SARS-CoV-2 replication in airway epithelia requires motile cilia and microvillar reprogramming

Structures of the Omicron Spike trimer with ACE2 and an anti-Omicron antibody

(2022) Wanchao Yin et al.   SCIENCE

SARS-CoV-2 infects cells following viral entry via clathrin-mediated endocytosis

(2021) Armin Bayati et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SARS-CoV-2 D614G spike mutation increases entry efficiency with enhanced ACE2-binding affinity

(2021) Seiya Ozono et al.   Nature Communications

Single cell resolution of SARS-CoV-2 tropism, antiviral responses, and susceptibility to therapies in primary human airway epithelium

(2021) Jessica K. Fiege et al.   PLoS Pathogens

SARS-CoV-2 infections in people with PCD: neither frequent, nor particularly severe

(2021) Eva S.L. Pedersen et al.   EUROPEAN RESPIRATORY JOURNAL

Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes

(2021) Neal G. Ravindra et al.   PLOS BIOLOGY

In vitro data suggest that Indian delta variant B.1.617 of SARS‐CoV‐2 escapes neutralization by both receptor affinity and immune evasion

(2021) Gilles Augusto et al.   ALLERGY

In vivo monoclonal antibody efficacy against SARS-CoV-2 variant strains

(2021) Rita E. Chen et al.   NATURE

Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb

(2021) Mona Khan et al.   CELL

SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients

(2020) Lirong Zou et al.   NEW ENGLAND JOURNAL OF MEDICINE

SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract

(2020) Yixuan J. Hou et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

First contact: The role of respiratory cilia in host-pathogen interactions in the airways

(2020) Li Eon Kuek et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The Global Phosphorylation Landscape of SARS-CoV-2 Infection

(2020) Mehdi Bouhaddou et al.   CELL

Quantum Dot-Conjugated SARS-CoV-2 Spike Pseudo-Virions Enable Tracking of Angiotensin Converting Enzyme 2 Binding and Endocytosis

(2020) Kirill Gorshkov et al.   ACS Nano

Non-muscle myosin-2 contractility-dependent actin turnover limits the length of epithelial microvilli

(2020) Colbie R. Chinowsky et al.   MOLECULAR BIOLOGY OF THE CELL

SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function

(2020) Emma S. Winkler et al.   NATURE IMMUNOLOGY

Ultrastructural analysis of SARS-CoV-2 interactions with the host cell via high resolution scanning electron microscopy

(2020) Lucio Ayres Caldas et al.   Scientific Reports

The central role of the nasal microenvironment in the transmission, modulation, and clinical progression of SARS-CoV-2 infection

(2020) Oreste Gallo et al.   Mucosal Immunology

The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins

(2019) Stacy A. Malaker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multivalent Recognition at Fluid Surfaces: The Interplay of Receptor Clustering and Superselectivity

(2019) Galina V. Dubacheva et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Non-canonical Notch Signaling Regulates Actin Remodeling in Cell Migration by Activating PI3K/AKT/Cdc42 Pathway

(2019) Lei Liu et al.   Frontiers in Pharmacology

Characterization of the ERG-regulated Kinome in Prostate Cancer Identifies TNIK as a Potential Therapeutic Target

(2019) Rachel S Lee et al.   NEOPLASIA

CX3CR1 as a respiratory syncytial virus receptor in pediatric human lung

(2019) Christopher S. Anderson et al.   PEDIATRIC RESEARCH

Ciliary Localization of the Intraflagellar Transport Protein IFT88 Is Disrupted in Cystic Fibrosis

(2019) Elizabeth M. Stevens et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

A revised airway epithelial hierarchy includes CFTR-expressing ionocytes

(2018) Daniel T. Montoro et al.   NATURE

Activating Mutations in PAK1, Encoding p21-Activated Kinase 1, Cause a Neurodevelopmental Disorder

(2018) Frederike L. Harms et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Regulation of actin-based apical structures on epithelial cells

(2018) Thaher Pelaseyed et al.   JOURNAL OF CELL SCIENCE

Ciliary protein trafficking mediated by IFT and BBSome complexes with the aid of kinesin-2 and dynein-2 motors

(2017) Kazuhisa Nakayama et al.   JOURNAL OF BIOCHEMISTRY

In Vitro Model of Fully Differentiated Human Nasal Epithelial Cells Infected With Rhinovirus Reveals Epithelium-Initiated Immune Responses

(2017) Kai Sen Tan et al.   JOURNAL OF INFECTIOUS DISEASES

The cell surface mucin MUC1 limits the severity of influenza A virus infection

(2017) J L McAuley et al.   Mucosal Immunology

Primary Ciliary Dyskinesia: An Update on Clinical Aspects, Genetics, Diagnosis, and Future Treatment Strategies

