Regulation of Gene Expression by m6Am RNA Modification

Eukaryotic mRNA Decapping Activation

(2022) Elva Vidya et al.   Frontiers in Genetics

m6Am methyltransferase PCIF1 is essential for aggressiveness of gastric cancer cells by inhibiting TM9SF1 mRNA translation

(2022) Wei Zhuo et al.   Cell Discovery

Effects of the m6Am methyltransferase PCIF1 on cell proliferation and survival in gliomas

(2022) Shangfeng Gao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

2′-O-Methylation of the second transcribed nucleotide within the mRNA 5′ cap impacts the protein production level in a cell-specific manner and contributes to RNA immune evasion

(2022) Karolina Drazkowska et al.   NUCLEIC ACIDS RESEARCH

Structural insights into molecular mechanism for N6-adenosine methylation by MT-A70 family methyltransferase METTL4

(2022) Qiang Luo et al.   Nature Communications

FTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell

(2021) Sébastien Relier et al.   Nature Communications

m6Am-seq reveals the dynamic m6Am methylation in the human transcriptome

(2021) Hanxiao Sun et al.   Nature Communications

Dynamic regulation of N6,2′-O-dimethyladenosine (m6Am) in obesity

(2021) Moshe Shay Ben-Haim et al.   Nature Communications

A Pan-Cancer Analysis of the Oncogenic and Immunogenic Role of m6Am Methyltransferase PCIF1

(2021) Ming-Zhu Jin et al.   Frontiers in Oncology

METTL4 is an snRNA m6Am methyltransferase that regulates RNA splicing

(2020) Hao Chen et al.   CELL RESEARCH

The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5′ cap modulates protein expression in living cells

(2020) Pawel J Sikorski et al.   NUCLEIC ACIDS RESEARCH

N6-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA

(2020) Ziyang Hao et al.   MOLECULAR CELL

Regulation of Adipocyte Differentiation by METTL4, a 6 mA Methylase

(2020) Zhenxi Zhang et al.   Scientific Reports

FTO Demethylates Cyclin D1 mRNA and Controls Cell-Cycle Progression

(2020) Mayumi Hirayama et al.   Cell Reports

CG14906 (mettl4) mediates m6A methylation of U2 snRNA in Drosophila

(2020) Lei Gu et al.   Cell Discovery

METTL4 catalyzes m6Am methylation in U2 snRNA to regulate pre-mRNA splicing

(2020) Yeek Teck Goh et al.   NUCLEIC ACIDS RESEARCH

The Mammalian Cap-Specific m6Am RNA Methyltransferase PCIF1 Regulates Transcript Levels in Mouse Tissues

(2020) Radha Raman Pandey et al.   Cell Reports

Structural insights into FTO’s catalytic mechanism for the demethylation of multiple RNA substrates

(2019) Xiao Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FTO controls reversible m6Am RNA methylation during snRNA biogenesis

(2019) Jan Mauer et al.   Nature Chemical Biology

Identification of the m6Am Methyltransferase PCIF1 Reveals the Location and Functions of m6Am in the Transcriptome

(2019) Konstantinos Boulias et al.   MOLECULAR CELL

PCIF1 Catalyzes m6Am mRNA Methylation to Regulate Gene Expression

(2019) Erdem Sendinc et al.   MOLECULAR CELL

Reading, writing and erasing mRNA methylation

(2019) Sara Zaccara et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Quantifying the RNA cap epitranscriptome reveals novel caps in cellular and viral RNA

(2019) Jin Wang et al.   NUCLEIC ACIDS RESEARCH

Landscape and Regulation of m6A and m6Am Methylome across Human and Mouse Tissues

(2019) Jun’e Liu et al.   MOLECULAR CELL

Atlas of quantitative single-base-resolution N6-methyl-adenine methylomes

(2019) Casslynn W. Q. Koh et al.   Nature Communications

Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm

(2018) Jiangbo Wei et al.   MOLECULAR CELL

Cap-specific, terminal N6-methylation by a mammalian m6Am methyltransferase

(2018) Hanxiao Sun et al.   CELL RESEARCH

Cap-specific terminal N6-methylation of RNA by an RNA polymerase II–associated methyltransferase

(2018) Shinichiro Akichika et al.   SCIENCE

Thiol-linked alkylation of RNA to assess expression dynamics

(2017) Veronika A Herzog et al.   NATURE METHODS

Mass spectrometry of modified RNAs: recent developments

(2016) Collin Wetzel et al.   ANALYST

Reversible methylation of m6Am in the 5′ cap controls mRNA stability

(2016) Jan Mauer et al.   NATURE

Base-pair-resolution genome-wide mapping of active RNA polymerases using precision nuclear run-on (PRO-seq)

(2016) Dig Bijay Mahat et al.   Nature Protocols

mRNA capping: biological functions and applications

(2016) Anand Ramanathan et al.   NUCLEIC ACIDS RESEARCH

Patient Mutation Directed shRNA Screen Uncovers Novel Bladder Tumor Growth Suppressors

(2015) J. Hensel et al.   MOLECULAR CANCER RESEARCH

Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome

(2015) Bastian Linder et al.   NATURE METHODS

Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5′ Sites

(2014) Schraga Schwartz et al.   Cell Reports

A novel synthesis and detection method for cap-associated adenosine modifications in mouse mRNA

(2011) Susanne Kruse et al.   Scientific Reports

High-throughput functional screening for autophagy-related genes and identification ofTM9SF1as an autophagosome-inducing gene

(2009) Pengfei He et al.   Autophagy

Human phosphorylated CTD-interacting protein, PCIF1, negatively modulates gene expression by RNA polymerase II

(2008) Yutaka Hirose et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS