Full-length IL-33 augments pulmonary fibrosis in an ST2- and Th2-independent, non-transcriptomic fashion

Emerging Functions of IL-33 in Homeostasis and Immunity

(2022) Gaelen K. Dwyer et al.   Annual Review of Immunology

The function of IL-33/ST2 signaling axis in treg cells activating fibrosis in IgG4-related disease

(2022) Yaxian Wu et al.   HUMAN IMMUNOLOGY

IL-33 Promotes ST2-Dependent Fibroblast Maturation via P38 and TGF-β in a Mouse Model of Epidural Fibrosis

(2022) Haoran Wang et al.   Tissue Engineering and Regenerative Medicine

Nuclear IL-33 restrains the early conversion of fibroblasts to an extracellular matrix-secreting phenotype

(2021) Francesca Gatti et al.   Scientific Reports

Nuclear IL‐33/SMAD signaling axis promotes cancer development in chronic inflammation

(2021) Jong Ho Park et al.   EMBO JOURNAL

Nuclear IL-33 Plays an Important Role in the Suppression of FLG, LOR, Keratin 1, and Keratin 10 by IL-4 and IL-13 in Human Keratinocytes

(2021) Xiuju Dai et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Regulator of Cell Cycle Protein (RGCC/RGC-32) Protects against Pulmonary Fibrosis

(2021) Irina G. Luzina et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The Nuclear Function of IL-33 in Desensitization to DNA Damaging Agent and Change of Glioma Nuclear Structure

(2021) Yu-Han Chung et al.   Frontiers in Cellular Neuroscience

Dysregulation of IL-33/ST2 signaling and myocardial periarteriolar fibrosis

(2019) Jessica C. Garbern et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Identification of the IL-33 protein segment that controls subcellular localization, extracellular secretion, and functional maturation

(2019) Irina G. Luzina et al.   CYTOKINE

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

ST2/IL-33 signaling in cardiac fibrosis

(2019) Elena Vianello et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

An ST2-dependent role of bone marrow-derived group 2 innate lymphoid cells in pulmonary fibrosis

(2018) Yuyue Zhao et al.   JOURNAL OF PATHOLOGY

Environmental allergens induce allergic inflammation through proteolytic maturation of IL-33

(2018) Corinne Cayrol et al.   NATURE IMMUNOLOGY

The IL-33 Receptor ST2 Regulates Pulmonary Inflammation and Fibrosis to Bleomycin

(2018) Manoussa Fanny et al.   Frontiers in Immunology

Chromatin regulates IL-33 release and extracellular cytokine activity

(2018) Jared Travers et al.   Nature Communications

Necroptosis directly induces the release of full-length biologically active IL-33 in vitro and in an inflammatory disease model

(2018) Inbar Shlomovitz et al.   FEBS Journal

IL-33/ST2 Axis in Organ Fibrosis

(2018) Ourania S. Kotsiou et al.   Frontiers in Immunology

Interleukin-33 signaling contributes to renal fibrosis following ischemia reperfusion

(2017) Hua Liang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Interleukin-33 (IL-33): A nuclear cytokine from the IL-1 family

(2017) Corinne Cayrol et al.   IMMUNOLOGICAL REVIEWS

The full-length interleukin-33 (FLIL33)–importin-5 interaction does not regulate nuclear localization of FLIL33 but controls its intracellular degradation

(2017) Andrew Clerman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Salmon provides fast and bias-aware quantification of transcript expression

(2017) Rob Patro et al.   NATURE METHODS

Elevated expression of NEU1 sialidase in idiopathic pulmonary fibrosis provokes pulmonary collagen deposition, lymphocytosis, and fibrosis

(2016) Irina G. Luzina et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

IL-33/ST2 pathway in a bleomycin-induced pulmonary fibrosis model

(2016) Jiao Xu et al.   Molecular Medicine Reports

Interleukin 33 is a guardian of barriers and a local alarmin

(2016) Nikolas T Martin et al.   NATURE IMMUNOLOGY

Combinatorial targeting of TSLP, IL-25, and IL-33 in type 2 cytokine–driven inflammation and fibrosis

(2016) Kevin M. Vannella et al.   Science Translational Medicine

Single high-dose irradiation aggravates eosinophil-mediated fibrosis through IL-33 secreted from impaired vessels in the skin compared to fractionated irradiation

(2015) Eun-Jung Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cigarette Smoke Silences Innate Lymphoid Cell Function and Facilitates an Exacerbated Type I Interleukin-33-Dependent Response to Infection

(2015) Jennifer Kearley et al.   IMMUNITY

The potential role of IL-33/ST2 signaling in fibrotic diseases

(2015) Qiaoyan Gao et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Bleomycin delivery by osmotic minipump: similarity to human scleroderma interstitial lung disease

(2014) Rebecca Lee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

IL-33 promotes ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in mice

(2014) Dong Li et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IFN-γ Directly Controls IL-33 Protein Level through a STAT1- and LMP2-dependent Mechanism

(2014) Pavel Kopach et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interleukin-33 Potentiates Bleomycin-Induced Lung Injury

(2013) Irina G. Luzina et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Interleukin-33-Dependent Innate Lymphoid Cells Mediate Hepatic Fibrosis

(2013) Tamar Mchedlidze et al.   IMMUNITY

Full-Length IL-33 Promotes Inflammation but not Th2 Response In Vivo in an ST2-Independent Fashion

(2012) I. G. Luzina et al.   JOURNAL OF IMMUNOLOGY

Endogenous IL-33 Is Highly Expressed in Mouse Epithelial Barrier Tissues, Lymphoid Organs, Brain, Embryos, and Inflamed Tissues: In Situ Analysis Using a Novel Il-33-LacZ Gene Trap Reporter Strain

(2012) M. Pichery et al.   JOURNAL OF IMMUNOLOGY

IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G

(2012) E. Lefrancais et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Progress Toward Improving Animal Models for Idiopathic Pulmonary Fibrosis

(2011) Amber L. Degryse et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Splice isoforms of human interleukin-4 are functionally active in mice in vivo

(2011) Irina G. Luzina et al.   IMMUNOLOGY

The Dual Function Cytokine IL-33 Interacts with the Transcription Factor NF- B To Dampen NF- B-Stimulated Gene Transcription

(2011) S. Ali et al.   JOURNAL OF IMMUNOLOGY

Alternatively spliced variants of interleukin-4 promote inflammation differentially

(2011) I. G. Luzina et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Regulation of pulmonary inflammation and fibrosis through expression of integrins αVβ3 and αVβ5 on pulmonary T lymphocytes

(2009) Irina G. Luzina et al.   ARTHRITIS AND RHEUMATISM

Caspase 3 inactivates biologically active full length interleukin-33 as a classical cytokine but does not prohibit nuclear translocation

(2009) Shafaqat Ali et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases

(2009) Alexander U. Lüthi et al.   IMMUNITY

Interleukin-33 Is Biologically Active Independently of Caspase-1 Cleavage

(2009) Dominique Talabot-Ayer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-33 Induces IL-13-Dependent Cutaneous Fibrosis

(2009) A. L. Rankin et al.   JOURNAL OF IMMUNOLOGY

The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1

(2009) C. Cayrol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of Th2 pulmonary inflammation in mice with bleomycin-induced pulmonary fibrosis

(2008) Hirokuni HIRATA et al.   RESPIROLOGY