NEDD4L inhibits glycolysis and proliferation of cancer cells in oral squamous cell carcinoma by inducing ENO1 ubiquitination and degradation

CircKDM4B suppresses breast cancer progression via the miR-675/NEDD4L axis

(2022) Xiang-Yu Guo et al.   ONCOGENE

ENO1 Promotes Lung Cancer Metastasis via HGFR and WNT Signaling–Driven Epithelial-to-Mesenchymal Transition

(2021) Hsin-Jung Li et al.   CANCER RESEARCH

NEDD4L downregulates autophagy and cell growth by modulating ULK1 and a glutamine transporter

(2020) Dong-Eun Lee et al.   Cell Death & Disease

hsa_circ_0072387 Suppresses Proliferation, Metastasis, and Glycolysis of Oral Squamous Cell Carcinoma Cells by Downregulating miR-503-5p

(2020) Long Han et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Tanshinone IIA inhibits oral squamous cell carcinoma via reducing Akt-c-Myc signaling-mediated aerobic glycolysis

(2020) Ming Li et al.   Cell Death & Disease

The circ-AMOTL1/ENO1 Axis Implicated in the Tumorigenesis of OLP-Associated Oral Squamous Cell Carcinoma

(2020) Jin Liu et al.   Cancer Management and Research

Enolase 1 regulates stem cell-like properties in gastric cancer cells by stimulating glycolysis

(2020) Ting Yang et al.   Cell Death & Disease

STK35 Is Ubiquitinated by NEDD4L and Promotes Glycolysis and Inhibits Apoptosis Through Regulating the AKT Signaling Pathway, Influencing Chemoresistance of Colorectal Cancer

(2020) Haojun Yang et al.   Frontiers in Cell and Developmental Biology

When Place Matters: Shuttling of Enolase-1 Across Cellular Compartments

(2019) Miroslava Didiasova et al.   Frontiers in Cell and Developmental Biology

p21 in Cancer Research

(2019) Shamloo et al.   Cancers

STAT3 Promotes Invasion and Aerobic Glycolysis of Human Oral Squamous Cell Carcinoma via Inhibiting FoxO1

(2019) Min Zheng et al.   Frontiers in Oncology

NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor

(2019) Laura Novellasdemunt et al.   EMBO JOURNAL

Progress in targeted therapeutic drugs for oral squamous cell carcinoma

(2019) Lian Liu et al.   SURGICAL ONCOLOGY-OXFORD

Downregulation of Nedd4L predicts poor prognosis, promotes tumor growth and inhibits MAPK/ERK signal pathway in hepatocellular carcinoma

(2018) Fengbo Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ki-67: more than a proliferation marker

(2018) Xiaoming Sun et al.   CHROMOSOMA

The type 1 transmembrane glycoprotein B7-H3 interacts with the glycolytic enzyme ENO1 to promote malignancy and glycolysis in HeLa cells

(2018) Jiahui Zuo et al.   FEBS LETTERS

Neural precursor cell-expressed developmentally down-regulated 4-like: a new biomarker in the pathophysiology of endometrial cancer

(2018) Ercan Yilmaz et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

The miR-106b-25 cluster mediates breast tumor initiation through activation of NOTCH1 via direct repression of NEDD4L

(2018) A. L. Guarnieri et al.   ONCOGENE

Regulation of proliferation and cell cycle by protein regulator of cytokinesis 1 in oral squamous cell carcinoma

(2018) Fanglong Wu et al.   Cell Death & Disease

Salvanic acid B inhibits glycolysis in oral squamous cell carcinoma via targeting PI3K/AKT/HIF-1α signaling pathway

(2018) Jie Wei et al.   Cell Death & Disease

Alpha-enolase (ENO1) controls alpha v/beta 3 integrin expression and regulates pancreatic cancer adhesion, invasion, and metastasis

(2017) Moitza Principe et al.   Journal of Hematology & Oncology

The Glycolytic Switch in Tumors: How Many Players Are Involved?

(2017) Li Yu et al.   Journal of Cancer

NEDD4L Protein Catalyzes Ubiquitination of PIK3CA Protein and Regulates PI3K-AKT Signaling

(2016) Zixi Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NEDD4-2 (NEDD4L): The ubiquitin ligase for multiple membrane proteins

(2015) Pranay Goel et al.   GENE

Nedd4L expression is decreased in ovarian epithelial cancer tissues compared to ovarian non-cancer tissue

(2015) Qiuyun Yang et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH

NEDD4: A Promising Target for Cancer Therapy

(2014) Xiantao Ye et al.   CURRENT CANCER DRUG TARGETS

Alpha-enolase as a potential cancer prognostic marker promotes cell growth, migration, and invasion in glioma

(2014) Ye Song et al.   Molecular Cancer

Whole-Genome Sequencing of Individuals from a Founder Population Identifies Candidate Genes for Asthma

(2014) Catarina D. Campbell et al.   PLoS One

NEDD4 E3 ligase inhibits the activity of the Hippo pathway by targeting LATS1 for degradation

(2013) Zaidoun Salah et al.   CELL CYCLE

Tumor glycolysis as a target for cancer therapy: progress and prospects

(2013) Shanmugasundaram Ganapathy-Kanniappan et al.   Molecular Cancer

Deubiquitylation and stabilization of PTEN by USP13

(2013) Jinsong Zhang et al.   NATURE CELL BIOLOGY

Surface α-Enolase Promotes Extracellular Matrix Degradation and Tumor Metastasis and Represents a New Therapeutic Target

(2013) Kuan-Chung Hsiao et al.   PLoS One

NEDD4L Is Downregulated in Colorectal Cancer and Inhibits Canonical WNT Signaling

(2013) Jarred P. Tanksley et al.   PLoS One

Down-regulation of Nedd4L is Associated with the Aggressive Progression and Worse Prognosis of Malignant Glioma

(2012) S. He et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

A Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth In Vitro and In Vivo

(2012) Y. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Decreased expression of Nedd4L correlates with poor prognosis in gastric cancer patient

(2011) Chengcheng Gao et al.   MEDICAL ONCOLOGY

Is there a role for carbohydrate restriction in the treatment and prevention of cancer?

(2011) Rainer J Klement et al.   Nutrition & Metabolism

Identification of small molecule inhibitors of pyruvate kinase M2

(2009) Matthew G. Vander Heiden et al.   BIOCHEMICAL PHARMACOLOGY

Nedd4L expression is downregulated in prostate cancer compared to benign prostatic hyperplasia

(2008) X.Y. Hu et al.   EJSO

p21 and p27: roles in carcinogenesis and drug resistance

(2008) Abde M. Abukhdeir et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE