Mediation of PKM2-dependent glycolytic and non-glycolytic pathways by ENO2 in head and neck cancer development

PKM2 Modulation in Head and Neck Squamous Cell Carcinoma

(2022) Verena Boschert et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ATAD3A mediates activation of RAS-independent mitochondrial ERK1/2 signaling, favoring head and neck cancer development

(2022) Liwei Lang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

NEDD4L inhibits glycolysis and proliferation of cancer cells in oral squamous cell carcinoma by inducing ENO1 ubiquitination and degradation

(2022) Guangping Zhang et al.   CANCER BIOLOGY & THERAPY

The Quest to Eradicate HPV-Related Oropharyngeal Carcinoma: An Opportunity Not to Miss

(2022) Chloe S Lalonde et al.   JNCI-Journal of the National Cancer Institute

ENO1 and Cancer

(2022) Chen Kai Huang et al.   Molecular Therapy-Oncolytics

A Novel Enolase-1 Antibody Targets Multiple Interacting Players in the Tumor Microenvironment of Advanced Prostate Cancer

(2022) Mao-Lin Chen et al.   MOLECULAR CANCER THERAPEUTICS

Activator-Mediated Pyruvate Kinase M2 Activation Contributes to Endotoxin Tolerance by Promoting Mitochondrial Biogenesis

(2021) Zhujun Yi et al.   Frontiers in Immunology

Head and neck cancer

(2021) Mayur D Mody et al.   LANCET

Blockade of glutamine-dependent cell survival augments antitumor efficacy of CPI-613 in head and neck cancer

(2021) Liwei Lang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The Hidden Link of Exosomes to Head and Neck Cancer

(2021) Yong Teng et al.   Cancers

Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis

(2020) Kulsoom Zahra et al.   Frontiers in Oncology

Targeting Hypoxia-Driven Metabolic Reprogramming to Constrain Tumor Progression and Metastasis

(2020) Marisol Miranda-Galvis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Metabolic landscape of oral squamous cell carcinoma

(2020) Jéssica Gardone Vitório et al.   Metabolomics

Enolase 1 regulates stem cell-like properties in gastric cancer cells by stimulating glycolysis

(2020) Ting Yang et al.   Cell Death & Disease

Head and neck squamous cell carcinoma

(2020) Daniel E. Johnson et al.   Nature Reviews Disease Primers

Intracellular citrate accumulation by oxidized ATM-mediated metabolism reprogramming via PFKP and CS enhances hypoxic breast cancer cell invasion and metastasis

(2019) Meixi Peng et al.   Cell Death & Disease

ENO2 Promotes Cell Proliferation, Glycolysis, and Glucocorticoid-Resistance in Acute Lymphoblastic Leukemia

(2018) Cheng-cheng Liu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Autophagy blockade sensitizes human head and neck squamous cell carcinoma towards CYT997 through enhancing excessively high reactive oxygen species-induced apoptosis

(2018) Lixia Gao et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Pyruvate kinase M2 fuels multiple aspects of cancer cells: from cellular metabolism, transcriptional regulation to extracellular signaling

(2018) Ming-Chuan Hsu et al.   Molecular Cancer

Targeting the Warburg effect via LDHA inhibition engages ATF4 signaling for cancer cell survival

(2018) Gaurav Pathria et al.   EMBO JOURNAL

FGFR4 provides the conduit to facilitate FGF19 signaling in breast cancer progression

(2018) Xiangdong Zhao et al.   MOLECULAR CARCINOGENESIS

FGF19 amplification reveals an oncogenic dependency upon autocrine FGF19/FGFR4 signaling in head and neck squamous cell carcinoma

(2018) Lixia Gao et al.   ONCOGENE

ENOblock, a unique small molecule inhibitor of the non-glycolytic functions of enolase, alleviates the symptoms of type 2 diabetes

(2017) Haaglim Cho et al.   Scientific Reports

ENOblock Does Not Inhibit the Activity of the Glycolytic Enzyme Enolase

(2017) Nikunj Satani et al.   PLoS One

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

PKM2, cancer metabolism, and the road ahead

(2016) Talya L Dayton et al.   EMBO REPORTS

Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): an open-label, multicentre, phase 1b trial

(2016) Tanguy Y Seiwert et al.   LANCET ONCOLOGY

Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck

(2016) Robert L. Ferris et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

PKM2 and cancer: The function of PKM2 beyond glycolysis

(2016) GAOCHAO DONG et al.   Oncology Letters

IGF1 regulates PKM2 function through Akt phosphorylation

(2015) Barbara Salani et al.   CELL CYCLE

The Correlations Between MRI Perfusion, Diffusion Parameters, and 18F-FDG PET Metabolic Parameters in Primary Head-and-Neck Cancer

(2015) Miran Han et al.   MEDICINE

Pyruvate kinase: Function, regulation and role in cancer

(2015) William J. Israelsen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

PKM2 promotes glucose metabolism and cell growth in gliomas through a mechanism involving a let-7a/c-Myc/hnRNPA1 feedback loop

(2015) Wenkang Luan et al.   Oncotarget

High glucose uptake unexpectedly is accompanied by high levels of the mitochondrial β-F1-ATPase subunit in head and neck squamous cell carcinoma

(2015) Christian U. Huebbers et al.   Oncotarget

A Unique Small Molecule Inhibitor of Enolase Clarifies Its Role in Fundamental Biological Processes

(2013) Da-Woon Jung et al.   ACS Chemical Biology

PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis

(2012) Weiwei Yang et al.   CELL

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

(2012) Weiwei Yang et al.   NATURE CELL BIOLOGY

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

(2012) Dimitrios Anastasiou et al.   Nature Chemical Biology

Altered metabolism in head and neck squamous cell carcinoma: an opportunity for identification of novel biomarkers and drug targets

(2011) Vlad C. Sandulache et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

(2011) Weiwei Yang et al.   NATURE

Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2

(2011) J Chen et al.   ONCOGENE

EGF-Induced ERK Activation Promotes CK2-Mediated Disassociation of α-Catenin from β-Catenin and Transactivation of β-Catenin

(2009) Haitao Ji et al.   MOLECULAR CELL

Pyruvate kinase M2 is a phosphotyrosine-binding protein

(2008) Heather R. Christofk et al.   NATURE

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE