SPY1 inhibits neuronal ferroptosis in amyotrophic lateral sclerosis by reducing lipid peroxidation through regulation of GCH1 and TFR1

Ferroptosis: mechanisms, biology and role in disease

(2021) Xuejun Jiang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PAK4 suppresses motor neuron degeneration in hSOD1 G93A ‐linked amyotrophic lateral sclerosis cell and rat models

(2021) Chaohua Cong et al.   CELL PROLIFERATION

Involvement of ferroptosis in human motor neuron cell death

(2021) Tsuyoshi Matsuo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular mechanisms of cell death in neurological diseases

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Overexpression of ferroptosis defense enzyme Gpx4 retards motor neuron disease of SOD1G93A mice

(2021) Liuji Chen et al.   Scientific Reports

Ferroptosis mediates selective motor neuron death in amyotrophic lateral sclerosis

(2021) Taide Wang et al.   CELL DEATH AND DIFFERENTIATION

MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling

(2020) Divya Venkatesh et al.   GENES & DEVELOPMENT

GDF15 knockdown promotes erastin-induced ferroptosis by decreasing SLC7A11 expression

(2020) Liang Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-Lipoxygenase-2 in biosynthesis of resolvin D5

(2020) Steven C Perry et al.   JOURNAL OF LIPID RESEARCH

Genetic inactivation of RIP1 kinase does not ameliorate disease in a mouse model of ALS

(2020) Sara Dominguez et al.   CELL DEATH AND DIFFERENTIATION

ALS Genetics: Gains, Losses, and Implications for Future Therapies

(2020) Garam Kim et al.   NEURON

The Relevancy of Data Regarding the Metabolism of Iron to Our Understanding of Deregulated Mechanisms in ALS; Hypotheses and Pitfalls

(2019) Camille Petillon et al.   Frontiers in Neuroscience

Kinome screen of ferroptosis reveals a novel role of ATM in regulating iron metabolism

(2019) Po-Han Chen et al.   CELL DEATH AND DIFFERENTIATION

Cu II (atsm) inhibits ferroptosis: implications for treatment of neurodegenerative disease

(2019) Authors Adam Southon et al.   BRITISH JOURNAL OF PHARMACOLOGY

Necroptosis is dispensable for motor neuron degeneration in a mouse model of ALS

(2019) Taide Wang et al.   CELL DEATH AND DIFFERENTIATION

Edaravone, a free radical scavenger, protects against ferroptotic cell death in vitro

(2019) Takujiro Homma et al.   EXPERIMENTAL CELL RESEARCH

Wild-type p53-induced phosphatase 1 down-regulation promotes apoptosis by activating the DNA damage-response pathway in amyotrophic lateral sclerosis

(2019) Yue-Qing Yang et al.   NEUROBIOLOGY OF DISEASE

GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling

(2019) Vanessa A. N. Kraft et al.   ACS Central Science

Spy1, a unique cell cycle regulator, alters viability in ALS motor neurons and cell lines in response to mutant SOD1-induced DNA damage

(2018) Xu-Dong Wang et al.   DNA REPAIR

Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin

(2018) Eileen McNeill et al.   Nature Communications

NSC-34 motor neuron-like cells are sensitized to ferroptosis upon differentiation

(2018) Alejandra M. Martinez et al.   FEBS Open Bio

An integrated bioinformatics platform for investigating the human E3 ubiquitin ligase-substrate interaction network

(2017) Yang Li et al.   Nature Communications

Amyotrophic lateral sclerosis

(2017) Orla Hardiman et al.   Nature Reviews Disease Primers

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS

(2016) Yasushi Ito et al.   SCIENCE

Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis

(2015) Liuji Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

System xC− is a mediator of microglial function and its deletion slows symptoms in amyotrophic lateral sclerosis mice

(2014) Pinar Mesci et al.   BRAIN

The Cyclin-like Protein Spy1 Regulates Growth and Division Characteristics of the CD133+ Population in Human Glioma

(2014) Dorota Lubanska et al.   CANCER CELL

Necroptosis Drives Motor Neuron Death in Models of Both Sporadic and Familial ALS

(2014) Diane B. Re et al.   NEURON

Differentiated NSC-34 motoneuron-like cells as experimental model for cholinergic neurodegeneration

(2013) Oliver Maier et al.   NEUROCHEMISTRY INTERNATIONAL

Review: Iron metabolism and the role of iron in neurodegenerative disorders

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Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Dysregulation of iron protein expression in the G93A model of amyotrophic lateral sclerosis

(2012) M. Hadzhieva et al.   NEUROSCIENCE

The atypical CDK activator Spy1 regulates the intrinsic DNA damage response and is dependent upon p53 to inhibit apoptosis

(2011) Christopher W. McAndrew et al.   CELL CYCLE

Prevention of Motor Neuron Degeneration by Novel Iron Chelators in SOD1G93A Transgenic Mice of Amyotrophic Lateral Sclerosis

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Cell cycle regulation of the mammalian CDK activator RINGO/Speedy A

(2009) Ana Dinarina et al.   FEBS LETTERS

Dysregulation of Iron Homeostasis in the CNS Contributes to Disease Progression in a Mouse Model of Amyotrophic Lateral Sclerosis

(2009) S. Y. Jeong et al.   JOURNAL OF NEUROSCIENCE

The Spy1/RINGO Family Represents a Novel Mechanism Regulating Mammary Growth and Tumorigenesis

(2008) A. Golipour et al.   CANCER RESEARCH

The Cyclin-dependent Kinase Activator, Spy1A, Is Targeted for Degradation by the Ubiquitin Ligase NEDD4

(2008) Mohammad Al Sorkhy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH

Specificity proteins Sp1 and Sp3 interact with the rat GTP Cyclohydrolase I proximal promoter to regulate transcription

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