Tacrolimus-binding protein FKBP8 directs myosin light chain kinase-dependent barrier regulation and is a potential therapeutic target in Crohn’s disease

Robust differentiation of human enteroendocrine cells from intestinal stem cells

(2022) Daniel Zeve et al.   Nature Communications

Current and potential future applications of human stem cell models in drug development

(2020) Mark Donowitz et al.   JOURNAL OF CLINICAL INVESTIGATION

Increased Intestinal Permeability is Associated with Later Development of Crohn’s Disease

(2020) Williams Turpin et al.   GASTROENTEROLOGY

Graft-versus-host disease propagation depends on increased intestinal epithelial tight junction permeability

(2019) Sam C. Nalle et al.   JOURNAL OF CLINICAL INVESTIGATION

Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis

(2019) W. Vallen Graham et al.   NATURE MEDICINE

FKBP8 protects the heart from hemodynamic stress by preventing the accumulation of misfolded proteins and endoplasmic reticulum-associated apoptosis in mice

(2018) Tomofumi Misaka et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The structure of FKBP38 in complex with the MEEVD tetratricopeptide binding-motif of Hsp90

(2017) Katie L. I. M. Blundell et al.   PLoS One

Inflammation and the Intestinal Barrier: Leukocyte–Epithelial Cell Interactions, Cell Junction Remodeling, and Mucosal Repair

(2016) Anny-Claude Luissint et al.   GASTROENTEROLOGY

Recipient NK cell inactivation and intestinal barrier loss are required for MHC-matched graft-versus-host disease

(2014) S. C. Nalle et al.   Science Translational Medicine

TNFR2 Activates MLCK-Dependent Tight Junction Dysregulation to Cause Apoptosis-Mediated Barrier Loss and Experimental Colitis

(2013) Liping Su et al.   GASTROENTEROLOGY

Ca2+/S100 proteins regulate HCV virus NS5A-FKBP8/FKBP38 interaction and HCV virus RNA replication

(2013) Joji Tani et al.   LIVER INTERNATIONAL

FK506 Binding Protein 8 Peptidylprolyl Isomerase Activity Manages a Late Stage of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Folding and Stability

(2012) Darren M. Hutt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardiac Myosin Light Chain Kinase Is Necessary for Myosin Regulatory Light Chain Phosphorylation and Cardiac Performancein Vivo

(2010) Peiguo Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epithelial Myosin Light Chain Kinase Activation Induces Mucosal Interleukin-13 Expression to Alter Tight Junction Ion Selectivity

(2010) Christopher R. Weber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caveolin-1–dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo

(2010) Amanda M. Marchiando et al.   JOURNAL OF CELL BIOLOGY

Physiology and Function of the Tight Junction

(2009) J. M. Anderson et al.   Cold Spring Harbor Perspectives in Biology

Cytokine regulation of tight junctions

(2008) Christopher T. Capaldo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Myosin Light Chain Kinase Is Central to Smooth Muscle Contraction and Required for Gastrointestinal Motility in Mice

(2008) Wei–Qi He et al.   GASTROENTEROLOGY

Targeted Epithelial Tight Junction Dysfunction Causes Immune Activation and Contributes to Development of Experimental Colitis

(2008) Liping Su et al.   GASTROENTEROLOGY

A Single-Amino-Acid Mutation in Hepatitis C Virus NS5A Disrupting FKBP8 Interaction Impairs Viral Replication

(2008) T. Okamoto et al.   JOURNAL OF VIROLOGY