Microglial depletion exacerbates motor impairment and dopaminergic neuron loss in a 6-OHDA model of Parkinson's disease

Microglial phagocytosis of neurons in neurodegeneration, and its regulation

(2021) Claire A Butler et al.   JOURNAL OF NEUROCHEMISTRY

Reactive microglia enhance the transmission of exosomal alpha-synuclein via toll-like receptor 2

(2021) Yun Xia et al.   BRAIN

Partial depletion and repopulation of microglia have different effects in the acute MPTP mouse model of Parkinson’s disease

(2021) Qing Li et al.   CELL PROLIFERATION

Microglia control glutamatergic synapses in the adult mouse hippocampus

(2021) Bernadette Basilico et al.   GLIA

p38-TFEB pathways promote microglia activation through inhibiting CMA-mediated NLRP3 degradation in Parkinson's disease

(2021) Jialong Chen et al.   Journal of Neuroinflammation

Suppressor mutations in Mecp2-null mice implicate the DNA damage response in Rett syndrome pathology

(2020) Adebola Enikanolaiye et al.   GENOME RESEARCH

Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration

(2020) Insup Choi et al.   Nature Communications

To Kill a Microglia: A Case for CSF1R Inhibitors

(2020) Kim N. Green et al.   TRENDS IN IMMUNOLOGY

Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brain

(2020) Joshua D. Crapser et al.   EBioMedicine

Exosomes in Parkinson disease

(2020) Jennifer R. Pinnell et al.   JOURNAL OF NEUROCHEMISTRY

PHF2 histone demethylase prevents DNA damage and genome instability by controlling cell cycle progression of neural progenitors

(2019) Stella Pappa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of MicroRNAs in Parkinson’s Disease

(2019) Suh Yee Goh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model

(2019) Elizabeth Spangenberg et al.   Nature Communications

Pharmacological inhibition of CSF1R by GW2580 reduces microglial proliferation and is protective against neuroinflammation and dopaminergic neurodegeneration

(2019) Matthew L. Neal et al.   FASEB JOURNAL

MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration

(2018) Eunju Lee et al.   CELL DEATH AND DIFFERENTIATION

Depletion of microglia augments the dopaminergic neurotoxicity of MPTP

(2018) Xiaoxia Yang et al.   FASEB JOURNAL

Characterization of LAMP1-labeled nondegradative lysosomal and endocytic compartments in neurons

(2018) Xiu-Tang Cheng et al.   JOURNAL OF CELL BIOLOGY

Parkinson’s disease: what the model systems have taught us so far

(2018) Swagata Ghatak et al.   JOURNAL OF GENETICS

The Potential Role of Toll-Like Receptor 4 in Mediating Dopaminergic Cell Loss and Alpha-Synuclein Expression in the Acute MPTP Mouse Model of Parkinson’s Disease

(2018) Giuseppina Mariucci et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

TREM2 — a key player in microglial biology and Alzheimer disease

(2018) Tyler K. Ulland et al.   Nature Reviews Neurology

Microglial repopulation resolves inflammation and promotes brain recovery after injury

(2017) Rachel A. Rice et al.   GLIA

Depletion of microglia exacerbates postischemic inflammation and brain injury

(2017) Wei-Na Jin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Adenosine A1 and A2A Receptors in the Brain: Current Research and Their Role in Neurodegeneration

(2017) et al.   MOLECULES

Molecular genetics and cellular events of K-Ras-driven tumorigenesis

(2017) G G Jinesh et al.   ONCOGENE

Modeling Parkinson’s disease and treatment complications in rodents: Potentials and pitfalls of the current options

(2017) Veronica Francardo   BEHAVIOURAL BRAIN RESEARCH

Eliminating microglia in Alzheimer’s mice prevents neuronal loss without modulating amyloid-β pathology

(2016) Elizabeth E. Spangenberg et al.   BRAIN

Chronic granulomatous disease: Clinical, molecular, and therapeutic aspects

(2016) Maria Chiriaco et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson’s disease and dementia with Lewy bodies

(2015) Anne Stuendl et al.   BRAIN

How microglia kill neurons

(2015) Guy C. Brown et al.   BRAIN RESEARCH

Abrogation of adenosine A1 receptor signalling improves metabolic regulation in mice by modulating oxidative stress and inflammatory responses

(2015) Ting Yang et al.   DIABETOLOGIA

Elimination of Microglia Improves Functional Outcomes Following Extensive Neuronal Loss in the Hippocampus

(2015) R. A. Rice et al.   JOURNAL OF NEUROSCIENCE

MDS clinical diagnostic criteria for Parkinson's disease

(2015) Ronald B. Postuma et al.   MOVEMENT DISORDERS

The alpha secretase ADAM10: A metalloprotease with multiple functions in the brain

(2015) Paul Saftig et al.   PROGRESS IN NEUROBIOLOGY

Characterizing Newly Repopulated Microglia in the Adult Mouse: Impacts on Animal Behavior, Cell Morphology, and Neuroinflammation

(2015) Monica R. P. Elmore et al.   PLoS One

Microglial priming in neurodegenerative disease

(2014) V. Hugh Perry et al.   Nature Reviews Neurology

Oxidative brain damage in Mecp2-mutant murine models of Rett syndrome

(2014) Claudio De Felice et al.   NEUROBIOLOGY OF DISEASE

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

Transcriptomics of Post-Stroke Angiogenesis in the Aged Brain

(2014) Ana Maria Buga et al.   Frontiers in Aging Neuroscience

A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model

(2013) Isaac M. Chiu et al.   Cell Reports

The Classification of Microglial Activation Phenotypes on Neurodegeneration and Regeneration in Alzheimer’s Disease Brain

(2012) Megan M. Varnum et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Wild-type microglia arrest pathology in a mouse model of Rett syndrome

(2012) Noël C. Derecki et al.   NATURE

IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia

(2012) Yaming Wang et al.   NATURE IMMUNOLOGY

Sensorimotor assessment of the unilateral 6-hydroxydopamine mouse model of Parkinson's disease

(2011) Kelly E. Glajch et al.   BEHAVIOURAL BRAIN RESEARCH

A minor isoform of the human RNA polymerase II subunit hRPB11 (POLR2J) interacts with several components of the translation initiation factor eIF3

(2011) S. A. Proshkin et al.   BIOCHEMISTRY-MOSCOW

Loss of Mecp2 in Substantia Nigra Dopamine Neurons Compromises the Nigrostriatal Pathway

(2011) S. C. Gantz et al.   JOURNAL OF NEUROSCIENCE

Presenilin Is Necessary for Efficient Proteolysis through the Autophagy-Lysosome System in a  -Secretase-Independent Manner

(2011) K. M. Neely et al.   JOURNAL OF NEUROSCIENCE

Absence of Colony Stimulation Factor-1 Receptor Results in Loss of Microglia, Disrupted Brain Development and Olfactory Deficits

(2011) Bryna Erblich et al.   PLoS One

Dopamine in Motor Cortex Is Necessary for Skill Learning and Synaptic Plasticity

(2009) Katiuska Molina-Luna et al.   PLoS One

Loss of MeCP2 in aminergic neurons causes cell-autonomous defects in neurotransmitter synthesis and specific behavioral abnormalities

(2009) R. C. Samaco et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The 6-hydroxydopamine model: News from the past

(2008) Fabio Blandini et al.   PARKINSONISM & RELATED DISORDERS

Characterization of the striatal 6-OHDA model of Parkinson's disease in wild type and α-synuclein-deleted mice

(2007) Daniel Alvarez-Fischer et al.   EXPERIMENTAL NEUROLOGY