Molecular genetics and cellular events of K-Ras-driven tumorigenesis

KRASmutation coupled withp53loss is sufficient to induce ovarian carcinosarcomas in mice

(2017) Feng-Hsiang Tang et al.   INTERNATIONAL JOURNAL OF CANCER

MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

(2017) Rajesha Rupaimoole et al.   NATURE REVIEWS DRUG DISCOVERY

Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells

(2017) Lingyu Meng et al.   Nature Communications

CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers

(2017) Smruthi Vijayaraghavan et al.   Nature Communications

Surface PD-L1, E-cadherin, CD24, and VEGFR2 as markers of epithelial cancer stem cells associated with rapid tumorigenesis

(2017) Goodwin G. Jinesh et al.   Scientific Reports

Pim kinase isoforms: devils defending cancer cells from therapeutic and immune attacks

(2016) Goodwin G. Jinesh et al.   APOPTOSIS

Blebbishields and mitotic cells exhibit robust macropinocytosis

(2016) Goodwin G. Jinesh et al.   BIOFACTORS

Selective Targeting of the KRAS G12C Mutant: Kicking KRAS When It’s Down

(2016) G. Aaron Hobbs et al.   CANCER CELL

miR-1298 Inhibits Mutant KRAS-Driven Tumor Growth by Repressing FAK and LAMB3

(2016) Ying Zhou et al.   CANCER RESEARCH

Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation

(2016) Christopher J. Tape et al.   CELL

Blebbishield emergency program: an apoptotic route to cellular transformation

(2016) G G Jinesh et al.   CELL DEATH AND DIFFERENTIATION

AXL Inhibition Suppresses the DNA Damage Response and Sensitizes Cells to PARP Inhibition in Multiple Cancers

(2016) Kavitha Balaji et al.   MOLECULAR CANCER RESEARCH

Mutant Kras copy number defines metabolic reprogramming and therapeutic susceptibilities

(2016) Emma M. Kerr et al.   NATURE

Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design

(2016) Jonathan M. L. Ostrem et al.   NATURE REVIEWS DRUG DISCOVERY

T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer

(2016) Eric Tran et al.   NEW ENGLAND JOURNAL OF MEDICINE

miR-26a desensitizes non-small cell lung cancer cells to tyrosine kinase inhibitors by targeting PTPN13

(2016) Shudi Xu et al.   Oncotarget

Novel PKC-ζ to p47phox interaction is necessary for transformation from blebbishields

(2016) Goodwin G. Jinesh et al.   Scientific Reports

Deregulation of the miR-16-KRAS axis promotes colorectal cancer

(2016) Chaoying You et al.   Scientific Reports

Smac mimetic with TNF-  targets Pim-1 isoforms and reactive oxygen species production to abrogate transformation from blebbishields

(2015) G. G. Jinesh et al.   BIOCHEMICAL JOURNAL

Hsa-miR-1 suppresses breast cancer development by down-regulating K-ras and long non-coding RNA MALAT1

(2015) Ruilei Liu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

KRAS-G12C Mutation is Associated with Poor Outcome in Surgically Resected Lung Adenocarcinoma

(2015) Ernest Nadal et al.   Journal of Thoracic Oncology

Nrf2 facilitates repair of radiation induced DNA damage through homologous recombination repair pathway in a ROS independent manner in cancer cells

(2015) Sundarraj Jayakumar et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The noncoding RNAs SNORD50A and SNORD50B bind K-Ras and are recurrently deleted in human cancer

(2015) Zurab Siprashvili et al.   NATURE GENETICS

Gene expression analysis identifies global gene dosage sensitivity in cancer

(2015) Rudolf S N Fehrmann et al.   NATURE GENETICS

KRAS and aneusomy of chromosomes 4, 10 and 12 in colorectal carcinomas

(2015) Kristin Beyer et al.   PATHOLOGY RESEARCH AND PRACTICE

Phosphorylation of PCNA by EGFR inhibits mismatch repair and promotes misincorporation during DNA synthesis

(2015) Janice Ortega et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membrane-targeting motif

(2015) Frederick D. Tsai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

G12V and G12A KRAS mutations are associated with poor outcome in patients with metastatic colorectal cancer treated with bevacizumab

(2015) Ondrej Fiala et al.   TUMOR BIOLOGY

Amplification of Chromosome 8 Genes in Lung Cancer

(2015) Onur Baykara et al.   Journal of Cancer

Selective targeting of KRAS-Mutant cells by miR-126 through repression of multiple genes essential for the survival of KRAS-Mutant cells

(2015) Toshifumi Hara et al.   Oncotarget

Targeting components of the alternative NHEJ pathway sensitizes KRAS mutant leukemic cells to chemotherapy

(2014) P. S. Hahnel et al.   BLOOD

Oncogenic KRAS Confers Chemoresistance by Upregulating NRF2

(2014) S. Tao et al.   CANCER RESEARCH

Novel signaling axis for ROS generation during K-Ras-induced cellular transformation

(2014) M-T Park et al.   CELL DEATH AND DIFFERENTIATION

ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis

(2014) Y Shi et al.   CELL DEATH AND DIFFERENTIATION

Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth

(2014) Yuan Yin et al.   CELL RESEARCH

Telomere-Dependent Genomic Integrity: Evolution of the Fusion-Bridge-Breakage Cycle Concept

(2014) Purificacion Feijoo et al.   CURRENT PHARMACEUTICAL DESIGN

Oncogenic Ras influences the expression of multiple lncRNAs

(2014) Yojiro Kotake et al.   CYTOTECHNOLOGY

Long Noncoding RNA ANRIL Promotes Non-Small Cell Lung Cancer Cell Proliferation and Inhibits Apoptosis by Silencing KLF2 and P21 Expression

