Discogenic Low Back Pain: Anatomy, Pathophysiology and Treatments of Intervertebral Disc Degeneration

Intervertebral Disc Degeneration: Biomaterials and Tissue Engineering Strategies toward Precision Medicine

(2022) Isma Liza Mohd Isa et al.   Advanced Healthcare Materials

Notochordal Cell-Based Treatment Strategies and Their Potential in Intervertebral Disc Regeneration

(2022) Frances C. Bach et al.   Frontiers in Cell and Developmental Biology

Disc Height Narrowing Could Not Stabilize the Mobility at the Level of Cervical Spondylolisthesis: A Retrospective Study of 83 Patients with Cervical Single-Level Spondylolisthesis

(2022) Ryoma Aoyama et al.   Asian Spine Journal

An Injectable Hyaluronic Acid Hydrogel Promotes Intervertebral Disc Repair in A Rabbit Model

(2021) Masahiro Inoue et al.   SPINE

Treatment Preferences for Chronic Low Back Pain: Views of Veterans and Their Providers

(2021) Ilana Belitskaya-Levy et al.   Journal of Pain Research

Cell-based strategies for IVD repair: clinical progress and translational obstacles

(2021) Abbie L. A. Binch et al.   Nature Reviews Rheumatology

Innervation of the human intervertebral disc: a scoping review

(2021) Adam M R Groh et al.   PAIN MEDICINE

3D virtual reconstruction and quantitative assessment of the human intervertebral disc’s annulus fibrosus: a DTI tractography study

(2021) Dan Stein et al.   Scientific Reports

Correlational analysis of chemokine and inflammatory cytokine expression in the intervertebral disc and blood in patients with lumbar disc disease

(2021) Akihiko Hiyama et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Lumbar Degenerative Disease Part 1: Anatomy and Pathophysiology of Intervertebral Discogenic Pain and Radiofrequency Ablation of Basivertebral and Sinuvertebral Nerve Treatment for Chronic Discogenic Back Pain: A Prospective Case Series and Review of Literature

(2020) Hyeun Sung Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intervertebral Disc Diseases PART 2: A Review of the Current Diagnostic and Treatment Strategies for Intervertebral Disc Disease

(2020) Pang Hung Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Global low back pain prevalence and years lived with disability from 1990 to 2017: estimates from the Global Burden of Disease Study 2017

(2020) Aimin Wu et al.   Annals of Translational Medicine

Characterization of the human intervertebral disc cartilage endplate at the molecular, cell, and tissue levels

(2020) Katherine Lakstins et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

The STarT Back stratified care model for nonspecific low back pain

(2020) James A. Hall et al.   PAIN

IVD progenitor cells: a new horizon for understanding disc homeostasis and repair

(2019) Feng-Juan Lyu et al.   Nature Reviews Rheumatology

Chondrocyte‐like nested cells in the aged intervertebral disc are late‐stage nucleus pulposus cells

(2019) Sarthak Mohanty et al.   AGING CELL

Nonviral Transfection With Brachyury Reprograms Human Intervertebral Disc Cells to a Pro‐Anabolic Anti‐Catabolic/Inflammatory Phenotype: A Proof of Concept Study

(2019) Shirley Tang et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Mechanobiology of annulus fibrosus and nucleus pulposus cells in intervertebral discs

(2019) Sara Molladavoodi et al.   CELL AND TISSUE RESEARCH

RNA sequencing identifies gene regulatory networks controlling extracellular matrix synthesis in intervertebral disk tissues

(2018) Scott M. Riester et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Implantation of hyaluronic acid hydrogel prevents the pain phenotype in a rat model of intervertebral disc injury

(2018) Isma Liza Mohd Isa et al.   Science Advances

Annulus fibrosus cell phenotypes in homeostasis and injury: implications for regenerative strategies

(2018) Olivia M. Torre et al.   Annals of the New York Academy of Sciences

Biomechanics of the human intervertebral disc: A review of testing techniques and results

(2017) N. Newell et al.   Journal of the Mechanical Behavior of Biomedical Materials

Notochordal and nucleus pulposus marker expression is maintained by sub-populations of adult human nucleus pulposus cells through aging and degeneration

(2017) Stephen M. Richardson et al.   Scientific Reports

Novel Immortal Cell Lines Support Cellular Heterogeneity in the Human Annulus Fibrosus

(2016) Guus G. H. van den Akker et al.   PLoS One

Hyaluronic Acid Based Hydrogels Attenuate Inflammatory Receptors and Neurotrophins in Interleukin-1β Induced Inflammation Model of Nucleus Pulposus Cells

