic study of drug-induced steatosis

(2016) Laia Tolosa et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Assessment of mitochondrial dysfunction-related, drug-induced hepatotoxicity in primary rat hepatocytes

(2016) Cong Liu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Generation of Novel Chimeric Mice with Humanized Livers by Using Hemizygous cDNA-uPA/SCID Mice

(2015) Chise Tateno et al.   PLoS One

HIF-1α and HIF-2α are critically involved in hypoxia-induced lipid accumulation in hepatocytes through reducing PGC-1α-mediated fatty acid β-oxidation

(2014) Yanlong Liu et al.   TOXICOLOGY LETTERS

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

(2013) Patricio Godoy et al.   ARCHIVES OF TOXICOLOGY

Exploratory toxicology as an integrated part of drug discovery. Part I: Why and how

(2013) Jorrit J. Hornberg et al.   DRUG DISCOVERY TODAY

Hepatic histological findings in suspected drug-induced liver injury: Systematic evaluation and clinical associations

(2013) David E. Kleiner et al.   HEPATOLOGY

Chimeric mice with a humanized liver as an animal model of troglitazone-induced liver injury

(2012) Masakazu Kakuni et al.   TOXICOLOGY LETTERS

Growth Hormone-Dependent Pathogenesis of Human Hepatic Steatosis in a Novel Mouse Model Bearing a Human Hepatocyte-Repopulated Liver

(2011) Chise Tateno et al.   ENDOCRINOLOGY

The rate of oxygen utilization by cells

(2011) Brett A. Wagner et al.   FREE RADICAL BIOLOGY AND MEDICINE