Caspase-8 Promotes Pulmonary Hypertension by Activating Macrophage-Associated Inflammation and IL-1β (Interleukin 1β) Production

Interleukin-1 and the Inflammasome as Therapeutic Targets in Cardiovascular Disease

(2020) Antonio Abbate et al.   CIRCULATION RESEARCH

Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis

(2020) Bart Tummers et al.   IMMUNITY

Hypoxia-inducible factor signaling in pulmonary hypertension

(2020) Soni Savai Pullamsetti et al.   JOURNAL OF CLINICAL INVESTIGATION

Perivascular Inflammation in Pulmonary Arterial Hypertension

(2020) Yijie Hu et al.   Cells

Identification of Celastramycin as a Novel Therapeutic Agent for Pulmonary Arterial Hypertension

(2019) Ryo Kurosawa et al.   CIRCULATION RESEARCH

Interleukin-1 Receptor Antagonist Protects Newborn Mice Against Pulmonary Hypertension

(2019) Christine B. Bui et al.   Frontiers in Immunology

ADAMTS8 Promotes the Development of Pulmonary Arterial Hypertension and Right Ventricular Failure -A Possible Novel Therapeutic Target-

(2019) Junichi Omura et al.   CIRCULATION RESEARCH

Melatonin inhibits inflammasome-associated activation of endothelium and macrophages attenuating pulmonary arterial hypertension

(2019) Jingyuan Zhang et al.   CARDIOVASCULAR RESEARCH

Protective Role of Myelocytic Nitric Oxide Synthases against Hypoxic Pulmonary Hypertension in Mice

(2018) Takaaki Ogoshi et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Selenoprotein P Promotes the Development of Pulmonary Arterial Hypertension: A Possible Novel Therapeutic Target

(2018) Nobuhiro Kikuchi et al.   CIRCULATION

NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis

(2018) Alena Grebe et al.   CIRCULATION RESEARCH

Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity

(2018) Dave Boucher et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pulmonary arterial hypertension: pathogenesis and clinical management

(2018) Thenappan Thenappan et al.   BMJ-British Medical Journal

Pulmonary arterial hypertension: pathogenesis and clinical management

(2018) Thenappan Thenappan et al.   BMJ-British Medical Journal

New and Emerging Therapies for Pulmonary Arterial Hypertension

(2018) Edda Spiekerkoetter et al.   Annual Review of Medicine

Interleukin-1 (IL-1) Blockade Reduces Inflammation in Pulmonary Arterial Hypertension and Right Ventricular Failure: A Single-Arm, Open-Label, Phase IB/II Pilot Study

(2018) Cory R Trankle et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation

(2018) Cun-Jin Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Caspase-8: regulating life and death

(2017) Bart Tummers et al.   IMMUNOLOGICAL REVIEWS

Epidemiology and treatment of pulmonary arterial hypertension

(2017) Edmund M. T. Lau et al.   Nature Reviews Cardiology

Thrombin-Activatable Fibrinolysis Inhibitor in Chronic Thromboembolic Pulmonary HypertensionHighlights

(2016) Nobuhiro Yaoita et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Role of interleukin-1 receptor 1/MyD88 signalling in the development and progression of pulmonary hypertension

(2016) Aurélien Parpaleix et al.   EUROPEAN RESPIRATORY JOURNAL

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

(2016) Robin A. Aglietti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

MicroRNA-143 Activation Regulates Smooth Muscle and Endothelial Cell Crosstalk in Pulmonary Arterial HypertensionNovelty and Significance

(2015) Lin Deng et al.   CIRCULATION RESEARCH

Caspase-8 functions as a key mediator of inflammation and pro-IL-1β processing via both canonical and non-canonical pathways

(2015) Tom P. Monie et al.   IMMUNOLOGICAL REVIEWS

EP3 receptor deficiency attenuates pulmonary hypertension through suppression of Rho/TGF-β1 signaling

(2015) Ankang Lu et al.   JOURNAL OF CLINICAL INVESTIGATION

HMGB1 promotes the activation of NLRP3 and caspase-8 inflammasomes via NF-κB pathway in acute glaucoma

(2015) Wei Chi et al.   Journal of Neuroinflammation

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Cross Talk Between Vascular Smooth Muscle Cells and Monocytes Through Interleukin-1β/Interleukin-18 Signaling Promotes Vein Graft Thickening

(2014) Ping Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inflammation and Immunity in the Pathogenesis of Pulmonary Arterial Hypertension

(2014) Marlene Rabinovitch et al.   CIRCULATION RESEARCH

Release of Interleukin-1α or Interleukin-1β Depends on Mechanism of Cell Death

(2014) Hazel England et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes

(2014) P. Gurung et al.   JOURNAL OF IMMUNOLOGY

Epigallocatechin Gallate Attenuates Proliferation and Oxidative Stress in Human Vascular Smooth Muscle Cells Induced by Interleukin-1βvia Heme Oxygenase-1

(2014) Po-Len Liu et al.   MEDIATORS OF INFLAMMATION

Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension

(2014) Rajkumar Savai et al.   NATURE MEDICINE

Caspase-8 promotes NLRP1/NLRP3 inflammasome activation and IL-1  production in acute glaucoma

(2014) W. Chi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapamycin Reverses Pulmonary Artery Smooth Muscle Cell Proliferation in Pulmonary Hypertension

(2013) Amal Houssaini et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

More to life than death: molecular determinants of necroptotic and non-necroptotic RIP3 kinase signaling

(2013) Nufail Khan et al.   CURRENT OPINION IN IMMUNOLOGY

Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance

(2013) Agnieszka Kaczmarek et al.   IMMUNITY

Proapoptotic Chemotherapeutic Drugs Induce Noncanonical Processing and Release of IL-1  via Caspase-8 in Dendritic Cells

(2013) C. Antonopoulos et al.   JOURNAL OF IMMUNOLOGY

Immune and Inflammatory Cell Involvement in the Pathology of Idiopathic Pulmonary Arterial Hypertension

(2012) Rajkumar Savai et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: FAS (CD95) Mediates Noncanonical IL-1  and IL-18 Maturation via Caspase-8 in an RIP3-Independent Manner

(2012) L. Bossaller et al.   JOURNAL OF IMMUNOLOGY

Caspases and immunity in a deadly grip

(2012) Ian G. Rodrigue-Gervais et al.   TRENDS IN IMMUNOLOGY

Caspase signalling controls microglia activation and neurotoxicity

(2011) Miguel A. Burguillos et al.   NATURE

Mechanisms of disease: pulmonary arterial hypertension

(2011) Ralph T. Schermuly et al.   Nature Reviews Cardiology

Estrogens and Development of Pulmonary Hypertension: Interaction of Estradiol Metabolism and Pulmonary Vascular Disease

(2010) Stevan P Tofovic   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

Stimulation of Toll-like receptor 3 and 4 induces interleukin-1β maturation by caspase-8

(2008) Jonathan Maelfait et al.   JOURNAL OF EXPERIMENTAL MEDICINE