(2015) Isma Liza Mohd Isa et al.   BIOMACROMOLECULES

Low Back Pain

(2015) Gregory A. Von Forell et al.   SPINE

Gene Expression Profiling Identifies Interferon Signalling Molecules and IGFBP3 in Human Degenerative Annulus Fibrosus

(2015) Zepur Kazezian et al.   Scientific Reports

Tumor Necrosis Factor-α– and Interleukin-1β–Dependent Matrix Metalloproteinase-3 Expression in Nucleus Pulposus Cells Requires Cooperative Signaling via Syndecan 4 and Mitogen-Activated Protein Kinase–NF-κB Axis

(2014) Xin Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

Evaluation of Pain Behavior and Calcitonin Gene-Related Peptide Immunoreactive Sensory Nerve Fibers in the Spinal Dorsal Horn After Sciatic Nerve Compression and Application of Nucleus Pulposus in Rats

(2014) Seiji Kimura et al.   SPINE

Evaluation of intervertebral disc cartilaginous endplate structure using magnetic resonance imaging

(2013) Sung M. Moon et al.   EUROPEAN SPINE JOURNAL

Role of cytokines in intervertebral disc degeneration: pain and disc content

(2013) Makarand V. Risbud et al.   Nature Reviews Rheumatology

A validated new histological classification for intervertebral disc degeneration

(2013) J.P.H.J. Rutges et al.   OSTEOARTHRITIS AND CARTILAGE

In search of nucleus pulposus-specific molecular markers

(2013) F. Lv et al.   RHEUMATOLOGY

Substance P Stimulates Production of Inflammatory Cytokines in Human Disc Cells

(2013) Christopher K. Kepler et al.   SPINE

Genetic polymorphisms associated with intervertebral disc degeneration

(2013) Jillian E. Mayer et al.   Spine Journal

Dynamic pressurization induces transition of notochordal cells to a mature phenotype while retaining production of important patterning ligands from development

(2013) Devina Purmessur et al.   ARTHRITIS RESEARCH & THERAPY

Degenerate Human Nucleus Pulposus Cells Promote Neurite Outgrowth in Neural Cells

(2012) Stephen M. Richardson et al.   PLoS One

Changes in the Molecular Phenotype of Nucleus Pulposus Cells with Intervertebral Disc Aging

(2012) Xinyan Tang et al.   PLoS One

Annulus Fissures Are Mechanically and Chemically Conducive to the Ingrowth of Nerves and Blood Vessels

(2012) Manos Stefanakis et al.   SPINE

Micromechanics of annulus–end plate integration in the intervertebral disc

(2012) Samantha A. Rodrigues et al.   Spine Journal

Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc

(2012) Daisuke Sakai et al.   Nature Communications

TNF-α and IL-1β Promote a Disintegrin-like and Metalloprotease with Thrombospondin Type I Motif-5-mediated Aggrecan Degradation through Syndecan-4 in Intervertebral Disc

(2011) Jianru Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Degenerative Magnetic Resonance Imaging Changes in Patients With Chronic Low Back Pain

(2011) Dean Chou et al.   SPINE

Intervertebral disc, sensory nerves and neurotrophins: who is who in discogenic pain?

(2010) José García-Cosamalón et al.   JOURNAL OF ANATOMY

Analysis of cell viability in intervertebral disc: Effect of endplate permeability on cell population

(2010) A. Shirazi-Adl et al.   JOURNAL OF BIOMECHANICS

The relationship between the Wnt/β-catenin and TGF-β/BMP signals in the intervertebral disc cell

(2010) Akihiko Hiyama et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Interleukin-1β induces angiogenesis and innervation in human intervertebral disc degeneration

(2010) Jae Man Lee et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Neuronal circuitry for pain processing in the dorsal horn

(2010) Andrew J. Todd   NATURE REVIEWS NEUROSCIENCE

The Association Between Obesity and Low Back Pain: A Meta-Analysis

(2009) Rahman Shiri et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

The Association between Smoking and Low Back Pain: A Meta-analysis

(2009) Rahman Shiri et al.   AMERICAN JOURNAL OF MEDICINE

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

Resolving discogenic pain

(2008) Kazuhisa Takahashi et al.   EUROPEAN SPINE JOURNAL

Fibrin promotes proliferation and matrix production of intervertebral disc cells cultured in three-dimensional poly(lactic-co-glycolic acid) scaffold

(2008) Munirah Sha'ban et al.   JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION

BDNF as a pain modulator

(2008) A MERIGHI et al.   PROGRESS IN NEUROBIOLOGY

Expression and regulation of neurotrophins in the nondegenerate and degenerate human intervertebral disc

(2008) Devina Purmessur et al.   ARTHRITIS RESEARCH & THERAPY

Intervertebral Disc: Anatomy-Physiology-Pathophysiology-Treatment

(2008) P. Prithvi Raj   Pain Practice