Self-Immolative Linkers Literally Bridge Disulfide Chemistry and the Realm of Thiol-Free Drugs

An oral redox-sensitive self-immolating prodrug strategy

(2015) Tao Sun et al.   CHEMICAL COMMUNICATIONS

Reduction and pH dual-bioresponsive crosslinked polymersomes for efficient intracellular delivery of proteins and potent induction of cancer cell apoptosis

(2014) Huanli Sun et al.   Acta Biomaterialia

Ring-Opening Polymerization of Prodrugs: A Versatile Approach to Prepare Well-Defined Drug-Loaded Nanoparticles

(2014) Jinyao Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An Activatable Theranostic for Targeted Cancer Therapy and Imaging

(2014) Sankarprasad Bhuniya et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Actively-targeted polyion complex micelles stabilized by cholesterol and disulfide cross-linking for systemic delivery of siRNA to solid tumors

(2014) Yusuke Oe et al.   BIOMATERIALS

Disulfide reshuffling triggers the release of a thiol-free anti-HIV agent to make up fast-acting, potent macromolecular prodrugs

(2014) Anders Kock et al.   CHEMICAL COMMUNICATIONS

Camptothecin prodrug block copolymer micelles with high drug loading and target specificity

(2014) Adnan R. Khan et al.   Polymer Chemistry

Highly Active Macromolecular Prodrugs Inhibit Expression of the Hepatitis C Virus Genome in the Host Cells

(2014) Pau Ruiz-Sanchis et al.   Advanced Healthcare Materials

Mutual prodrugs containing bio-cleavable and drug releasable disulfide linkers

(2013) Arun K. Jain et al.   BIOORGANIC CHEMISTRY

A fluorescence off–on reporter for real time monitoring of gemcitabine delivery to the cancer cells

(2013) Sankarprasad Bhuniya et al.   CHEMICAL COMMUNICATIONS

Disulfide-Cleavage-Triggered Chemosensors and Their Biological Applications

(2013) Min Hee Lee et al.   CHEMICAL REVIEWS

A hyaluronic acid–camptothecin nanoprodrug with cytosolic mode of activation for targeting cancer

(2013) Xia Yang et al.   Polymer Chemistry

Controlled Depolymerization: Stimuli-Responsive Self-Immolative Polymers

(2012) Gregory I. Peterson et al.   MACROMOLECULES

Trimethyl lock: a trigger for molecular release in chemistry, biology, and pharmacology

(2012) Michael N. Levine et al.   Chemical Science

A General Strategy To Construct Fluorogenic Probes from Charge-Generation Polymers (CGPs) and AIE-Active Fluorogens through Triggered Complexation

(2011) Changhua Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

pH and Reduction Dual-Bioresponsive Polymersomes for Efficient Intracellular Protein Delivery

(2011) Jinchao Zhang et al.   LANGMUIR

Poly(oligo-D-arginine) With Internal Disulfide Linkages as a Cytoplasm-sensitive Carrier for siRNA Delivery

(2010) Young-Wook Won et al.   MOLECULAR THERAPY

Self-immolative linkers in polymeric delivery systems

(2010) Christopher A. Blencowe et al.   Polymer Chemistry

Poly(Methacrylic Acid) Polymer Hydrogel Capsules: Drug Carriers, Sub-compartmentalized Microreactors, Artificial Organelles

(2010) Alexander N. Zelikin et al.   Small

Antitumor Efficacy of Colon-Specific HPMA Copolymer/9-Aminocamptothecin Conjugates in Mice Bearing Human-Colon Carcinoma Xenografts

(2009) Song-Qi Gao et al.   MACROMOLECULAR BIOSCIENCE

Prodrugs: design and clinical applications

(2008) Jarkko Rautio et al.   NATURE REVIEWS DRUG DISCOVERY

Overcoming multidrug resistance of small-molecule therapeutics through conjugation with releasable octaarginine transporters

(2008) E. A. Dubikovskaya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prodrug Strategies in Anticancer Chemotherapy

(2007) Felix Kratz et al.   ChemMedChem