Demethyleneberberine blocked the maturation of IL-1β in inflammation by inhibiting TLR4-mitochondria signaling

Tacrolimus-binding protein FKBP8 directs myosin light chain kinase-dependent barrier regulation and is a potential therapeutic target in Crohn’s disease

(2022) Li Zuo et al.   GUT

Phytochemicals targeting Toll-like receptors 4 (TLR4) in inflammatory bowel disease

(2022) Wenbin Dai et al.   Chinese Medicine

Ulcerative colitis: an update

(2021) Jonathan P Segal et al.   CLINICAL MEDICINE

Therapeutic implications of inflammasome in inflammatory bowel disease

(2021) Vishal Khatri et al.   FASEB JOURNAL

Inflammasome Regulation: Therapeutic Potential for Inflammatory Bowel Disease

(2021) Qiuyun Xu et al.   MOLECULES

Gegen Qinlian decoction relieved DSS-induced ulcerative colitis in mice by modulating Th17/Treg cell homeostasis via suppressing IL-6/JAK2/STAT3 signaling

(2021) Yaxing Zhao et al.   PHYTOMEDICINE

Pharmacological Inhibition of the Nod-Like Receptor Family Pyrin Domain Containing 3 Inflammasome with MCC950

(2021) Sarah E. Corcoran et al.   PHARMACOLOGICAL REVIEWS

Demethyleneberberine attenuates concanavalin A-induced autoimmune hepatitis in mice through inhibition of NF-κB and MAPK signaling

(2020) Miao Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Gegen Qinlian decoction maintains colonic mucosal homeostasis in acute/chronic ulcerative colitis via bidirectionally modulating dysregulated Notch signaling

(2020) Yaxing Zhao et al.   PHYTOMEDICINE

mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury

(2020) Long Shuang Huang et al.   IMMUNITY

Quasi-Irreversible Inhibition of CYP2D6 by Berberine

(2020) Ha Gyeong Kim et al.   Pharmaceutics

Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Mitochondrial Damage and Inflammation by Stabilizing Mitochondrial DNA

(2020) Meng Zhao et al.   ACS Nano

Coptis chinensis Franch polysaccharides provide a dynamically regulation on intestinal microenvironment, based on the intestinal flora and mucosal immunity

(2020) Qingqing Chen et al.   JOURNAL OF ETHNOPHARMACOLOGY

Berberine and barberry (Berberis vulgaris ): A clinical review

(2019) Mohsen Imenshahidi et al.   PHYTOTHERAPY RESEARCH

New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD

(2019) Anaïs Larabi et al.   Autophagy

The non-euphoric phytocannabinoid cannabidivarin counteracts intestinal inflammation in mice and cytokine expression in biopsies from UC pediatric patients

(2019) E. Pagano et al.   PHARMACOLOGICAL RESEARCH

Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity

(2018) Dave Boucher et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Coptidis rhizoma and its main bioactive components: recent advances in chemical investigation, quality evaluation and pharmacological activity

(2018) Fan-Cheng Meng et al.   Chinese Medicine

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

(2018) Zhenyu Zhong et al.   NATURE

Inflammasomes in the gastrointestinal tract: infection, cancer and gut microbiota homeostasis

(2018) Si Ming Man   Nature Reviews Gastroenterology & Hepatology

Reconstruction of LPS Transfer Cascade Reveals Structural Determinants within LBP, CD14, and TLR4-MD2 for Efficient LPS Recognition and Transfer

(2017) Je-Kyung Ryu et al.   IMMUNITY

Targeted-mitochondria antioxidants therapeutic implications in inflammatory bowel disease

(2017) Abel Matondo et al.   JOURNAL OF DRUG TARGETING

Demethyleneberberine attenuates non-alcoholic fatty liver disease with activation of AMPK and inhibition of oxidative stress

(2016) Xiaoyan Qiang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Demethyleneberberine alleviates inflammatory bowel disease in mice through regulating NF-κB signaling and T-helper cell homeostasis

(2016) Ying-Ying Chen et al.   INFLAMMATION RESEARCH

Mitochondria in the Regulation of Innate and Adaptive Immunity

(2015) Samuel E. Weinberg et al.   IMMUNITY

Amorphous solid dispersion of berberine with absorption enhancer demonstrates a remarkable hypoglycemic effect via improving its bioavailability

(2014) Meng Zhaojie et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Coptis chinensis Franch. exhibits neuroprotective properties against oxidative stress in human neuroblastoma cells

(2014) Thomas Friedemann et al.   JOURNAL OF ETHNOPHARMACOLOGY

Isolation and Identification of Urinary Metabolites of Berberine in Rats and Humans

(2008) F. Qiu et al.   DRUG METABOLISM AND DISPOSITION

Stimulation of Toll-like receptor 3 and 4 induces interleukin-1β maturation by caspase-8

(2008) Jonathan Maelfait et al.   JOURNAL OF EXPERIMENTAL MEDICINE