Discovery of a potent allosteric activator of DGKQ that ameliorates obesity-induced insulin resistance via the sn-1,2-DAG-PKCε signaling axis
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Discovery of a potent allosteric activator of DGKQ that ameliorates obesity-induced insulin resistance via the sn-1,2-DAG-PKCε signaling axis
Authors
Keywords
-
Journal
Cell Metabolism
Volume 35, Issue 1, Pages 101-117.e11
Publisher
Elsevier BV
Online
2022-12-15
DOI
10.1016/j.cmet.2022.11.012
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity
- (2021) Suzhen Chen et al. Cell Metabolism
- Mechanisms and disease consequences of nonalcoholic fatty liver disease
- (2021) Rohit Loomba et al. CELL
- Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway
- (2020) Zu-Guo Zheng et al. Autophagy
- A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance
- (2020) Kun Lyu et al. Cell Metabolism
- Evaluation of insulin sensitivity by hyperinsulinemic-euglycemic clamps using stable isotope-labeled glucose
- (2018) Yuanyuan Zhang et al. Cell Discovery
- Protein Kinase C Epsilon Deletion in Adipose Tissue, but Not in Liver, Improves Glucose Tolerance
- (2018) Amanda E. Brandon et al. Cell Metabolism
- Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans
- (2017) Kasper W. ter Horst et al. Cell Reports
- Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance
- (2016) Max C. Petersen et al. JOURNAL OF CLINICAL INVESTIGATION
- Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease
- (2016) Panu K. Luukkonen et al. JOURNAL OF HEPATOLOGY
- DCP-LA Activates Cytosolic PKCε by Interacting with the Phosphatidylserine Binding/Associating Sites Arg50 and Ile89 in the C2-Like Domain
- (2015) Takeshi Kanno et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats
- (2015) R. J. Perry et al. SCIENCE
- The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes
- (2014) Rachel J. Perry et al. NATURE
- Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling
- (2013) Y. Zhang et al. DIABETES
- Evidence for the role of AMPK in regulating PGC-1 alpha expression and mitochondrial proteins in mouse epididymal adipose tissue
- (2013) Zhongxiao Wan et al. Obesity
- Evaluations of the Selectivities of the Diacylglycerol Kinase Inhibitors R59022 and R59949 Among Diacylglycerol Kinase Isozymes Using a New Non-Radioactive Assay Method
- (2013) Mayu Sato et al. PHARMACOLOGY
- Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay
- (2013) D. M. Molina et al. SCIENCE
- Diacylglycerol Activation of Protein Kinase Cε and Hepatic Insulin Resistance
- (2012) François R. Jornayvaz et al. Cell Metabolism
- Intrahepatic Diacylglycerol Content Is Associated With Hepatic Insulin Resistance in Obese Subjects
- (2012) Faidon Magkos et al. GASTROENTEROLOGY
- Regulation and roles of neuronal diacylglycerol kinases: a lipid perspective
- (2011) Becky Tu-Sekine et al. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease
- (2011) N. Kumashiro et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Target identification using drug affinity responsive target stability (DARTS)
- (2009) B. Lomenick et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Diacylglycerol kinases: at the hub of cell signalling
- (2007) Isabel Mérida et al. BIOCHEMICAL JOURNAL
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now