Proteolysis‐targeting chimeras in drug development: A safety perspective
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Title
Proteolysis‐targeting chimeras in drug development: A safety perspective
Authors
Keywords
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Journal
BRITISH JOURNAL OF PHARMACOLOGY
Volume -, Issue -, Pages -
Publisher
Wiley
Online
2020-02-05
DOI
10.1111/bph.15014
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Note: Only part of the references are listed.- The PROTAC technology in drug development
- (2019) Yutian Zou et al. CELL BIOCHEMISTRY AND FUNCTION
- Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase
- (2019) Blake E. Smith et al. Nature Communications
- A Practical Review of Proteasome Pharmacology
- (2019) Tiffany A. Thibaudeau et al. PHARMACOLOGICAL REVIEWS
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- (2019) Megan Scudellari NATURE
- Proteolysis targeting chimeras (PROTACs) in ‘beyond rule-of-five’ chemical space: Recent progress and future challenges
- (2019) Scott D. Edmondson et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Targeted protein degradation: elements of PROTAC design
- (2019) Stacey-Lynn Paiva et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Development of Multifunctional Histone Deacetylase 6 Degraders with Potent Antimyeloma Activity
- (2019) Hao Wu et al. JOURNAL OF MEDICINAL CHEMISTRY
- BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design
- (2019) William Farnaby et al. Nature Chemical Biology
- The Antigen Processing and Presentation Machinery in Lymphatic Endothelial Cells
- (2019) Laura Santambrogio et al. Frontiers in Immunology
- Protein quality control in the secretory pathway
- (2019) Zhihao Sun et al. JOURNAL OF CELL BIOLOGY
- Simple Structural Modifications Converting a Bona Fide MDM2 PROTAC Degrader into a Molecular Glue Molecule: A Cautionary Tale in the Design of PROTAC Degraders
- (2019) Jiuling Yang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Insights into ubiquitin chain architecture using Ub-clipping
- (2019) Kirby N. Swatek et al. NATURE
- THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Catalytic receptors
- (2019) Stephen P H Alexander et al. BRITISH JOURNAL OF PHARMACOLOGY
- THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Introduction and Other Protein Targets
- (2019) Stephen P H Alexander et al. BRITISH JOURNAL OF PHARMACOLOGY
- THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Nuclear hormone receptors
- (2019) Stephen P H Alexander et al. BRITISH JOURNAL OF PHARMACOLOGY
- THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Enzymes
- (2019) Stephen P H Alexander et al. BRITISH JOURNAL OF PHARMACOLOGY
- p63 is a cereblon substrate involved in thalidomide teratogenicity
- (2019) Tomoko Asatsuma-Okumura et al. Nature Chemical Biology
- Targeted protein degradation: expanding the toolbox
- (2019) Matthieu Schapira et al. NATURE REVIEWS DRUG DISCOVERY
- Discovery of novel small molecule induced selective degradation of the bromodomain and extra-terminal (BET) bromodomain protein BRD4 and BRD2 with cellular potencies
- (2019) Fei Jiang et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex
- (2019) Dirksen E. Bussiere et al. Nature Chemical Biology
- A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity
- (2019) Sajid Khan et al. NATURE MEDICINE
- Translation Termination Factor GSPT1 Is a Phenotypically Relevant Off-Target of Heterobifunctional Phthalimide Degraders
- (2018) Mette Ishoey et al. ACS Chemical Biology
- Ubiquitination: Friend and foe in cancer
- (2018) Mohammed A. Mansour INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Delineating the role of cooperativity in the design of potent PROTACs for BTK
- (2018) Adelajda Zorba et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- SALL4 mediates teratogenicity as a thalidomide-dependent cereblon substrate
- (2018) Mary E. Matyskiela et al. Nature Chemical Biology
- Regulation of proteasome assembly and activity in health and disease
- (2018) Adrien Rousseau et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome
- (2018) Katherine A Donovan et al. eLife
- Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN
- (2018) Quinlan L. Sievers et al. SCIENCE
- Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders
- (2017) Scott J. Hughes et al. Essays in Biochemistry
- Protac-Induced Protein Degradation in Drug Discovery: Breaking the Rules or Just Making New Ones?
- (2017) Ian Churcher JOURNAL OF MEDICINAL CHEMISTRY
- Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation
- (2017) Calla M Olson et al. Nature Chemical Biology
- Selective degradation of splicing factor CAPERα by anticancer sulfonamides
- (2017) Taisuke Uehara et al. Nature Chemical Biology
- The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY
- (2017) Simon D Harding et al. NUCLEIC ACIDS RESEARCH
- Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15
- (2017) Ting Han et al. SCIENCE
- Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation
- (2017) Chiara Maniaci et al. Nature Communications
- Small-Molecule PROTACS: New Approaches to Protein Degradation
- (2016) Momar Toure et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Protein Knockdown Technology: Application of Ubiquitin Ligase to Cancer Therapy
- (2016) Nobumichi Ohoka et al. CURRENT CANCER DRUG TARGETS
- The Effect of F877L and T878A Mutations on Androgen Receptor Response to Enzalutamide
- (2016) Stefan Prekovic et al. MOLECULAR CANCER THERAPEUTICS
- A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase
- (2016) Mary E. Matyskiela et al. NATURE
- PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer
- (2016) Kanak Raina et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition
- (2016) Julianty Frost et al. Nature Communications
- A Perspective on the Kinetics of Covalent and Irreversible Inhibition
- (2016) John M. Strelow SLAS Discovery
- Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4
- (2015) Michael Zengerle et al. ACS Chemical Biology
- Prime time for PROTACs
- (2015) Raymond J Deshaies Nature Chemical Biology
- Catalytic in vivo protein knockdown by small-molecule PROTACs
- (2015) Daniel P Bondeson et al. Nature Chemical Biology
- Molecular mechanisms of activity and derepression of alternative lengthening of telomeres
- (2015) Hilda A Pickett et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Molecular mechanisms of activity and derepression of alternative lengthening of telomeres
- (2015) Hilda A Pickett et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- A Comprehensive Mathematical Model for Three-Body Binding Equilibria
- (2013) Eugene F. Douglass et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- The Ikaros gene family: Transcriptional regulators of hematopoiesis and immunity
- (2011) Liza B. John et al. MOLECULAR IMMUNOLOGY
- Isobaric protein and peptide quantification: perspectives and issues
- (2010) Achim Treumann et al. Expert Review of Proteomics
- Population pharmacokinetic and pharmacodynamic analysis to support treatment optimization of combination chemotherapy with indisulam and carboplatin
- (2008) Anthe S. Zandvliet et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
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