PAK4 suppresses motor neuron degeneration in hSOD1 G93A ‐linked amyotrophic lateral sclerosis cell and rat models

TDP-43 dysfunction restricts dendritic complexity by inhibiting CREB activation and altering gene expression

(2020) Josiah J. Herzog et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The effects of diet and sex in amyotrophic lateral sclerosis

(2020) J.A. Pape et al.   REVUE NEUROLOGIQUE

Neuroprotection by urate on the mutant hSOD1-related cellular and Drosophila models of amyotrophic lateral sclerosis: Implication for GSH synthesis via activating Akt/GSK3β/Nrf2/GCLC pathways

(2019) Chunting Zhang et al.   BRAIN RESEARCH BULLETIN

C9ORF72-ALS/FTD-associated poly(GR) binds Atp5a1 and compromises mitochondrial function in vivo

(2019) So Yoen Choi et al.   NATURE NEUROSCIENCE

Loss of endosomal recycling factor RAB11 coupled with complex regulation of MAPK/ERK/AKT signaling in postmortem spinal cord specimens of sporadic amyotrophic lateral sclerosis patients

(2019) Joy Mitra et al.   Molecular Brain

LanCL1 promotes motor neuron survival and extends the lifespan of amyotrophic lateral sclerosis mice

(2019) Honglin Tan et al.   CELL DEATH AND DIFFERENTIATION

Lithium facilitates removal of misfolded proteins and attenuated faulty interaction between mutant SOD1 and p-CREB (Ser133) through enhanced autophagy in mutant hSOD1G93A transfected neuronal cell lines

(2019) Xiang Yin et al.   MOLECULAR BIOLOGY REPORTS

PAK4, a target of miR-9-5p, promotes cell proliferation and inhibits apoptosis in colorectal cancer

(2019) Meihua Wang et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

PAK4 suppresses RELB to prevent senescence-like growth arrest in breast cancer

(2019) Tânia D. F. Costa et al.   Nature Communications

Dipeptide IF prevents the effects of hypertension‐induced Alzheimer's disease on long‐term memory in the cortex of spontaneously hypertensive rats

(2019) Yung‐Ming Chang et al.   ENVIRONMENTAL TOXICOLOGY

Wild-type p53-induced phosphatase 1 down-regulation promotes apoptosis by activating the DNA damage-response pathway in amyotrophic lateral sclerosis

(2019) Yue-Qing Yang et al.   NEUROBIOLOGY OF DISEASE

MiR-199a/b-3p inhibits gastric cancer cell proliferation via down-regulating PAK4/MEK/ERK signaling pathway

(2018) Bin Zeng et al.   BMC CANCER

PAK1 regulates ATXN1 levels providing an opportunity to modify its toxicity in spinocerebellar ataxia type 1

(2018) Vitaliy V Bondar et al.   HUMAN MOLECULAR GENETICS

Small RNA Sequencing of Sporadic Amyotrophic Lateral Sclerosis Cerebrospinal Fluid Reveals Differentially Expressed miRNAs Related to Neural and Glial Activity

(2018) Rachel Waller et al.   Frontiers in Neuroscience

Per-Arnt-Sim Kinase (PASK) Deficiency Increases Cellular Respiration on a Standard Diet and Decreases Liver Triglyceride Accumulation on a Western High-Fat High-Sugar Diet

(2018) Jenny Pape et al.   Nutrients

Amyotrophic lateral sclerosis

(2017) Orla Hardiman et al.   Nature Reviews Disease Primers

A look into the future of ALS research

(2016) Pascaline Clerc et al.   DRUG DISCOVERY TODAY

ALS: A bucket of genes, environment, metabolism and unknown ingredients

(2016) Mónica Zufiría et al.   PROGRESS IN NEUROBIOLOGY

Nigral dopaminergic PAK4 prevents neurodegeneration in rat models of Parkinsons disease

(2016) S.-Y. Won et al.   Science Translational Medicine

miRNA Deregulation in Cancer Cells and the Tumor Microenvironment

(2016) R. Rupaimoole et al.   Cancer Discovery

p21-Activated Kinase 4 Critically Regulates Melanogenesis via Activation of the CREB/MITF and β-Catenin/MITF Pathways

(2015) Cheong-Yong Yun et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain

(2015) Laura Civiero et al.   JOURNAL OF NEUROCHEMISTRY

Downregulated AEG-1 together with inhibited PI3K/Akt pathway is associated with reduced viability of motor neurons in an ALS model

(2015) Xiang Yin et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Neuroprotective Effect of Human Adipose Stem Cell-Derived Extract in Amyotrophic Lateral Sclerosis

(2015) Gye Sun Jeon et al.   NEUROCHEMICAL RESEARCH

p-21 activated kinase 4 promotes proliferation and survival of pancreatic cancer cells through AKT- and ERK-dependent activation of NF-κB pathway

(2015) Nikhil Tyagi et al.   Oncotarget

Distinct pathways leading to TDP-43-induced cellular dysfunctions

(2014) Makiko Yamashita et al.   HUMAN MOLECULAR GENETICS

MicroRNA-433 inhibits cell proliferation in hepatocellular carcinoma by targeting p21 activated kinase (PAK4)

(2014) Jing Xue et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

 -Amyloid Disrupts Activity-Dependent Gene Transcription Required for Memory through the CREB Coactivator CRTC1

(2013) J. Espana et al.   JOURNAL OF NEUROSCIENCE

PF-3758309, p21-activated kinase 4 inhibitor, suppresses migration and invasion of A549 human lung cancer cells via regulation of CREB, NF-κB, and β-catenin signalings

(2013) Byung Jun Ryu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

RAS–MAPK–MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1

(2013) Jeehye Park et al.   NATURE

State of play in amyotrophic lateral sclerosis genetics

(2013) Alan E Renton et al.   NATURE NEUROSCIENCE

The changing scene of amyotrophic lateral sclerosis

(2013) Wim Robberecht et al.   NATURE REVIEWS NEUROSCIENCE

Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486

(2013) B. M. Dolan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CREB regulates spine density of lateral amygdala neurons: implications for memory allocation

(2013) Derya Sargin et al.   Frontiers in Behavioral Neuroscience

Amyotrophic lateral sclerosis and cancer: A register-based study in Sweden

(2013) Fang Fang et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Transducer of regulated CREB-binding proteins (TORCs) transcription and function is impaired in Huntington's disease

(2012) Rajnish Kumar Chaturvedi et al.   HUMAN MOLECULAR GENETICS

p21-Activated kinase 4 promotes prostate cancer progression through CREB

(2012) M-H Park et al.   ONCOGENE

Phosphatase and tensin homologue/protein kinase B pathway linked to motor neuron survival in human superoxide dismutase 1-related amyotrophic lateral sclerosis

(2011) Janine Kirby et al.   BRAIN

PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease

(2011) Joo-Ho Shin et al.   CELL

Population based epidemiology of amyotrophic lateral sclerosis using capture-recapture methodology

(2011) M. H. B. Huisman et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway

(2011) Hyunkyung Jeong et al.   NATURE MEDICINE

Clinical genetics of amyotrophic lateral sclerosis: what do we really know?

(2011) Peter M. Andersen et al.   Nature Reviews Neurology

The sex ratio in amyotrophic lateral sclerosis: A population based study

(2010) Zita R. Manjaly et al.   Amyotrophic Lateral Sclerosis

Current hypotheses for the underlying biology of amyotrophic lateral sclerosis

(2010) Jeffrey D. Rothstein   ANNALS OF NEUROLOGY

Rate of familial amyotrophic lateral sclerosis: a systematic review and meta-analysis

(2010) S. Byrne et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

TORC1 Regulates Activity-Dependent CREB-Target Gene Transcription and Dendritic Growth of Developing Cortical Neurons

(2009) S. Li et al.   JOURNAL OF NEUROSCIENCE

Effect of rosmarinic acid in motor dysfunction and life span in a mouse model of familial amyotrophic lateral sclerosis

(2009) Yosuke Shimojo et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Enhanced CREB-dependent gene expression increases the excitability of neurons in the basal amygdala and primes the consolidation of contextual and cued fear memory

(2009) J. Viosca et al.   LEARNING & MEMORY

CREB regulates excitability and the allocation of memory to subsets of neurons in the amygdala

(2009) Yu Zhou et al.   NATURE NEUROSCIENCE

Epidemiology of ALS in Italy: A 10-year prospective population-based study

(2009) A. Chio et al.   NEUROLOGY

A tale of two Paks

(2008) Luis E. Arias-Romero et al.   BIOLOGY OF THE CELL

Targeted disruption of the Pak5 and Pak6 genes in mice leads to deficits in learning and locomotion

(2008) Tanya Nekrasova et al.   DEVELOPMENTAL BIOLOGY

Combined lithium and valproate treatment delays disease onset, reduces neurological deficits and prolongs survival in an amyotrophic lateral sclerosis mouse model

(2008) H.-L. Feng et al.   NEUROSCIENCE

TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

(2008) J. Sreedharan et al.   SCIENCE