(2017) Virginia Mirra et al.   Frontiers in Pediatrics

Comprehensive proteome analysis of brush border membrane fraction of ileum of ezrin knockdown mice

(2016) Saori YOSHIDA et al.   BIOMEDICAL RESEARCH-TOKYO

Characterization of isoform expression and subcellular distribution of MYPT1 in intestinal epithelial cells

(2016) Juan-Min Zha et al.   GENE

Ccdc11 is a novel centriolar satellite protein essential for ciliogenesis and establishment of left–right asymmetry

(2016) Erica Silva et al.   MOLECULAR BIOLOGY OF THE CELL

An atlas of human kinase regulation

(2016) David Ochoa et al.   Molecular Systems Biology

Plasticity of the brush border — the yin and yang of intestinal homeostasis

(2016) Delphine Delacour et al.   Nature Reviews Gastroenterology & Hepatology

Cilia and Mucociliary Clearance

(2016) Ximena M. Bustamante-Marin et al.   Cold Spring Harbor Perspectives in Biology

Ezrin: a regulator of actin microfilaments in cell junctions of the rat testis

(2015) CYan Cheng et al.   ASIAN JOURNAL OF ANDROLOGY

Annexin A2–dependent actin bundling promotes secretory granule docking to the plasma membrane and exocytosis

(2015) Marion Gabel et al.   JOURNAL OF CELL BIOLOGY

PCTK1 Regulates Integrin-Dependent Spindle Orientation via Protein Kinase A Regulatory Subunit KAP0 and Myosin X

(2015) Sayaka Iwano et al.   MOLECULAR AND CELLULAR BIOLOGY

The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking

(2015) Leila Belle et al.   Science Signaling

Respiratory Syncytial Virus Uses CX3CR1 as a Receptor on Primary Human Airway Epithelial Cultures

(2015) Sara M. Johnson et al.   PLoS Pathogens

The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking

(2015) Leila Belle et al.   Science Signaling

CX3CR1 Is Expressed in Differentiated Human Ciliated Airway Cells and Co-Localizes with Respiratory Syncytial Virus on Cilia in a G Protein-Dependent Manner

(2015) Kwang-Il Jeong et al.   PLoS One

Shaping the intestinal brush border

(2014) Scott W. Crawley et al.   JOURNAL OF CELL BIOLOGY

PhosphoSitePlus, 2014: mutations, PTMs and recalibrations

(2014) Peter V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

CDC42 switches IRSp53 from inhibition of actin growth to elongation by clustering of VASP

(2013) Andrea Disanza et al.   EMBO JOURNAL

In Vivo SILAC-Based Proteomics Reveals Phosphoproteome Changes during Mouse Skin Carcinogenesis

(2013) Sara Zanivan et al.   Cell Reports

Molecular organization of the mucins and glycocalyx underlying mucus transport over mucosal surfaces of the airways

(2012) M Kesimer et al.   Mucosal Immunology

Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein

(2012) Ari J. Firestone et al.   NATURE

Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression

(2012) J. M. Drake et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Periciliary Brush Promotes the Lung Health by Separating the Mucus Layer from Airway Epithelia

(2012) B. Button et al.   SCIENCE

LCH-7749944, a novel and potent p21-activated kinase 4 inhibitor, suppresses proliferation and invasion in human gastric cancer cells

(2011) Jian Zhang et al.   CANCER LETTERS

mDia1 and WAVE2 Proteins Interact Directly with IRSp53 in Filopodia and Are Involved in Filopodium Formation

(2011) Wah Ing Goh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Infection of Differentiated Porcine Airway Epithelial Cells by Influenza Virus: Differential Susceptibility to Infection by Porcine and Avian Viruses

(2011) Darsaniya Punyadarsaniya et al.   PLoS One

Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity

(2010) Mutsuki Amano et al.   Cytoskeleton

TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia

(2010) S. Mukhopadhyay et al.   GENES & DEVELOPMENT

Cystic Fibrosis Transmembrane Conductance Regulator Interacts with Multiple Immunoglobulin Domains of Filamin A

(2010) Martin P. Playford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of IRSp53-Dependent Filopodial Dynamics by Antagonism between 14-3-3 Binding and SH3-Mediated Localization

(2009) J. M. Robens et al.   MOLECULAR AND CELLULAR BIOLOGY

Myosin phosphatase target subunit: Many roles in cell function

(2008) Fumio Matsumura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Loss of Bardet-Biedl syndrome proteins alters the morphology and function of motile cilia in airway epithelia

(2008) A. S. Shah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA