Engineering lactate-modulating nanomedicines for cancer therapy

Self-Delivery Ternary Bioregulators for Photodynamic Amplified Immunotherapy by Tumor Microenvironment Reprogramming

(2022) Lin-Ping Zhao et al.   ACS Nano

Synergetic lethal energy depletion initiated by cancer cell membrane camouflaged nano-inhibitor for cancer therapy

(2022) Fudan Dong et al.   Nano Research

Microbiotic nanomedicine for tumor-specific chemotherapy-synergized innate/adaptive antitumor immunity

(2022) Wencheng Wu et al.   Nano Today

A Sub-6 nm MnFe2O4-dichloroacetic acid nanocomposite modulates tumor metabolism and catabolism for reversing tumor immunosuppressive microenvironment and boosting immunotherapy

(2022) Zan Dai et al.   BIOMATERIALS

Zinc-enriched nanosystem for dual glycolysis regulation and photothermal therapy to synergistically inhibit primary melanoma and lung metastasis

(2022) Zhaoxu Meng et al.   CHEMICAL ENGINEERING JOURNAL

Phase II study of dichloroacetate, an inhibitor of pyruvate dehydrogenase, in combination with chemoradiotherapy for unresected, locally advanced head and neck squamous cell carcinoma

(2022) Steven F. Powell et al.   INVESTIGATIONAL NEW DRUGS

Localized NIR-II laser mediated chemodynamic therapy of glioblastoma

(2022) Yuanbo Pan et al.   Nano Today

An acid degradable, lactate oxidizing nanoparticle formulation for non-small cell lung cancer virotherapy

(2022) S.-Ja Tseng et al.   Nano Today

Recent Advances in Nanomaterial‐Based Nanoplatforms for Chemodynamic Cancer Therapy

(2021) Shu‐Lan Li et al.   ADVANCED FUNCTIONAL MATERIALS

Monotherapy and Combination Therapy Using Anti‐Angiogenic Nanoagents to Fight Cancer

(2021) Pingping Liang et al.   ADVANCED MATERIALS

An Acidity‐Unlocked Nanoplatform Enables Self‐Boosting ROS Generation through Upregulation of Lactate for Highly Specific Chemodynamic Therapy

(2021) Linan Shi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Metabolic support of tumour-infiltrating regulatory T cells by lactic acid

(2021) McLane J. Watson et al.   NATURE

Lactate Metabolism and Signaling in Tuberculosis and Cancer: A Comparative Review

(2021) Dilara Kiran et al.   Frontiers in Cellular and Infection Microbiology

Zwitterion‐based hydrogen sulfide nanomotors induce multiple acidosis in tumor cells by destroying tumor metabolic symbiosis

(2021) Mimi Wan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tumor‐Targeted Disruption of Lactate Transport with Reactivity‐Reversible Nanocatalysts to Amplify Oxidative Damage

(2021) Xuan Wang et al.   Small

Potential therapeutics using tumor-secreted lactate in nonsmall cell lung cancer

(2021) Zi-Xian Liao et al.   DRUG DISCOVERY TODAY

Activatable Biomineralized Nanoplatform Remodels the Intracellular Environment of Multidrug‐Resistant Tumors for Enhanced Ferroptosis/Apoptosis Therapy

(2021) Xuan Wang et al.   Small

Peroxisome inspired hybrid enzyme nanogels for chemodynamic and photodynamic therapy

(2021) Xing Qin et al.   Nature Communications

Lactate Consumption via Cascaded Enzymes Combined VEGF siRNA for Synergistic Anti‐Proliferation and Anti‐Angiogenesis Therapy of Tumors

(2021) Yan Tang et al.   Advanced Healthcare Materials

Advanced Cancer Starvation Therapy by Simultaneous Deprivation of Lactate and Glucose Using a MOF Nanoplatform

(2021) Jiantao Yu et al.   Advanced Science

Harnessing Lactate Metabolism for Radiosensitization

(2021) Kevin X. Liu et al.   Frontiers in Oncology

A Self-Driven Bioreactor Based on Bacterium–Metal–Organic Framework Biohybrids for Boosting Chemotherapy via Cyclic Lactate Catabolism

(2021) Jia-Wei Wang et al.   ACS Nano

Metal-Phenolic Network-Enabled Lactic Acid Consumption Reverses Immunosuppressive Tumor Microenvironment for Sonodynamic Therapy

(2021) Zhan Zhang et al.   ACS Nano

Targeting lactate metabolism and glycolytic pathways in the tumor microenvironment by natural products: A promising strategy in combating cancer

(2021) Leila Kooshki et al.   BIOFACTORS

A biomimetic ZIF nanoagent for synergistic regulation of glutamine metabolism and intracellular acidosis of cancer

(2021) Mengzhen Wang et al.   CHEMICAL COMMUNICATIONS

Reinforcing vascular normalization therapy with a bi-directional nano-system to achieve therapeutic-friendly tumor microenvironment

(2021) Yudi Deng et al.   JOURNAL OF CONTROLLED RELEASE

Yeast@MOF bioreactor as a tumor metabolic symbiosis disruptor for the potent inhibition of metabolically heterogeneous tumors

(2021) Wenjie Wang et al.   Nano Today

Transport function, regulation, and biology of human monocarboxylate transporter 1 (hMCT1) and 4 (hMCT4)

(2021) Masaki Kobayashi et al.   PHARMACOLOGY & THERAPEUTICS

Nanofactory for metabolic and chemodynamic therapy: pro-tumor lactate trapping and anti-tumor ROS transition

(2021) Ruiqing He et al.   JOURNAL OF NANOBIOTECHNOLOGY

Dual‐Depletion of Intratumoral Lactate and ATP with Radicals Generation for Cascade Metabolic‐Chemodynamic Therapy

(2021) Feng Tian et al.   Advanced Science

Lactate in the tumour microenvironment: From immune modulation to therapy

(2021) Zi-Hao Wang et al.   EBioMedicine

Porphyrin-Based Metal-Organic Frameworks for Biomedical Applications

(2020) Yufang Zhu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The lactate receptor GPR81 promotes breast cancer growth via a paracrine mechanism involving antigen-presenting cells in the tumor microenvironment

(2020) Timothy P. Brown et al.   ONCOGENE

Harnessing nanomedicine to overcome the immunosuppressive tumor microenvironment

(2020) Bo Sun et al.   ACTA PHARMACOLOGICA SINICA

Jet‐Lagged Nanoparticles Enhanced Immunotherapy Efficiency through Synergistic Reconstruction of Tumor Microenvironment and Normalized Tumor Vasculature

(2020) Zhijie Jiang et al.   Advanced Healthcare Materials

Metabolic Modulation of the Tumor Microenvironment Leads to Multiple Checkpoint Inhibition and Immune Cell Infiltration

(2020) David Kolb et al.   ACS Nano

Physical triggering strategies for drug delivery

(2020) Tao Sun et al.   ADVANCED DRUG DELIVERY REVIEWS

Intervening Tumor Progression by Coupling Bacteria Respiration with Tumor Metabolism

(2020) Qi-Wen Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Openwork@Dendritic Mesoporous Silica Nanoparticles for Lactate Depletion and Tumor Microenvironment Regulation

(2020) Jie Tang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Engineering of Cascade-Responsive Nanoplatform to Inhibit Lactate Efflux for Enhanced Tumor Chemo-Immunotherapy

(2020) Ke Li et al.   ACS Nano

Nanoparticle-mediated delivery of 2-deoxy-D-glucose induces antitumor immunity and cytotoxicity in liver tumors in mice

(2020) Kyo Sasaki et al.   Cellular and Molecular Gastroenterology and Hepatology

Oncometabolites lactate and succinate drive pro-angiogenic macrophage response in tumors

(2020) Marjolein M.G. Kes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

The oncogenic and clinical implications of lactate induced immunosuppression in the tumour microenvironment

(2020) Conall Hayes et al.   CANCER LETTERS

Cellular Uptake of MCT1 Inhibitors AR-C155858 and AZD3965 and Their Effects on MCT-Mediated Transport of L-Lactate in Murine 4T1 Breast Tumor Cancer Cells

(2019) Xiaowen Guan et al.   AAPS Journal

Causes, consequences, and therapy of tumors acidosis

(2019) Smitha R. Pillai et al.   CANCER AND METASTASIS REVIEWS

Reactive Oxygen Species (ROS)-Based Nanomedicine

(2019) Bowen Yang et al.   CHEMICAL REVIEWS

Tumor microenvironment-driven non-cell-autonomous resistance to antineoplastic treatment

(2019) Yidi Qu et al.   Molecular Cancer

Reprogramming Tumor Immune Microenvironment (TIME) and Metabolism via Biomimetic Targeting Codelivery of Shikonin/JQ1

(2019) Hairui Wang et al.   NANO LETTERS

Nanoenabled Modulation of Acidic Tumor Microenvironment Reverses Anergy of Infiltrating T Cells and Potentiates Anti-PD-1 Therapy

(2019) Yu-Xue Zhang et al.   NANO LETTERS

Tumor Reoxygenation and Blood Perfusion Enhanced Photodynamic Therapy using Ultrathin Graphdiyne Oxide Nanosheets

(2019) Yucai Wang et al.   NANO LETTERS

Checkpoint blockade and nanosonosensitizer-augmented noninvasive sonodynamic therapy combination reduces tumour growth and metastases in mice

(2019) Wenwen Yue et al.   Nature Communications

Cancer nanomedicine for combination cancer immunotherapy

(2019) Jutaek Nam et al.   Nature Reviews Materials

Nanomedicines for Reactive Oxygen Species Mediated Approach: An Emerging Paradigm for Cancer Treatment

(2019) Seunglee Kwon et al.   ACCOUNTS OF CHEMICAL RESEARCH

Nanocatalytic Medicine

(2019) Bowen Yang et al.   ADVANCED MATERIALS

The Tumor Metabolic Microenvironment: Lessons from Lactate

(2019) Juan C. García-Cañaveras et al.   CANCER RESEARCH

Hollow Cu2Se Nanozymes for Tumor Photothermal-Catalytic Therapy

(2019) Xianwen Wang et al.   CHEMISTRY OF MATERIALS

Monocarboxylate transporters in cancer

(2019) Valéry L. Payen et al.   Molecular Metabolism

Near-Infrared II Phototherapy Induces Deep Tissue Immunogenic Cell Death and Potentiates Cancer Immunotherapy

(2019) Yinchu Ma et al.   ACS Nano

Nanocatalysts-augmented Fenton chemical reaction for nanocatalytic tumor therapy

(2019) Xiaoqin Qian et al.   BIOMATERIALS

The NIR inspired nano-CuSMn(II) composites for lactate and glycolysis attenuation

(2019) Xiu-Lin Fang et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Catalytically Selective Chemotherapy from Tumor‐Metabolic Generated Lactic Acid

(2019) Zhimin Tian et al.   Small

Amorphous Fe‐Based Nanoagents for Self‐Enhanced Chemodynamic Therapy by Re‐Establishing Tumor Acidosis

(2019) Xiaoyan Chen et al.   ADVANCED FUNCTIONAL MATERIALS

Intra/Extracellular Lactic Acid Exhaustion for Synergistic Metabolic Therapy and Immunotherapy of Tumors

(2019) Fan Gao et al.   ADVANCED MATERIALS

Tumor-intrinsic signaling pathways: key roles in the regulation of the immunosuppressive tumor microenvironment

(2019) Li Yang et al.   Journal of Hematology & Oncology

Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches

(2019) Karen G. de la Cruz-López et al.   Frontiers in Oncology

Engineering Multifunctional RNAi Nanomedicine To Concurrently Target Cancer Hallmarks for Combinatorial Therapy

(2018) Yanlan Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

50OA first-in-human first-in-class (FIC) trial of the monocarboxylate transporter 1 (MCT1) inhibitor AZD3965 in patients with advanced solid tumours

(2018) R Plummer et al.   ANNALS OF ONCOLOGY

Lactate biosensing: The emerging point-of-care and personal health monitoring

(2018) Fahmida Alam et al.   BIOSENSORS & BIOELECTRONICS

Catalytic chemistry of glucose oxidase in cancer diagnosis and treatment

(2018) Lian-Hua Fu et al.   CHEMICAL SOCIETY REVIEWS

Nanoparticle-triggered in situ catalytic chemical reactions for tumour-specific therapy

(2018) Han Lin et al.   CHEMICAL SOCIETY REVIEWS

An aptamer-Fe 3+ modified nanoparticle for lactate oxidation and tumor photodynamic therapy

(2018) Huan Yang et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects

(2018) Cyril Corbet et al.   Nature Communications

Interfering with Lactate-Fueled Respiration for Enhanced Photodynamic Tumor Therapy by a Porphyrinic MOF Nanoplatform

(2018) Zhao-Xia Chen et al.   ADVANCED FUNCTIONAL MATERIALS

Gas-Generating Nanoplatforms: Material Chemistry, Multifunctionality, and Gas Therapy

(2018) Luodan Yu et al.   ADVANCED MATERIALS

Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies

(2018) Maria Apicella et al.   Cell Metabolism

Targeting Tumor Microenvironment by Bioreduction-Activated Nanoparticles for Light-Triggered Virotherapy

(2018) S.-Ja Tseng et al.   ACS Nano

Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells

(2018) Don Benjamin et al.   Cell Reports

Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy

(2018) Yangbo Feng et al.   Cancer Medicine

Nanocatalytic Tumor Therapy by Biomimetic Dual Inorganic Nanozyme-Catalyzed Cascade Reaction

(2018) Shanshan Gao et al.   Advanced Science

Lactate: A Metabolic Driver in the Tumour Landscape

(2018) Luigi Ippolito et al.   TRENDS IN BIOCHEMICAL SCIENCES

Polymer Prodrug-Based Nanoreactors Activated by Tumor Acidity for Orchestrated Oxidation/Chemotherapy

(2017) Junjie Li et al.   NANO LETTERS

Glucose feeds the TCA cycle via circulating lactate

(2017) Sheng Hui et al.   NATURE

H2O2-responsive liposomal nanoprobe for photoacoustic inflammation imaging and tumor theranostics via in vivo chromogenic assay

(2017) Qian Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor-selective catalytic nanomedicine by nanocatalyst delivery

(2017) Minfeng Huo et al.   Nature Communications

The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters

(2016) B. Nancolas et al.   BIOCHEMICAL JOURNAL

Monocarboxylate transporters in the brain and in cancer

(2016) Jhudit Pérez-Escuredo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy

(2016) Zijian Zhou et al.   CHEMICAL SOCIETY REVIEWS

Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems

(2016) Mahdi Karimi et al.   CHEMICAL SOCIETY REVIEWS

Emerging Opportunities and Challenges in Cancer Immunotherapy

(2016) T. L. Whiteside et al.   CLINICAL CANCER RESEARCH

A novel small-molecule compound targeting CD147 inhibits the motility and invasion of hepatocellular carcinoma cells

(2016) Zhi-guang Fu et al.   Oncotarget

MCT1 Modulates Cancer Cell Pyruvate Export and Growth of Tumors that Co-express MCT1 and MCT4

(2016) Candice Sun Hong et al.   Cell Reports

Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy

(2015) Suzanne L. Topalian et al.   CANCER CELL

Monocarboxylate transport inhibition potentiates the cytotoxic effect of 5-fluorouracil in colorectal cancer cells

(2015) Ricardo Amorim et al.   CANCER LETTERS

Oxamate-mediated inhibition of lactate dehydrogenase induces protective autophagy in gastric cancer cells: Involvement of the Akt–mTOR signaling pathway

(2015) Zhi Zhao et al.   CANCER LETTERS

Amino Acid Transporters in Cancer and Their Relevance to "Glutamine Addiction": Novel Targets for the Design of a New Class of Anticancer Drugs

(2015) Y. D. Bhutia et al.   CANCER RESEARCH

Targeting mitochondria metabolism for cancer therapy

(2015) Samuel E Weinberg et al.   Nature Chemical Biology

Radiotherapy and Immunogenic Cell Death

(2015) Encouse B. Golden et al.   SEMINARS IN RADIATION ONCOLOGY

2-Deoxy-D-glucose targeting of glucose metabolism in cancer cells as a potential therapy

(2014) Dongsheng Zhang et al.   CANCER LETTERS

Cell Surface Lactate Receptor GPR81 Is Crucial for Cancer Cell Survival

(2014) C. L. Roland et al.   CANCER RESEARCH

Preclinical Pharmacokinetics, Tolerability, and Pharmacodynamics of Metuzumab, a Novel CD147 Human-Mouse Chimeric and Glycoengineered Antibody

(2014) Z. Zhang et al.   MOLECULAR CANCER THERAPEUTICS

Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth

(2014) Ubaldo E. Martinez-Outschoorn et al.   SEMINARS IN CANCER BIOLOGY

Downregulation of MCT1 inhibits tumor growth, metastasis and enhances chemotherapeutic efficacy in osteosarcoma through regulation of the NF-κB pathway

(2013) Zhiqiang Zhao et al.   CANCER LETTERS

Blocking Lactate Export by Inhibiting the Myc Target MCT1 Disables Glycolysis and Glutathione Synthesis

(2013) J. R. Doherty et al.   CANCER RESEARCH

Acidity Generated by the Tumor Microenvironment Drives Local Invasion

(2013) V. Estrella et al.   CANCER RESEARCH

Activity of the Monocarboxylate Transporter 1 Inhibitor AZD3965 in Small Cell Lung Cancer

(2013) R. Polanski et al.   CLINICAL CANCER RESEARCH

Targeting lactate metabolism for cancer therapeutics

(2013) Joanne R. Doherty et al.   JOURNAL OF CLINICAL INVESTIGATION

Dendritic Cell Reprogramming by Endogenously Produced Lactic Acid

(2013) A. Nasi et al.   JOURNAL OF IMMUNOLOGY

Metabolic targets for cancer therapy

(2013) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Role of Glutathione in Cancer Progression and Chemoresistance

(2013) Nicola Traverso et al.   Oxidative Medicine and Cellular Longevity

Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment

(2013) X Sui et al.   Cell Death & Disease

Tumor-derived lactate and myeloid-derived suppressor cells: Linking metabolism to cancer immunology

(2013) Zaheed Husain et al.   OncoImmunology

Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology

(2013) Gopinath Sutendra et al.   Frontiers in Oncology

A phase I dose-escalation trial of 2-deoxy-d-glucose alone or combined with docetaxel in patients with advanced solid tumors

(2012) Luis E. Raez et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Design, functionalization strategies and biomedical applications of targeted biodegradable/biocompatible polymer-based nanocarriers for drug delivery

(2012) Julien Nicolas et al.   CHEMICAL SOCIETY REVIEWS

Galloflavin, a new lactate dehydrogenase inhibitor, induces the death of human breast cancer cells with different glycolytic attitude by affecting distinct signaling pathways

(2012) F. Farabegoli et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Targeting glucose metabolism for cancer therapy: Figure 1.

(2012) Robert B. Hamanaka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Combination delivery of TGF-β inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy

(2012) Jason Park et al.   NATURE MATERIALS

Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner

(2012) Vikash P. Chauhan et al.   Nature Nanotechnology

Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF- B/IL-8 Pathway that Drives Tumor Angiogenesis

(2011) F. Vegran et al.   CANCER RESEARCH

Galloflavin (CAS 568-80-9): A Novel Inhibitor of Lactate Dehydrogenase

(2011) Marcella Manerba et al.   ChemMedChem

Lactate shuttles at a glance: from physiological paradigms to anti-cancer treatments

(2011) N. Draoui et al.   Disease Models & Mechanisms

Tumor lactic acidosis suppresses CTL function by inhibition of p38 and JNK/c-Jun activation

(2011) Anna N. Mendler et al.   INTERNATIONAL JOURNAL OF CANCER

Discovery ofN-Hydroxyindole-Based Inhibitors of Human Lactate Dehydrogenase Isoform A (LDH-A) as Starvation Agents against Cancer Cells

(2011) Carlotta Granchi et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Phase II Study of AT-101 (Gossypol) in Chemotherapy-Sensitive Recurrent Extensive-Stage Small Cell Lung Cancer

(2011) Maria Q. Baggstrom et al.   Journal of Thoracic Oncology

Hypoxia-activated prodrugs in cancer therapy: progress to the clinic

(2010) William A Denny   Future Oncology

One-to-one comparison of sunscreen efficacy, aesthetics and potential nanotoxicity

(2010) Amanda S. Barnard   Nature Nanotechnology

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

(2010) A. Le et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Open-Label, Multicenter, Phase I/II Study of Single-Agent AT-101 in Men with Castrate-Resistant Prostate Cancer

(2009) G. Liu et al.   CLINICAL CANCER RESEARCH

MYC-Induced Cancer Cell Energy Metabolism and Therapeutic Opportunities

(2009) C. V. Dang et al.   CLINICAL CANCER RESEARCH

HIF-1: upstream and downstream of cancer metabolism

(2009) Gregg L Semenza   CURRENT OPINION IN GENETICS & DEVELOPMENT

How can ab initio simulations address risks in nanotech?

(2009) Amanda S. Barnard   Nature Nanotechnology

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Roles of p53, Myc and HIF-1 in Regulating Glycolysis — the Seventh Hallmark of Cancer

(2008) S. J. Yeung et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA