Discovery of a potent allosteric activator of DGKQ that ameliorates obesity-induced insulin resistance via the sn-1,2-DAG-PKCε signaling axis

The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity

(2021) Suzhen Chen et al.   Cell Metabolism

Mechanisms and disease consequences of nonalcoholic fatty liver disease

(2021) Rohit Loomba et al.   CELL

Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway

(2020) Zu-Guo Zheng et al.   Autophagy

A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance

(2020) Kun Lyu et al.   Cell Metabolism

Evaluation of insulin sensitivity by hyperinsulinemic-euglycemic clamps using stable isotope-labeled glucose

(2018) Yuanyuan Zhang et al.   Cell Discovery

Protein Kinase C Epsilon Deletion in Adipose Tissue, but Not in Liver, Improves Glucose Tolerance

(2018) Amanda E. Brandon et al.   Cell Metabolism

Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans

(2017) Kasper W. ter Horst et al.   Cell Reports

Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance

(2016) Max C. Petersen et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease

(2016) Panu K. Luukkonen et al.   JOURNAL OF HEPATOLOGY

DCP-LA Activates Cytosolic PKCε by Interacting with the Phosphatidylserine Binding/Associating Sites Arg50 and Ile89 in the C2-Like Domain

(2015) Takeshi Kanno et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats

(2015) R. J. Perry et al.   SCIENCE

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

(2014) Rachel J. Perry et al.   NATURE

Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling

(2013) Y. Zhang et al.   DIABETES

Evidence for the role of AMPK in regulating PGC-1 alpha expression and mitochondrial proteins in mouse epididymal adipose tissue

(2013) Zhongxiao Wan et al.   Obesity

Evaluations of the Selectivities of the Diacylglycerol Kinase Inhibitors R59022 and R59949 Among Diacylglycerol Kinase Isozymes Using a New Non-Radioactive Assay Method

(2013) Mayu Sato et al.   PHARMACOLOGY

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

(2013) D. M. Molina et al.   SCIENCE

Diacylglycerol Activation of Protein Kinase Cε and Hepatic Insulin Resistance

(2012) François R. Jornayvaz et al.   Cell Metabolism

Intrahepatic Diacylglycerol Content Is Associated With Hepatic Insulin Resistance in Obese Subjects

(2012) Faidon Magkos et al.   GASTROENTEROLOGY

Regulation and roles of neuronal diacylglycerol kinases: a lipid perspective

(2011) Becky Tu-Sekine et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

(2011) N. Kumashiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Target identification using drug affinity responsive target stability (DARTS)

(2009) B. Lomenick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diacylglycerol kinases: at the hub of cell signalling

(2007) Isabel Mérida et al.   BIOCHEMICAL JOURNAL