(2014) F.-q. Nie et al.   MOLECULAR CANCER THERAPEUTICS

H19 promotes pancreatic cancer metastasis by derepressing let-7’s suppression on its target HMGA2-mediated EMT

(2014) Chenchao Ma et al.   TUMOR BIOLOGY

Bladder Cancer Stem Cells: Biological and Therapeutic Perspectives

(2014) Goodwin G. et al.   Current Stem Cell Research & Therapy

Increased NQO1 but Not c-MET and Survivin Expression in Non-Small Cell Lung Carcinoma with KRAS Mutations

(2014) Ahmet Yilmaz et al.   International Journal of Environmental Research and Public Health

A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype

(2014) Ryan W Serra et al.   eLife

A CDK4/6 inhibitor enhances cytotoxicity of paclitaxel in lung adenocarcinoma cells harboring mutant KRAS as well as wild-type KRAS

(2013) Xiang-Hua Zhang et al.   CANCER BIOLOGY & THERAPY

Phosphorylation at Ser-181 of Oncogenic KRAS Is Required for Tumor Growth

(2013) C. Barcelo et al.   CANCER RESEARCH

Overexpressed let-7a inhibits glioma cell malignancy by directly targeting K-ras, independently of PTEN

(2013) X.-R. Wang et al.   NEURO-ONCOLOGY

Regulation of the Intrinsic Apoptosis Pathway by Reactive Oxygen Species

(2012) Chu-Chiao Wu et al.   ANTIOXIDANTS & REDOX SIGNALING

Epidermal growth factor receptor and K-Ras mutations and resistance of lung cancer to insulin-like growth factor 1 receptor tyrosine kinase inhibitors

(2012) Woo-Young Kim et al.   CANCER

EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis

(2012) Christine M. Ardito et al.   CANCER CELL

A Comprehensive Survey of Ras Mutations in Cancer

(2012) I. A. Prior et al.   CANCER RESEARCH

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

(2012) Haoqiang Ying et al.   CELL

Blebbishields, the emergency program for cancer stem cells: sphere formation and tumorigenesis after apoptosis

(2012) G G Jinesh et al.   CELL DEATH AND DIFFERENTIATION

Smac mimetic enables the anticancer action of BCG-stimulated neutrophils through TNF-α but not through TRAIL and FasL

(2012) Goodwin Jinesh G. et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Redirecting neutrophils against bladder cancer cells by BCG and Smac mimetic combination

(2012) Goodwin Jinesh G. et al.   OncoImmunology

Genome wide single cell analysis of chemotherapy resistant metastatic cells in a case of gastroesophageal adenocarcinoma

(2011) Geir Olav Hjortland et al.   BMC CANCER

MicroRNA-622 functions as a tumor suppressor by targeting K-Ras and enhancing the anticarcinogenic effect of resveratrol

(2011) Zhiyuan Han et al.   CARCINOGENESIS

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

Somatic KRAS mutations associated with a human nonmalignant syndrome of autoimmunity and abnormal leukocyte homeostasis

(2010) J. E. Niemela et al.   BLOOD

Modulation of K-Ras-Dependent Lung Tumorigenesis by MicroRNA-21

(2010) Mark E. Hatley et al.   CANCER CELL

The miR-217 microRNA functions as a potential tumor suppressor in pancreatic ductal adenocarcinoma by targeting KRAS

(2010) Wu-Gan Zhao et al.   CARCINOGENESIS

Oncogenic K-Ras Turns Death Receptors Into Metastasis-Promoting Receptors in Human and Mouse Colorectal Cancer Cells

(2010) Frederik J.H. Hoogwater et al.   GASTROENTEROLOGY

Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward pathway

(2010) O. A. Kent et al.   GENES & DEVELOPMENT

K-Ras4B phosphorylation at Ser181 is inhibited by calmodulin and modulates K-Ras activity and function

(2010) B Alvarez-Moya et al.   ONCOGENE

Deletion of p53 in human mammary epithelial cells causes chromosomal instability and altered therapeutic response

(2010) M B Weiss et al.   ONCOGENE

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bladder Cancer Stem Cells

(2010) Mai N. Tran et al.   Current Stem Cell Research & Therapy

The miR-18a* microRNA functions as a potential tumor suppressor by targeting on K-Ras

(2009) Wing Pui Tsang et al.   CARCINOGENESIS

An Epigenetic Switch Involving NF-κB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell Transformation

(2009) Dimitrios Iliopoulos et al.   CELL

K-ras mutation status correlates with the expression of VEGFR1, VEGFR2, and PDGFRα in colorectal cancer

(2009) Carl C. Schimanski et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Human bronchial epithelial cells malignantly transformed by hexavalent chromium exhibit an aneuploid phenotype but no microsatellite instability

(2009) C.F.D. Rodrigues et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Modulation of microRNA processing by p53

(2009) Hiroshi I. Suzuki et al.   NATURE

BAD: undertaker by night, candyman by day

(2009) N N Danial   ONCOGENE

A SNP in a let-7 microRNA Complementary Site in the KRAS 3' Untranslated Region Increases Non-Small Cell Lung Cancer Risk

(2008) L. J. Chin et al.   CANCER RESEARCH

Gene expression deregulation by KRAS G12D and G12V in a BRAF V600E context

(2008) Massimiliano Monticone et al.   Molecular Cancer