Radiotherapy-Triggered Proteolysis Targeting Chimera Prodrug Activation in Tumors

Rational Design for Nitroreductase (NTR)-Responsive Proteolysis Targeting Chimeras (PROTACs) Selectively Targeting Tumor Tissues

(2022) Shi Shi et al.   JOURNAL OF MEDICINAL CHEMISTRY

PROTAC targeted protein degraders: the past is prologue

(2022) Miklós Békés et al.   NATURE REVIEWS DRUG DISCOVERY

Radiotherapy Reduces N-Oxides for Prodrug Activation in Tumors

(2022) Zexuan Ding et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Proteolysis-targeting chimeras (PROTACs) in cancer therapy

(2022) Xinyi Li et al.   Molecular Cancer

Radiotherapy‐Induced Cleavage of Quaternary Ammonium Groups Activates Prodrugs in Tumors

(2022) Zhibin Guo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Radiation Cleaved Drug-Conjugate Linkers Enable Local Payload Release

(2022) Jeremy M. Quintana et al.   BIOCONJUGATE CHEMISTRY

Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1

(2021) Adam D. Cotton et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cancer Selective Target Degradation by Folate-Caged PROTACs

(2021) Jing Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Semiconducting polymer nano-PROTACs for activatable photo-immunometabolic cancer therapy

(2021) Chi Zhang et al.   Nature Communications

Aptamer‐PROTAC Conjugates (APCs) for Tumor‐Specific Targeting in Breast Cancer

(2021) Shipeng He et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Switching on prodrugs using radiotherapy

(2021) Jin Geng et al.   Nature Chemistry

Magnetic resonance linear accelerator technology and adaptive radiation therapy: An overview for clinicians

(2021) William A. Hall et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Radiotherapy as a tool to elicit clinically actionable signalling pathways in cancer

(2021) Giulia Petroni et al.   Nature Reviews Clinical Oncology

Proteolysis‐targeting chimeras in drug development: A safety perspective

(2020) Kevin Moreau et al.   BRITISH JOURNAL OF PHARMACOLOGY

Optical Control of Small Molecule-Induced Protein Degradation

(2020) Yuta Naro et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Light-induced control of protein destruction by opto-PROTAC

(2020) Jing Liu et al.   Science Advances

PHOTACs enable optical control of protein degradation

(2020) Martin Reynders et al.   Science Advances

Azo-PROTAC: Novel Light-Controlled Small-Molecule Tool for Protein Knockdown

(2020) Yu-Hui Jin et al.   JOURNAL OF MEDICINAL CHEMISTRY

External Radiation–Induced Local Hydroxylation Enables Remote Release of Functional Molecules in Tumors

(2020) Qunfeng Fu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Activity of BET-proteolysis targeting chimeric (PROTAC) compounds in triple negative breast cancer

(2019) María del Mar Noblejas-López et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Light-Induced Protein Degradation with Photocaged PROTACs

(2019) Gang Xue et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeted protein degradation: expanding the toolbox

(2019) Matthieu Schapira et al.   NATURE REVIEWS DRUG DISCOVERY

Prostate cancer–associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4

(2017) Xiangpeng Dai et al.   NATURE MEDICINE

PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer

(2016) Kanak Raina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phthalimide conjugation as a strategy for in vivo target protein degradation

(2015) G. E. Winter et al.   SCIENCE

Self-Immolative Linkers Literally Bridge Disulfide Chemistry and the Realm of Thiol-Free Drugs

(2015) Camilla Frich Riber et al.   Advanced Healthcare Materials

Disulfide-Cleavage-Triggered Chemosensors and Their Biological Applications

(2013) Min Hee Lee et al.   CHEMICAL REVIEWS

Reductive activation of 5-fluorodeoxyuridine prodrug possessing azide methyl group by hypoxic X-irradiation

(2011) Kazuhito Tanabe et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

(2009) Teresa A. Soucy et al.   NATURE

Prodrugs: design and clinical applications

(2008) Jarkko Rautio et al.   NATURE REVIEWS DRUG DISCOVERY