Intrauterine Growth Restriction Programs Intergenerational Transmission of Pulmonary Arterial Hypertension and Endothelial Dysfunction via Sperm Epigenetic Modifications

Increased Expression of MicroRNA‐206 Inhibits Potassium Voltage‐Gated Channel Subfamily A Member 5 in Pulmonary Arterial Smooth Muscle Cells and Is Related to Exaggerated Pulmonary Artery Hypertension Following Intrauterine Growth Retardation in Rats

(2019) Ying Lv et al.   Journal of the American Heart Association

Sperm-inherited H3K27me3 impacts offspring transcription and development in C. elegans

(2019) Kiyomi Raye Kaneshiro et al.   Nature Communications

Notch3 signaling activation in smooth muscle cells promotes extrauterine growth restriction-induced pulmonary hypertension

(2019) Yu Wang et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Chronic Estrogen Supplementation Prevents the Increase in Blood Pressure in Female Intrauterine Growth-Restricted Offspring at 12 Months of Age

(2019) Gwendolyn K. Davis et al.   HYPERTENSION

Isolation and culture of rat aortic endothelial cells in vitro: A novel approach without collagenase digestion

(2019) Xiao‐Xiao Zhu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Endothelial and Smooth Muscle Cell Interaction via FoxM1 Signaling Mediates Vascular Remodeling and Pulmonary Hypertension

(2018) Zhiyu Dai et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Early life experience drives structural variation of neural genomes in mice

(2018) Tracy A. Bedrosian et al.   SCIENCE

Pulmonary arterial hypertension: pathogenesis and clinical management

(2018) Thenappan Thenappan et al.   BMJ-British Medical Journal

Pulmonary arterial hypertension: pathogenesis and clinical management

(2018) Thenappan Thenappan et al.   BMJ-British Medical Journal

Epigenetic Regulation and Its Therapeutic Potential in Pulmonary Hypertension

(2018) Yu Wang et al.   Frontiers in Pharmacology

Arginine bioavailability and endothelin-1 system in the regulation of vascular function of umbilical vein endothelial cells from intrauterine growth restricted newborns

(2018) Q. He et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Epigenetic Transgenerational Inheritance of Altered Sperm Histone Retention Sites

(2018) Millissia Ben Maamar et al.   Scientific Reports

Intergenerational and transgenerational epigenetic inheritance in animals

(2018) Marcos Francisco Perez et al.   NATURE CELL BIOLOGY

Three-Month Endothelial Human Endothelin-1 Overexpression Causes Blood Pressure Elevation and Vascular and Kidney InjuryNovelty and Significance

(2017) Suellen C. Coelho et al.   HYPERTENSION

The expression of endothelin-1 in chronic lymphocytic leukemia is controlled by epigenetic mechanisms and extracellular stimuli

(2017) Silvia Martinelli et al.   LEUKEMIA RESEARCH

Notch1 signalling regulates endothelial proliferation and apoptosis in pulmonary arterial hypertension

(2016) Swati Dabral et al.   EUROPEAN RESPIRATORY JOURNAL

Inheritance of Cytosine Methylation

(2016) Desiree Tillo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Intergenerational Transfer of Epigenetic Information in Sperm

(2016) Oliver J. Rando   Cold Spring Harbor Perspectives in Medicine

Targeted activation of endothelin-1 exacerbates hypoxia-induced pulmonary hypertension

(2015) Muhammad Gahan Satwiko et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Vascular Endothelium: Functioning in Norm, Changes in Atherosclerosis and Current Dietary Approaches to Improve Endothelial Function

(2015) Dimitry Chistiakov et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Molecular insights into transgenerational non-genetic inheritance of acquired behaviours

(2015) Johannes Bohacek et al.   NATURE REVIEWS GENETICS

Disruption of histone methylation in developing sperm impairs offspring health transgenerationally

(2015) K. Siklenka et al.   SCIENCE

Paternal low protein diet affects adult offspring cardiovascular and metabolic function in mice

(2014) Adam J. Watkins et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Paternal Diet Defines Offspring Chromatin State and Intergenerational Obesity

(2014) Anita Öst et al.   CELL

In Utero Undernutrition in Male Mice Programs Liver Lipid Metabolism in the Second-Generation Offspring Involving Altered Lxra DNA Methylation

(2014) Débora Martínez et al.   Cell Metabolism

You are what your grandmother ate—inherited effects of in utero undernourishment

(2014) Jennifer Sargent   Nature Reviews Endocrinology

In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism

(2014) E. J. Radford et al.   SCIENCE

First trimester fetal growth restriction and cardiovascular risk factors in school age children: population based cohort study

(2014) V. W. V. Jaddoe et al.   BMJ-British Medical Journal

Decreased Kv1.5 expression in intrauterine growth retardation rats with exaggerated pulmonary hypertension

(2013) Ying Lv et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Regulation of Hypoxia-induced Pulmonary Hypertension by Vascular Smooth Muscle Hypoxia-Inducible Factor-1α

(2013) Molly K. Ball et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Intergenerational programming of metabolic disease: evidence from human populations and experimental animal models

(2013) Mary-Elizabeth Patti   CELLULAR AND MOLECULAR LIFE SCIENCES

Prenatal Hypoxia Causes Long-Term Alterations in Vascular Endothelin-1 Function in Aged Male, but Not Female, Offspring

(2013) Stephane L. Bourque et al.   HYPERTENSION

Genome-wide chromatin analysis in mature mouse and human spermatozoa

(2013) Mizue Hisano et al.   Nature Protocols

Epigenetics of hypoxic pulmonary arterial hypertension following intrauterine growth retardation rat: epigenetics in PAH following IUGR

(2013) Xue-Feng Xu et al.   RESPIRATORY RESEARCH

Catch up growth in low birth weight infants: Striking a healthy balance

(2012) Vandana Jain et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Mechanisms of disease: pulmonary arterial hypertension

(2011) Ralph T. Schermuly et al.   Nature Reviews Cardiology

Endothelin-1 gene regulation

(2010) Lisa R. Stow et al.   FASEB JOURNAL

Epigenetic regulation of the endothelial nitric oxide synthase gene in persistent pulmonary hypertension of the newborn rat

(2010) Xue-Feng Xu et al.   JOURNAL OF HYPERTENSION

High Altitude, A Natural Research Laboratory for the Study of Cardiovascular Physiology and Pathophysiology

(2010) Urs Scherrer et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Intergenerational programming of impaired nephrogenesis and hypertension in rats following maternal protein restriction during pregnancy

(2008) Matthew Harrison et al.   BRITISH JOURNAL OF NUTRITION

Intergenerational Transmission of Glucose Intolerance and Obesity by In Utero Undernutrition in Mice

(2008) J. C. Jimenez-Chillaron et al.   DIABETES

Shared Constitutional Risks for Maternal Vascular-Related Pregnancy Complications and Future Cardiovascular Disease

(2008) Anne L. Berends et al.   HYPERTENSION

Isolation of endothelial cells from fresh tissues

(2008) Judy R van Beijnum et al.   Nature Protocols